DIABETES AND THE FUTURE OF TREATMENT
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.25756/rpf.v7i4.98 |
Resumo: | The prevalence of diabetes has been increasing alarmingly, with a significant proportion of cases remaining undiagnosed. The pharmaceutical industry, research laboratories and technology have a key role in finding new solutions that optimize diabetes treatment and reduce complications, with improvement of quality of life. This review aims to briefly present the novelties and hopes in the pharmaceutical, biological and technological field. Regarding insulin therapy, intensive research is currently being made on “smart insulins”, with future repercussions, and biosimilar versions of insulin glargine are also being developed. In the future, nanotechnology could revolutionize the treatment of diabetes, for its application in drug therapy, with oral insulin, and application in monitoring blood glucose. For the treatment of type 2 diabetes, new molecules are being developed and existing drugs are being modified in order to increase the duration of action, improve drug combination and reduce known adverse effects. Moreover, new therapeutic approaches are being further developed, including adipose tissue transplant/regeneration strategies, reprogramming of different cell types, “digital pancreas” and the use of digital technologies to control glycaemia. Investment in research programs is important not only to find suitable means of prevention and cure, but also to develop better treatment strategies. It can be considered that the intervention in diabetes, concerted in various fields, has given important steps, but there is still a long way to go. |
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DIABETES AND THE FUTURE OF TREATMENTDIABETES E O FUTURO DO TRATAMENTOThe prevalence of diabetes has been increasing alarmingly, with a significant proportion of cases remaining undiagnosed. The pharmaceutical industry, research laboratories and technology have a key role in finding new solutions that optimize diabetes treatment and reduce complications, with improvement of quality of life. This review aims to briefly present the novelties and hopes in the pharmaceutical, biological and technological field. Regarding insulin therapy, intensive research is currently being made on “smart insulins”, with future repercussions, and biosimilar versions of insulin glargine are also being developed. In the future, nanotechnology could revolutionize the treatment of diabetes, for its application in drug therapy, with oral insulin, and application in monitoring blood glucose. For the treatment of type 2 diabetes, new molecules are being developed and existing drugs are being modified in order to increase the duration of action, improve drug combination and reduce known adverse effects. Moreover, new therapeutic approaches are being further developed, including adipose tissue transplant/regeneration strategies, reprogramming of different cell types, “digital pancreas” and the use of digital technologies to control glycaemia. Investment in research programs is important not only to find suitable means of prevention and cure, but also to develop better treatment strategies. It can be considered that the intervention in diabetes, concerted in various fields, has given important steps, but there is still a long way to go.A prevalência de diabetes tem vindo a aumentar de forma preocupante, sendo que uma percentagem significativa de casos permanece por diagnosticar. A indústria farmacêutica, os laboratórios de investigação e a tecnologia têm, neste caso, um papel fundamental na procura de soluções que otimizem o tratamento da diabetes e reduzam as complicações, com melhoria da qualidade de vida. A presente revisão tem como objetivo apresentar, resumidamente, as novidades e as esperanças no domínio das soluções farmacológicas, biológicas e tecnológicas. No âmbito da insulinoterapia, decorre atualmente investigação intensa nas chamadas smart insulins, as quais terão repercussões futuras de relevo, estando também a ser desenvolvidas versões biossimilares da insulina glargina. No futuro, a nanotecnologia poderá revolucionar o tratamento da diabetes, pela sua aplicação na terapêutica farmacológica, com o uso da insulina oral, e na monitorização da glicemia. Relativamente ao tratamento da diabetes mellitus tipo 2 estão a ser desenvolvidas novas moléculas ou modificadas as já existentes, com o objetivo de aumentar o tempo de ação, melhorar a combinação de fármacos e reduzir os efeitos adversos conhecidos. Por outro lado, novas abordagens terapêuticas estão a ser aprofundadas, nomeadamente estratégias de transplantação/regeneração de tecido adiposo, reprogramação de diferentes tipos celulares, «pâncreas digital» e utilização de tecnologias digitais para o