Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/101507 https://doi.org/10.21614/sgo-25-3-113 |
Resumo: | Aim of the study: To systematically review the evidence regarding the association between portal venous pressure (PVP) after hepatectomy and posthepatectomy liver failure (PLHF) or other postsurgical outcomes. Materials and methods: We searched PubMed, Scopus and Web of Science for studies assessing post-hepatectomy PVP (or its variation) and reporting its association with PHLF or other postsurgical outcomes. We performed a random-effects meta-analysis for the association between development of PHLF and post-hepatectomy PVP and its variation. Heterogeneity was assessed using Q-Cochran test and I2 statistic. Quality assessment was performed considering ROBINS-1 Cochrane tool. Results: Four studies, assessing 439 patients, met the eligibility criteria and were included in this systematic review. The meta-analyses, including 3 studies, demonstrated that patients developing PHLF did not have a significantly higher post-hepatectomy PVP when compared to the remainder (1.98; 95%CI=-1.44-5.39; p=0.256; I2=2%), but had a significantly higher PVP variation (increase) during hepatectomy (1.65; 95%CI=1.15-2.15; p<0.001; I2=0%). The quality of the studies allowed to consider the robustness of the conclusions as “median”. Conclusions: An increased PVP variation following hepatectomy associates with a higher risk of PHLF, but the same was not observed for the absolute value of post-hepatectomy PVP. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
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Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysishepatobiliary surgeryliverportal venous pressureportal inflow modulationposthepatectomy liver failuremeta-analysisAim of the study: To systematically review the evidence regarding the association between portal venous pressure (PVP) after hepatectomy and posthepatectomy liver failure (PLHF) or other postsurgical outcomes. Materials and methods: We searched PubMed, Scopus and Web of Science for studies assessing post-hepatectomy PVP (or its variation) and reporting its association with PHLF or other postsurgical outcomes. We performed a random-effects meta-analysis for the association between development of PHLF and post-hepatectomy PVP and its variation. Heterogeneity was assessed using Q-Cochran test and I2 statistic. Quality assessment was performed considering ROBINS-1 Cochrane tool. Results: Four studies, assessing 439 patients, met the eligibility criteria and were included in this systematic review. The meta-analyses, including 3 studies, demonstrated that patients developing PHLF did not have a significantly higher post-hepatectomy PVP when compared to the remainder (1.98; 95%CI=-1.44-5.39; p=0.256; I2=2%), but had a significantly higher PVP variation (increase) during hepatectomy (1.65; 95%CI=1.15-2.15; p<0.001; I2=0%). The quality of the studies allowed to consider the robustness of the conclusions as “median”. Conclusions: An increased PVP variation following hepatectomy associates with a higher risk of PHLF, but the same was not observed for the absolute value of post-hepatectomy PVP.2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/101507http://hdl.handle.net/10316/101507https://doi.org/10.21614/sgo-25-3-113eng2559-723XMaciel Barbosa, JorgeTralhão, José GuilhermeBotelho, Maria FilomenaNunes Santos, JorgeSousa-Pinto, BernardoAbrantes, Ana MargaridaGomes Carrapita, Jorge Humbertoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-08-29T20:39:50Zoai:estudogeral.uc.pt:10316/101507Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:18:41.124072Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis |
title |
Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis |
spellingShingle |
Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis Maciel Barbosa, Jorge hepatobiliary surgery liver portal venous pressure portal inflow modulation posthepatectomy liver failure meta-analysis |
title_short |
Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis |
title_full |
Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis |
title_fullStr |
Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis |
title_sort |
Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis |
author |
Maciel Barbosa, Jorge |
author_facet |
Maciel Barbosa, Jorge Tralhão, José Guilherme Botelho, Maria Filomena Nunes Santos, Jorge Sousa-Pinto, Bernardo Abrantes, Ana Margarida Gomes Carrapita, Jorge Humberto |
author_role |
author |
author2 |
Tralhão, José Guilherme Botelho, Maria Filomena Nunes Santos, Jorge Sousa-Pinto, Bernardo Abrantes, Ana Margarida Gomes Carrapita, Jorge Humberto |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Maciel Barbosa, Jorge Tralhão, José Guilherme Botelho, Maria Filomena Nunes Santos, Jorge Sousa-Pinto, Bernardo Abrantes, Ana Margarida Gomes Carrapita, Jorge Humberto |
dc.subject.por.fl_str_mv |
hepatobiliary surgery liver portal venous pressure portal inflow modulation posthepatectomy liver failure meta-analysis |
topic |
hepatobiliary surgery liver portal venous pressure portal inflow modulation posthepatectomy liver failure meta-analysis |
description |
Aim of the study: To systematically review the evidence regarding the association between portal venous pressure (PVP) after hepatectomy and posthepatectomy liver failure (PLHF) or other postsurgical outcomes. Materials and methods: We searched PubMed, Scopus and Web of Science for studies assessing post-hepatectomy PVP (or its variation) and reporting its association with PHLF or other postsurgical outcomes. We performed a random-effects meta-analysis for the association between development of PHLF and post-hepatectomy PVP and its variation. Heterogeneity was assessed using Q-Cochran test and I2 statistic. Quality assessment was performed considering ROBINS-1 Cochrane tool. Results: Four studies, assessing 439 patients, met the eligibility criteria and were included in this systematic review. The meta-analyses, including 3 studies, demonstrated that patients developing PHLF did not have a significantly higher post-hepatectomy PVP when compared to the remainder (1.98; 95%CI=-1.44-5.39; p=0.256; I2=2%), but had a significantly higher PVP variation (increase) during hepatectomy (1.65; 95%CI=1.15-2.15; p<0.001; I2=0%). The quality of the studies allowed to consider the robustness of the conclusions as “median”. Conclusions: An increased PVP variation following hepatectomy associates with a higher risk of PHLF, but the same was not observed for the absolute value of post-hepatectomy PVP. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/101507 http://hdl.handle.net/10316/101507 https://doi.org/10.21614/sgo-25-3-113 |
url |
http://hdl.handle.net/10316/101507 https://doi.org/10.21614/sgo-25-3-113 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2559-723X |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799134081056768000 |