Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex

Detalhes bibliográficos
Autor(a) principal: Singh,Birjesh
Data de Publicação: 2015
Outros Autores: Mishra,Jyotsna, Pradhan,Alka
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042015000600002
Resumo: Cobalt complex with flutamide was synthesized and physico-chemically characterized by amperometry, polarography, elemental analysis and IR spectrometry. After synthesizing the metal complex, it was evaluated for antibacterial and antifungal activities against various pathogenic microorganisms such as Streptococcus aureus, Prosteus mirabilis, Klebsiella pneumonia and Aspergillus niger, Nigrosporan sp Fungi. B16-F10 melanoma cell and C-57BL/6 mice have been used for anticancer screening of the metal complex for in vitro and in vivo study. The result of pharmacological studies with M:L revealed that the complex is more potent as compared to the pure drug as regards to its anticancer activity.
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spelling Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide ComplexAnticancer drugCobalt ComplexPolarographyAntibacterial activityPharmacologyCobalt complex with flutamide was synthesized and physico-chemically characterized by amperometry, polarography, elemental analysis and IR spectrometry. After synthesizing the metal complex, it was evaluated for antibacterial and antifungal activities against various pathogenic microorganisms such as Streptococcus aureus, Prosteus mirabilis, Klebsiella pneumonia and Aspergillus niger, Nigrosporan sp Fungi. B16-F10 melanoma cell and C-57BL/6 mice have been used for anticancer screening of the metal complex for in vitro and in vivo study. The result of pharmacological studies with M:L revealed that the complex is more potent as compared to the pure drug as regards to its anticancer activity.Sociedade Portuguesa de Electroquímica2015-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042015000600002Portugaliae Electrochimica Acta v.33 n.6 2015reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042015000600002Singh,BirjeshMishra,JyotsnaPradhan,Alkainfo:eu-repo/semantics/openAccess2024-02-06T17:07:20Zoai:scielo:S0872-19042015000600002Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:17.628262Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex
title Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex
spellingShingle Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex
Singh,Birjesh
Anticancer drug
Cobalt Complex
Polarography
Antibacterial activity
Pharmacology
title_short Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex
title_full Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex
title_fullStr Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex
title_full_unstemmed Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex
title_sort Synthesis Characterization and Anticancer Activity of Co(II)-Flutamide Complex
author Singh,Birjesh
author_facet Singh,Birjesh
Mishra,Jyotsna
Pradhan,Alka
author_role author
author2 Mishra,Jyotsna
Pradhan,Alka
author2_role author
author
dc.contributor.author.fl_str_mv Singh,Birjesh
Mishra,Jyotsna
Pradhan,Alka
dc.subject.por.fl_str_mv Anticancer drug
Cobalt Complex
Polarography
Antibacterial activity
Pharmacology
topic Anticancer drug
Cobalt Complex
Polarography
Antibacterial activity
Pharmacology
description Cobalt complex with flutamide was synthesized and physico-chemically characterized by amperometry, polarography, elemental analysis and IR spectrometry. After synthesizing the metal complex, it was evaluated for antibacterial and antifungal activities against various pathogenic microorganisms such as Streptococcus aureus, Prosteus mirabilis, Klebsiella pneumonia and Aspergillus niger, Nigrosporan sp Fungi. B16-F10 melanoma cell and C-57BL/6 mice have been used for anticancer screening of the metal complex for in vitro and in vivo study. The result of pharmacological studies with M:L revealed that the complex is more potent as compared to the pure drug as regards to its anticancer activity.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042015000600002
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042015000600002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042015000600002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
dc.source.none.fl_str_mv Portugaliae Electrochimica Acta v.33 n.6 2015
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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