The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility

Detalhes bibliográficos
Autor(a) principal: Cristelo, Cecília Silva
Data de Publicação: 2021
Outros Autores: Machado, Fátima Alexandra Meira, Sarmento, Bruno, Gama, F. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/70370
Resumo: Type 1 diabetes has increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type 1 diabetes by mediating the interplay between the gut microbiome, the immune system and cell function. While its potential on type 1 diabetes treatment seems high, the understanding of its effects is still limited. This review aims to contribute to a more comprehensive understanding of the potential of vitamin D and cathelicidin as adjuvants in type 1 diabetes therapy.
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spelling The roles of vitamin D and cathelicidin in type 1 diabetes susceptibilityß cell protectionCathelicidinDiabetesImmunomodulationVitamin Dβ cell protectionScience & TechnologyType 1 diabetes has increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type 1 diabetes by mediating the interplay between the gut microbiome, the immune system and cell function. While its potential on type 1 diabetes treatment seems high, the understanding of its effects is still limited. This review aims to contribute to a more comprehensive understanding of the potential of vitamin D and cathelicidin as adjuvants in type 1 diabetes therapy.This work was financed by FEDER – Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 – Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT – Fundação para a Ciência e a Tecnologia/ Ministério da Ciência, Tecnologia e Ensino Superior in the framework of the project PTDC/MED-OUT/30466/2017 and ‘Institute for Research and Innovation in Health Sciences’ (FCT – UID/BIM/04293/2019). Cecília Cristelo and Alexandra Machado would like to thank to Fundação para a Ciência e a Tecnologia (FCT), Portugal for financial support (SFRH/BD/139402/2018 and SFRH/BD132000/2017, respectively).info:eu-repo/semantics/publishedVersionBioscientificaUniversidade do MinhoCristelo, Cecília SilvaMachado, Fátima Alexandra MeiraSarmento, BrunoGama, F. M.20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/70370engCristelo, C.; Machado, A.; Sarmento, Bruno; Gama, F. M., The roles of vitamin D and cathelicidin on type 1 diabetes susceptibility. Endocrine Connections, 10(1), R1-R12, 20212049-361410.1530/EC-20-0484https://ec.bioscientifica.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:50:21Zoai:repositorium.sdum.uminho.pt:1822/70370Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:49:03.412497Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility
title The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility
spellingShingle The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility
Cristelo, Cecília Silva
ß cell protection
Cathelicidin
Diabetes
Immunomodulation
Vitamin D
β cell protection
Science & Technology
title_short The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility
title_full The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility
title_fullStr The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility
title_full_unstemmed The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility
title_sort The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility
author Cristelo, Cecília Silva
author_facet Cristelo, Cecília Silva
Machado, Fátima Alexandra Meira
Sarmento, Bruno
Gama, F. M.
author_role author
author2 Machado, Fátima Alexandra Meira
Sarmento, Bruno
Gama, F. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Cristelo, Cecília Silva
Machado, Fátima Alexandra Meira
Sarmento, Bruno
Gama, F. M.
dc.subject.por.fl_str_mv ß cell protection
Cathelicidin
Diabetes
Immunomodulation
Vitamin D
β cell protection
Science & Technology
topic ß cell protection
Cathelicidin
Diabetes
Immunomodulation
Vitamin D
β cell protection
Science & Technology
description Type 1 diabetes has increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type 1 diabetes by mediating the interplay between the gut microbiome, the immune system and cell function. While its potential on type 1 diabetes treatment seems high, the understanding of its effects is still limited. This review aims to contribute to a more comprehensive understanding of the potential of vitamin D and cathelicidin as adjuvants in type 1 diabetes therapy.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/70370
url http://hdl.handle.net/1822/70370
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cristelo, C.; Machado, A.; Sarmento, Bruno; Gama, F. M., The roles of vitamin D and cathelicidin on type 1 diabetes susceptibility. Endocrine Connections, 10(1), R1-R12, 2021
2049-3614
10.1530/EC-20-0484
https://ec.bioscientifica.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bioscientifica
publisher.none.fl_str_mv Bioscientifica
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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