Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007 |
Resumo: | We report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapies |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibodyDonor-specific antibodiesanti-HLA-Cw antibodiesantibody-mediated rejectionWe report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapiesSociedade Portuguesa de Nefrologia2017-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007Portuguese Journal of Nephrology & Hypertension v.31 n.1 2017reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007Santos,SofiaCastro,AnaCampos,AndreiaPedroso,SofiaDias,LeonídioHenriques,Castroinfo:eu-repo/semantics/openAccess2024-02-06T17:04:54Zoai:scielo:S0872-01692017000100007Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:58.079434Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody |
title |
Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody |
spellingShingle |
Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody Santos,Sofia Donor-specific antibodies anti-HLA-Cw antibodies antibody-mediated rejection |
title_short |
Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody |
title_full |
Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody |
title_fullStr |
Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody |
title_full_unstemmed |
Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody |
title_sort |
Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw donor specific antibody |
author |
Santos,Sofia |
author_facet |
Santos,Sofia Castro,Ana Campos,Andreia Pedroso,Sofia Dias,Leonídio Henriques,Castro |
author_role |
author |
author2 |
Castro,Ana Campos,Andreia Pedroso,Sofia Dias,Leonídio Henriques,Castro |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos,Sofia Castro,Ana Campos,Andreia Pedroso,Sofia Dias,Leonídio Henriques,Castro |
dc.subject.por.fl_str_mv |
Donor-specific antibodies anti-HLA-Cw antibodies antibody-mediated rejection |
topic |
Donor-specific antibodies anti-HLA-Cw antibodies antibody-mediated rejection |
description |
We report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HLA A/B/DR/DQ. Thus we should take HLA-C typing and respective antibody identification into account in sensitized patients, in order to access risk stratification and establish the need for correct induction or desensitization therapies |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
dc.source.none.fl_str_mv |
Portuguese Journal of Nephrology & Hypertension v.31 n.1 2017 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137279659212800 |