Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution

Detalhes bibliográficos
Autor(a) principal: Paulo, Tânia F.
Data de Publicação: 2016
Outros Autores: Nolte, Viola, Schlötterer, Christian, Sucena, Élio, Teixeira, Luis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/699
Resumo: Microbial symbionts can modulate host interactions with biotic and abiotic factors. Such interactions may affect the evolutionary trajectories of both host and symbiont. Wolbachia protects Drosophila melanogaster against several viral infections and the strength of the protection varies between variants of this endosymbiont. Since Wolbachia is maternally transmitted, its fitness depends on the fitness of its host. Therefore, Wolbachia populations may be under selection when Drosophila is subjected to viral infection. Here we show that in D. melanogaster populations selected for increased survival upon infection with Drosophila C virus there is a strong selection coefficient for specific Wolbachia variants, leading to their fixation. Flies carrying these selected Wolbachia variants have higher survival and fertility upon viral infection when compared to flies with the other variants. These findings demonstrate how the interaction of a host with pathogens shapes the genetic composition of symbiont populations. Furthermore, host adaptation can result from the evolution of its symbionts, with host and symbiont functioning as a single evolutionary unit.
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spelling Drosophila Adaptation to Viral Infection through Defensive Symbiont EvolutionWolbachiaHost-pathogen interactionsDrosophila melanogasterViral evolutionViral transmission and infectionParasite evolutionNatural selectionMicrobial evolutionMicrobial symbionts can modulate host interactions with biotic and abiotic factors. Such interactions may affect the evolutionary trajectories of both host and symbiont. Wolbachia protects Drosophila melanogaster against several viral infections and the strength of the protection varies between variants of this endosymbiont. Since Wolbachia is maternally transmitted, its fitness depends on the fitness of its host. Therefore, Wolbachia populations may be under selection when Drosophila is subjected to viral infection. Here we show that in D. melanogaster populations selected for increased survival upon infection with Drosophila C virus there is a strong selection coefficient for specific Wolbachia variants, leading to their fixation. Flies carrying these selected Wolbachia variants have higher survival and fertility upon viral infection when compared to flies with the other variants. These findings demonstrate how the interaction of a host with pathogens shapes the genetic composition of symbiont populations. Furthermore, host adaptation can result from the evolution of its symbionts, with host and symbiont functioning as a single evolutionary unit.Austrian Science Funds grant: (FWF P27630).Public Library of ScienceARCAPaulo, Tânia F.Nolte, ViolaSchlötterer, ChristianSucena, ÉlioTeixeira, Luis2016-10-10T15:15:29Z2016-09-292016-09-29T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tifftext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plaintext/plainhttp://hdl.handle.net/10400.7/699engFaria VG, Martins NE, PauloTF, Magalhães S, NolteV, Schlötte rer C, et al. (2016) Drosophila Adaptati on to Viral Infection through Defensive Symbiont Evolution. PLoS Genet 12(9): e1006297. doi:10.1371 /journal. pgen.100629710.1371/journal.pgen.1006297info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:05Zoai:arca.igc.gulbenkian.pt:10400.7/699Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:55.899306Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution
title Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution
spellingShingle Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution
Paulo, Tânia F.
Wolbachia
Host-pathogen interactions
Drosophila melanogaster
Viral evolution
Viral transmission and infection
Parasite evolution
Natural selection
Microbial evolution
title_short Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution
title_full Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution
title_fullStr Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution
title_full_unstemmed Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution
title_sort Drosophila Adaptation to Viral Infection through Defensive Symbiont Evolution
author Paulo, Tânia F.
author_facet Paulo, Tânia F.
Nolte, Viola
Schlötterer, Christian
Sucena, Élio
Teixeira, Luis
author_role author
author2 Nolte, Viola
Schlötterer, Christian
Sucena, Élio
Teixeira, Luis
author2_role author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Paulo, Tânia F.
Nolte, Viola
Schlötterer, Christian
Sucena, Élio
Teixeira, Luis
dc.subject.por.fl_str_mv Wolbachia
Host-pathogen interactions
Drosophila melanogaster
Viral evolution
Viral transmission and infection
Parasite evolution
Natural selection
Microbial evolution
topic Wolbachia
Host-pathogen interactions
Drosophila melanogaster
Viral evolution
Viral transmission and infection
Parasite evolution
Natural selection
Microbial evolution
description Microbial symbionts can modulate host interactions with biotic and abiotic factors. Such interactions may affect the evolutionary trajectories of both host and symbiont. Wolbachia protects Drosophila melanogaster against several viral infections and the strength of the protection varies between variants of this endosymbiont. Since Wolbachia is maternally transmitted, its fitness depends on the fitness of its host. Therefore, Wolbachia populations may be under selection when Drosophila is subjected to viral infection. Here we show that in D. melanogaster populations selected for increased survival upon infection with Drosophila C virus there is a strong selection coefficient for specific Wolbachia variants, leading to their fixation. Flies carrying these selected Wolbachia variants have higher survival and fertility upon viral infection when compared to flies with the other variants. These findings demonstrate how the interaction of a host with pathogens shapes the genetic composition of symbiont populations. Furthermore, host adaptation can result from the evolution of its symbionts, with host and symbiont functioning as a single evolutionary unit.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-10T15:15:29Z
2016-09-29
2016-09-29T00:00:00Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/699
url http://hdl.handle.net/10400.7/699
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Faria VG, Martins NE, PauloTF, Magalhães S, NolteV, Schlötte rer C, et al. (2016) Drosophila Adaptati on to Viral Infection through Defensive Symbiont Evolution. PLoS Genet 12(9): e1006297. doi:10.1371 /journal. pgen.1006297
10.1371/journal.pgen.1006297
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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