Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties

Detalhes bibliográficos
Autor(a) principal: Cefali, Letícia Caramori
Data de Publicação: 2019
Outros Autores: Ataide, Janaína Artem, Fernandes, Ana Rita, Sousa, Ilza Maria de Oliveira, Gonçalves, Fernanda Cristina da Silva, Eberlin, Samara, Dávila, José Luis, Jozala, Angela Faustino, Chaud, Marco Vinicius, Sánchez-López, Elena, Marto, Joana, d'Ávila, Marcos Akira, Ribeiro, Helena Margarida, Foglio, Mary Ann, Souto, Eliana B., Mazzola, Priscila Gava
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/106810
https://doi.org/10.3390/antiox8100443
Resumo: The aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant effect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor, antioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids were evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial analysis after loading the blend of extracts. The selected emulsion was stable when stored at low temperatures (5 C), for which after 120 days the concentration of quercetin and rutin were above their limit of quantification, i.e., 2.8 ± 0.39 µg/mL and 30.39 ± 0.39 µg/mL, respectively. Spreadability, low rupture strength and adhesiveness were shown to be similar to a conventional topical product. Higher brittleness, pseudo-plastic, and viscoelastic behaviors were also recorded for the developed phytocosmetic sunscreen. The product presented a critical wavelength of 387.0 nm and ultraviolet rays A and B (UVA/UVB) rate of 0.78, confirming that the developed formulation shows capacity for UVA/UVB protection, protecting skin against damages caused by Ultraviolet (UV) radiation. Rutin was shown to permeate the skin barrier and was also quantified in the stratum corneum (3.27 ± 1.92 µg/mL) by tape stripping and retention test (114.68 ± 8.70 µg/mL). The developed flavonoid-enriched phytocosmetic was shown to be non-irritant to skin by an in vitro assay. Our results confirm the antioxidant activity, sun protection, and physical properties of the developed phytocosmetic for topical application.
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spelling Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant PropertiesflavonoidsphytocosmeticemulsionantioxidantphotostabilitysunscreenThe aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant effect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor, antioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids were evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial analysis after loading the blend of extracts. The selected emulsion was stable when stored at low temperatures (5 C), for which after 120 days the concentration of quercetin and rutin were above their limit of quantification, i.e., 2.8 ± 0.39 µg/mL and 30.39 ± 0.39 µg/mL, respectively. Spreadability, low rupture strength and adhesiveness were shown to be similar to a conventional topical product. Higher brittleness, pseudo-plastic, and viscoelastic behaviors were also recorded for the developed phytocosmetic sunscreen. The product presented a critical wavelength of 387.0 nm and ultraviolet rays A and B (UVA/UVB) rate of 0.78, confirming that the developed formulation shows capacity for UVA/UVB protection, protecting skin against damages caused by Ultraviolet (UV) radiation. Rutin was shown to permeate the skin barrier and was also quantified in the stratum corneum (3.27 ± 1.92 µg/mL) by tape stripping and retention test (114.68 ± 8.70 µg/mL). The developed flavonoid-enriched phytocosmetic was shown to be non-irritant to skin by an in vitro assay. Our results confirm the antioxidant activity, sun protection, and physical properties of the developed phytocosmetic for topical application.MDPI2019-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106810http://hdl.handle.net/10316/106810https://doi.org/10.3390/antiox8100443eng2076-3921Cefali, Letícia CaramoriAtaide, Janaína ArtemFernandes, Ana RitaSousa, Ilza Maria de OliveiraGonçalves, Fernanda Cristina da SilvaEberlin, SamaraDávila, José LuisJozala, Angela FaustinoChaud, Marco ViniciusSánchez-López, ElenaMarto, Joanad'Ávila, Marcos AkiraRibeiro, Helena MargaridaFoglio, Mary AnnSouto, Eliana B.Mazzola, Priscila Gavainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-24T10:09:22Zoai:estudogeral.uc.pt:10316/106810Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:12.591594Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties
title Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties
spellingShingle Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties
Cefali, Letícia Caramori
flavonoids
phytocosmetic
emulsion
antioxidant
photostability
sunscreen
title_short Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties
title_full Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties
title_fullStr Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties
title_full_unstemmed Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties
title_sort Flavonoid-Enriched Plant-Extract-Loaded Emulsion: A Novel Phytocosmetic Sunscreen Formulation with Antioxidant Properties
author Cefali, Letícia Caramori
author_facet Cefali, Letícia Caramori
Ataide, Janaína Artem
Fernandes, Ana Rita
Sousa, Ilza Maria de Oliveira
Gonçalves, Fernanda Cristina da Silva
Eberlin, Samara
Dávila, José Luis
Jozala, Angela Faustino
Chaud, Marco Vinicius
Sánchez-López, Elena
Marto, Joana
d'Ávila, Marcos Akira
Ribeiro, Helena Margarida
Foglio, Mary Ann
Souto, Eliana B.