controlo glicémico. A aposta em programas de investigação é importante não só para descobrir meios adequados de prevenção e de cura, mas também para desenvolver melhores estratégias de tratamento. Poderemos dizer que a intervenção na diabetes, concertada nos vários domínios, tem vindo a dar passos importantes, mas ainda há um longo caminho a percorrer.Formifarma2016-03-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.25756/rpf.v7i4.98https://doi.org/10.25756/rpf.v7i4.98Revista Portuguesa de Farmacoterapia / Portuguese Journal of Pharmacotherapy; Vol 7 No 4 (2015): Outubro; 221-229Revista Portuguesa de Farmacoterapia; v. 7 n. 4 (2015): Outubro; 221-2292183-73411647-354Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttp://revista.farmacoterapia.pt/index.php/rpf/article/view/98http://revista.farmacoterapia.pt/index.php/rpf/article/view/98/83Direitos de Autor (c) 2017 Revista Portuguesa de Farmacoterapiahttp://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessMedina, José LuisSouto, SelmaFerreira, Joana2023-09-01T04:33:29Zoai:ojs.farmacoterapia.pt:article/98Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:11:33.981142Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
DIABETES AND THE FUTURE OF TREATMENT DIABETES E O FUTURO DO TRATAMENTO |
title |
DIABETES AND THE FUTURE OF TREATMENT |
spellingShingle |
DIABETES AND THE FUTURE OF TREATMENT Medina, José Luis |
title_short |
DIABETES AND THE FUTURE OF TREATMENT |
title_full |
DIABETES AND THE FUTURE OF TREATMENT |
title_fullStr |
DIABETES AND THE FUTURE OF TREATMENT |
title_full_unstemmed |
DIABETES AND THE FUTURE OF TREATMENT |
title_sort |
DIABETES AND THE FUTURE OF TREATMENT |
author |
Medina, José Luis |
author_facet |
Medina, José Luis Souto, Selma Ferreira, Joana |
author_role |
author |
author2 |
Souto, Selma Ferreira, Joana |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Medina, José Luis Souto, Selma Ferreira, Joana |
description |
The prevalence of diabetes has been increasing alarmingly, with a significant proportion of cases remaining undiagnosed. The pharmaceutical industry, research laboratories and technology have a key role in finding new solutions that optimize diabetes treatment and reduce complications, with improvement of quality of life. This review aims to briefly present the novelties and hopes in the pharmaceutical, biological and technological field. Regarding insulin therapy, intensive research is currently being made on “smart insulins”, with future repercussions, and biosimilar versions of insulin glargine are also being developed. In the future, nanotechnology could revolutionize the treatment of diabetes, for its application in drug therapy, with oral insulin, and application in monitoring blood glucose. For the treatment of type 2 diabetes, new molecules are being developed and existing drugs are being modified in order to increase the duration of action, improve drug combination and reduce known adverse effects. Moreover, new therapeutic approaches are being further developed, including adipose tissue transplant/regeneration strategies, reprogramming of different cell types, “digital pancreas” and the use of digital technologies to control glycaemia. Investment in research programs is important not only to find suitable means of prevention and cure, but also to develop better treatment strategies. It can be considered that the intervention in diabetes, concerted in various fields, has given important steps, but there is still a long way to go. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-12 |
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info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.25756/rpf.v7i4.98 https://doi.org/10.25756/rpf.v7i4.98 |
url |
https://doi.org/10.25756/rpf.v7i4.98 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
http://revista.farmacoterapia.pt/index.php/rpf/article/view/98 http://revista.farmacoterapia.pt/index.php/rpf/article/view/98/83 |
dc.rights.driver.fl_str_mv |
Direitos de Autor (c) 2017 Revista Portuguesa de Farmacoterapia http://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos de Autor (c) 2017 Revista Portuguesa de Farmacoterapia http://creativecommons.org/licenses/by-nc-nd/4.0 |
eu_rights_str_mv |
openAccess |
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application/pdf |
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Formifarma |
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Formifarma |
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Revista Portuguesa de Farmacoterapia / Portuguese Journal of Pharmacotherapy; Vol 7 No 4 (2015): Outubro; 221-229 Revista Portuguesa de Farmacoterapia; v. 7 n. 4 (2015): Outubro; 221-229 2183-7341 1647-354X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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