Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccination

• Autor(a) principal: Gonçalves, Juliana
• Data de Publicação: 2021
• Outros Autores: Juliano, A. Margarida, Charepe, Nádia, Alenquer, Marta, Athayde, Diogo, Ferreira, Filipe, Archer, Margarida, Amorim, Maria João, Serrano, Fátima, Soares, Helena
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/132654
• topic: breastmilk T cells; COVID-19; lactating women; maternal vaccination; memory B cells; milk-transferred SARS-CoV-2 protection; milk-transferred spike-reactive T cells; mRNA vaccine; plasmablasts; spike SIgA; Biochemistry, Genetics and Molecular Biology(all); Medicine(all); SDG 3 - Good Health and Well-being

Funding Information: We are very grateful to all study participants. We thank Cl?udia Andrade (CEDOC Flow Cytometry Platform), Manuela Correia, Yasmina Orraca, Daniela Silva, and Jos? Ramalho for support. This work was supported by European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and by Gilead G?nese (PGG/009/2017) grants to H.S. RESEARCH 4 COVID-19 to M.J.A. European Union (EU) Horizon 2020 (H2020) grants 823780 and 87103, and Funda??o para a Ci?ncia e Tecnologia (FCT) MOSTMICRO-ITQB grants UIDB/04612/2020 and UIDP/04612/2020 to M. Archer and D.A. J.G. D.A. M.J.A. and H.S. are supported by FCT through grants PD/BD/128343/2017 and 02/SAICT/2020/072552, BD/147987/2019, CEECIND/02373/2020, and CEECIND/01049/2020, respectively. The graphical abstract was created using BioRender.com. J.G. A.M.J. M. Alenquer, D.A. and F.F. designed and performed experiments and analyzed the data. N.C. F.S. J.G. and H.S. enrolled the subjects and collected demographic data. M.J.A. and M. Archer provided critical expertise. H.S. conceptualized the study, designed experiments, analyzed the data, supervised the project, and wrote the manuscript. All authors discussed the results and commented on the manuscript. The authors declare no competing interests. Funding Information: We are very grateful to all study participants. We thank Cláudia Andrade (CEDOC Flow Cytometry Platform), Manuela Correia, Yasmina Orraca, Daniela Silva, and José Ramalho for support. This work was supported by European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and by Gilead Génese ( PGG/009/2017 ) grants to H.S., RESEARCH 4 COVID-19 to M.J.A., European Union (EU) Horizon 2020 (H2020) grants 823780 and 87103 , and Fundação para a Ciência e Tecnologia (FCT) MOSTMICRO-ITQB grants UIDB/04612/2020 and UIDP/04612/2020 to M. Archer and D.A. J.G., D.A., M.J.A., and H.S. are supported by FCT through grants PD/BD/128343/2017 and 02/SAICT/2020/072552 , BD/147987/2019 , CEECIND/02373/2020 , and CEECIND/01049/2020 , respectively. The graphical abstract was created using BioRender.com .