Mazzola, Priscila Gava
author_role author
author2 Ataide, Janaína Artem
Fernandes, Ana Rita
Sousa, Ilza Maria de Oliveira
Gonçalves, Fernanda Cristina da Silva
Eberlin, Samara
Dávila, José Luis
Jozala, Angela Faustino
Chaud, Marco Vinicius
Sánchez-López, Elena
Marto, Joana
d'Ávila, Marcos Akira
Ribeiro, Helena Margarida
Foglio, Mary Ann
Souto, Eliana B.
Mazzola, Priscila Gava
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cefali, Letícia Caramori
Ataide, Janaína Artem
Fernandes, Ana Rita
Sousa, Ilza Maria de Oliveira
Gonçalves, Fernanda Cristina da Silva
Eberlin, Samara
Dávila, José Luis
Jozala, Angela Faustino
Chaud, Marco Vinicius
Sánchez-López, Elena
Marto, Joana
d'Ávila, Marcos Akira
Ribeiro, Helena Margarida
Foglio, Mary Ann
Souto, Eliana B.
Mazzola, Priscila Gava
dc.subject.por.fl_str_mv flavonoids
phytocosmetic
emulsion
antioxidant
photostability
sunscreen
topic flavonoids
phytocosmetic
emulsion
antioxidant
photostability
sunscreen
description The aim of this study was to develop a phytocosmetic sunscreen emulsion with antioxidant effect, containing a blend of flavonoid-enriched plant extracts. In vitro sun protection factor, antioxidant activity, skin irritation, photostability, cutaneous permeation, and retention of flavonoids were evaluated. Thermodynamically stable emulsions were obtained and tested for sensorial analysis after loading the blend of extracts. The selected emulsion was stable when stored at low temperatures (5 C), for which after 120 days the concentration of quercetin and rutin were above their limit of quantification, i.e., 2.8 ± 0.39 µg/mL and 30.39 ± 0.39 µg/mL, respectively. Spreadability, low rupture strength and adhesiveness were shown to be similar to a conventional topical product. Higher brittleness, pseudo-plastic, and viscoelastic behaviors were also recorded for the developed phytocosmetic sunscreen. The product presented a critical wavelength of 387.0 nm and ultraviolet rays A and B (UVA/UVB) rate of 0.78, confirming that the developed formulation shows capacity for UVA/UVB protection, protecting skin against damages caused by Ultraviolet (UV) radiation. Rutin was shown to permeate the skin barrier and was also quantified in the stratum corneum (3.27 ± 1.92 µg/mL) by tape stripping and retention test (114.68 ± 8.70 µg/mL). The developed flavonoid-enriched phytocosmetic was shown to be non-irritant to skin by an in vitro assay. Our results confirm the antioxidant activity, sun protection, and physical properties of the developed phytocosmetic for topical application.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/106810
http://hdl.handle.net/10316/106810
https://doi.org/10.3390/antiox8100443
url http://hdl.handle.net/10316/106810
https://doi.org/10.3390/antiox8100443
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3921
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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