Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody

Detalhes bibliográficos
Autor(a) principal: Santos,Sofia
Data de Publicação: 2017
Outros Autores: Castro,Ana, Campos,Andreia, Pedroso,Sofia, Dias,Leonídio, Henriques,Castro
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007
Resumo: We report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapies
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spelling Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibodyDonor-specific antibodiesanti-HLA-Cw antibodiesantibody-mediated rejectionWe report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapiesSociedade Portuguesa de Nefrologia2017-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007Portuguese Journal of Nephrology & Hypertension v.31 n.1 2017reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007Santos,SofiaCastro,AnaCampos,AndreiaPedroso,SofiaDias,LeonídioHenriques,Castroinfo:eu-repo/semantics/openAccess2024-02-06T17:04:54Zoai:scielo:S0872-01692017000100007Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:58.079434Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody
title Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody
spellingShingle Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody
Santos,Sofia
Donor-specific antibodies
anti-HLA-Cw antibodies
antibody-mediated rejection
title_short Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody
title_full Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody
title_fullStr Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody
title_full_unstemmed Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody
title_sort Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody
author Santos,Sofia
author_facet Santos,Sofia
Castro,Ana
Campos,Andreia
Pedroso,Sofia
Dias,Leonídio
Henriques,Castro
author_role author
author2 Castro,Ana
Campos,Andreia
Pedroso,Sofia
Dias,Leonídio
Henriques,Castro
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santos,Sofia
Castro,Ana
Campos,Andreia
Pedroso,Sofia
Dias,Leonídio
Henriques,Castro
dc.subject.por.fl_str_mv Donor-specific antibodies
anti-HLA-Cw antibodies
antibody-mediated rejection
topic Donor-specific antibodies
anti-HLA-Cw antibodies
antibody-mediated rejection
description We report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapies
publishDate 2017
dc.date.none.fl_str_mv 2017-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.31 n.1 2017
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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