Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/74857 |
Resumo: | The increasing rate of musculoskeletal pathologies has compelled the development of improved and novel treatment strategies in order to address unmet clinical needs. Tissue engineering approaches comprising the use of scaffolds for bone regeneration have been showing to be a promising alternative to conventional bone repair/substitution approaches. In particular, hierarchical scaffolds as methods of structural support and osteogenic differentiation promoters are among the most used tools in bone tissue engineering (BTE). In this reasoning, hierarchical scaffolds have sparked the field, striving toward mimicking the natural bone tissue in both, its complex 3D structure and composition. A recent and promising trend has been the merging of nanotechnology and tissue engineering concepts. As such the incorporation of nanoparticles and nanocomposites into micro- or macroscaffold systems can result in an improvement of scaffoldsâ biofunctionality at different levels. These tools are versatile in nature and can be used for multiple purposes such as drug delivery, thermal conductors, and mechanical reinforcement. Taking into consideration multidisciplinary approaches, several strategies have been pursued. The recent reports dealing with the approaches pursued in the hierarchical scaffolds production and enhancement, ranging from the nanoscale to the macroscale, are overviewed herein. |
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Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineeringBiomaterialsBoneMicroparticlesNanocompositesNanoparticlesScience & TechnologyThe increasing rate of musculoskeletal pathologies has compelled the development of improved and novel treatment strategies in order to address unmet clinical needs. Tissue engineering approaches comprising the use of scaffolds for bone regeneration have been showing to be a promising alternative to conventional bone repair/substitution approaches. In particular, hierarchical scaffolds as methods of structural support and osteogenic differentiation promoters are among the most used tools in bone tissue engineering (BTE). In this reasoning, hierarchical scaffolds have sparked the field, striving toward mimicking the natural bone tissue in both, its complex 3D structure and composition. A recent and promising trend has been the merging of nanotechnology and tissue engineering concepts. As such the incorporation of nanoparticles and nanocomposites into micro- or macroscaffold systems can result in an improvement of scaffoldsâ biofunctionality at different levels. These tools are versatile in nature and can be used for multiple purposes such as drug delivery, thermal conductors, and mechanical reinforcement. Taking into consideration multidisciplinary approaches, several strategies have been pursued. The recent reports dealing with the approaches pursued in the hierarchical scaffolds production and enhancement, ranging from the nanoscale to the macroscale, are overviewed herein.The authors thank the funds provided by the project FROnTHERA (NORTE-01-0145-FEDER-000023), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), the project 3BioMeD (FCT/4773/ 4/5/2017/S) supported by Fundação para a Ciência e a Tecnologia (FCT) and the R&D Project KOAT PTDC/BTMMAT/29760/2017 (POCI 01-0145-FEDER-029760) financed by FCT and cofinanced by FEDER and POCI. F.R.M. acknowledges FCT for her contract under the Transitional Rule DL 57/2016 (CTTI-57/18-I3BS (5)).WileyUniversidade do MinhoLemos, RafaelMaia, F. RaquelReis, R. L.Oliveira, J. M.20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/74857engLemos R., Maia F. R., Reis R. L., Oliveira J. M. Engineering of Extracellular Matrix-Like Biomaterials at Nano- and Macroscale toward Fabrication of Hierarchical Scaffolds for Bone Tissue Engineering, Advanced NanoBiomed Research, doi:10.1002/anbr.202100116, 20212699-930710.1002/anbr.202100116https://onlinelibrary.wiley.com/doi/10.1002/anbr.202100116info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:53:46Zoai:repositorium.sdum.uminho.pt:1822/74857Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:53:13.643659Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering |
title |
Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering |
spellingShingle |
Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering Lemos, Rafael Biomaterials Bone Microparticles Nanocomposites Nanoparticles Science & Technology |
title_short |
Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering |
title_full |
Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering |
title_fullStr |
Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering |
title_full_unstemmed |
Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering |
title_sort |
Engineering of extracellular matrix-like biomaterials at nano- and macroscale toward fabrication of hierarchical scaffolds for bone tissue engineering |
author |
Lemos, Rafael |
author_facet |
Lemos, Rafael Maia, F. Raquel Reis, R. L. Oliveira, J. M. |
author_role |
author |
author2 |
Maia, F. Raquel Reis, R. L. Oliveira, J. M. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Lemos, Rafael Maia, F. Raquel Reis, R. L. Oliveira, J. M. |
dc.subject.por.fl_str_mv |
Biomaterials Bone Microparticles Nanocomposites Nanoparticles Science & Technology |
topic |
Biomaterials Bone Microparticles Nanocomposites Nanoparticles Science & Technology |
description |
The increasing rate of musculoskeletal pathologies has compelled the development of improved and novel treatment strategies in order to address unmet clinical needs. Tissue engineering approaches comprising the use of scaffolds for bone regeneration have been showing to be a promising alternative to conventional bone repair/substitution approaches. In particular, hierarchical scaffolds as methods of structural support and osteogenic differentiation promoters are among the most used tools in bone tissue engineering (BTE). In this reasoning, hierarchical scaffolds have sparked the field, striving toward mimicking the natural bone tissue in both, its complex 3D structure and composition. A recent and promising trend has been the merging of nanotechnology and tissue engineering concepts. As such the incorporation of nanoparticles and nanocomposites into micro- or macroscaffold systems can result in an improvement of scaffoldsâ biofunctionality at different levels. These tools are versatile in nature and can be used for multiple purposes such as drug delivery, thermal conductors, and mechanical reinforcement. Taking into consideration multidisciplinary approaches, several strategies have been pursued. The recent reports dealing with the approaches pursued in the hierarchical scaffolds production and enhancement, ranging from the nanoscale to the macroscale, are overviewed herein. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/74857 |
url |
https://hdl.handle.net/1822/74857 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lemos R., Maia F. R., Reis R. L., Oliveira J. M. Engineering of Extracellular Matrix-Like Biomaterials at Nano- and Macroscale toward Fabrication of Hierarchical Scaffolds for Bone Tissue Engineering, Advanced NanoBiomed Research, doi:10.1002/anbr.202100116, 2021 2699-9307 10.1002/anbr.202100116 https://onlinelibrary.wiley.com/doi/10.1002/anbr.202100116 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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