Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and size
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/211565 |
Resumo: | Solubility of pharmaceutical drugs in organic solvents is one of the important parameters to understand the equilibrium concentration of solute-solvent, which helps optimize and design crystallization conditions to obtain the desired product crystals. In the present study, Chlorzoxazone (CHZ) is used as a model pharmaceutical compound to investigate the equilibrium solubility, the influence of solvent and the operating conditions on the shape, and the size distribution. The solubility of CHZ is determined in organic solvents like Isopropanol, Ethanol, and 2-Ethoxyethylacetate, Ethylacetate and Ethyllactate using shake flask method from -5ºC to 60ºC. The solubility of CHZ in these solvents shows an increasing trend as the temperature increases in the following order: ethyllactate + water (0.5+0.5) < ethylacetate < isopropanol < ethanol < 2-ethoxyethylacetate < ethyllactate + water (0.75+0.25). The solvents, isopropanol, ethanol, and ethyl lactate, produce needle-shaped crystals, while 2-ethoxyethylacetate and ethyl acetate tend to produce plate shaped crystals. CHZ crystals obtained from 2-ethoxyethylacetate tend to have plate shaped crystals with a lower aspect ratio and are selected for batch cooling crystallization experiments performed at different cooling rates, and agitation. It is found that the agitation at 300 rpm and the cooling rate 0.2ºC/min produce more uniform crystal size distribution. |
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Brazilian Journal of Pharmaceutical Sciences |
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Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and sizeChlorzoxazoneSolubilityCooling crystallizationSolvent choiceCrystal shapeSize distributionSolubility of pharmaceutical drugs in organic solvents is one of the important parameters to understand the equilibrium concentration of solute-solvent, which helps optimize and design crystallization conditions to obtain the desired product crystals. In the present study, Chlorzoxazone (CHZ) is used as a model pharmaceutical compound to investigate the equilibrium solubility, the influence of solvent and the operating conditions on the shape, and the size distribution. The solubility of CHZ is determined in organic solvents like Isopropanol, Ethanol, and 2-Ethoxyethylacetate, Ethylacetate and Ethyllactate using shake flask method from -5ºC to 60ºC. The solubility of CHZ in these solvents shows an increasing trend as the temperature increases in the following order: ethyllactate + water (0.5+0.5) < ethylacetate < isopropanol < ethanol < 2-ethoxyethylacetate < ethyllactate + water (0.75+0.25). The solvents, isopropanol, ethanol, and ethyl lactate, produce needle-shaped crystals, while 2-ethoxyethylacetate and ethyl acetate tend to produce plate shaped crystals. CHZ crystals obtained from 2-ethoxyethylacetate tend to have plate shaped crystals with a lower aspect ratio and are selected for batch cooling crystallization experiments performed at different cooling rates, and agitation. It is found that the agitation at 300 rpm and the cooling rate 0.2ºC/min produce more uniform crystal size distribution.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-04-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://www.revistas.usp.br/bjps/article/view/21156510.1590/s2175-97902023e20918Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e20918Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e20918Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e209182175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/211565/194569https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessDhayananth NatarajanKalaichelvi PonnusamyRadhakrishnan Thota KarunakaranKarthika Shanmugam2024-04-10T13:43:09Zoai:revistas.usp.br:article/211565Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2024-04-10T13:43:09Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and size |
title |
Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and size |
spellingShingle |
Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and size Dhayananth Natarajan Chlorzoxazone Solubility Cooling crystallization Solvent choice Crystal shape Size distribution |
title_short |
Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and size |
title_full |
Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and size |
title_fullStr |
Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and size |
title_full_unstemmed |
Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and size |
title_sort |
Influence of solvent choice and operating conditions on Chlorzoxazone crystal shape and size |
author |
Dhayananth Natarajan |
author_facet |
Dhayananth Natarajan Kalaichelvi Ponnusamy Radhakrishnan Thota Karunakaran Karthika Shanmugam |
author_role |
author |
author2 |
Kalaichelvi Ponnusamy Radhakrishnan Thota Karunakaran Karthika Shanmugam |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Dhayananth Natarajan Kalaichelvi Ponnusamy Radhakrishnan Thota Karunakaran Karthika Shanmugam |
dc.subject.por.fl_str_mv |
Chlorzoxazone Solubility Cooling crystallization Solvent choice Crystal shape Size distribution |
topic |
Chlorzoxazone Solubility Cooling crystallization Solvent choice Crystal shape Size distribution |
description |
Solubility of pharmaceutical drugs in organic solvents is one of the important parameters to understand the equilibrium concentration of solute-solvent, which helps optimize and design crystallization conditions to obtain the desired product crystals. In the present study, Chlorzoxazone (CHZ) is used as a model pharmaceutical compound to investigate the equilibrium solubility, the influence of solvent and the operating conditions on the shape, and the size distribution. The solubility of CHZ is determined in organic solvents like Isopropanol, Ethanol, and 2-Ethoxyethylacetate, Ethylacetate and Ethyllactate using shake flask method from -5ºC to 60ºC. The solubility of CHZ in these solvents shows an increasing trend as the temperature increases in the following order: ethyllactate + water (0.5+0.5) < ethylacetate < isopropanol < ethanol < 2-ethoxyethylacetate < ethyllactate + water (0.75+0.25). The solvents, isopropanol, ethanol, and ethyl lactate, produce needle-shaped crystals, while 2-ethoxyethylacetate and ethyl acetate tend to produce plate shaped crystals. CHZ crystals obtained from 2-ethoxyethylacetate tend to have plate shaped crystals with a lower aspect ratio and are selected for batch cooling crystallization experiments performed at different cooling rates, and agitation. It is found that the agitation at 300 rpm and the cooling rate 0.2ºC/min produce more uniform crystal size distribution. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211565 10.1590/s2175-97902023e20918 |
url |
https://www.revistas.usp.br/bjps/article/view/211565 |
identifier_str_mv |
10.1590/s2175-97902023e20918 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211565/194569 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e20918 Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e20918 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e20918 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222918017286144 |