The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion Hydrochloride

Detalhes bibliográficos
Autor(a) principal: Samota,Sharda
Data de Publicação: 2010
Outros Autores: Garg,Ashish, Pandey,Rajayashree
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042010000200002
Resumo: The electroreduction of the antidepressant drug Bupropion hydrochloride has been studied in aqueous media at dme. Single well defined wave was obtained in different supporting electrolytes, like, KNO3, ammonium citrate buffer, acetate buffer, B. R. buffer, etc. The effect of pH on this reduction has been studied in B. R. buffer in the pH range 3.13 - 11.0. The Bupropion hydrochloride is best reduced in slightly acidic medium. This behavior was attributed to the reduction of >C=O group present in the drug. The effect of concentration and temperature on half wave potential has also been investigated. The reduction of drug was found to be irreversible and diffusion controlled, hence kinetic parameters (K0fh, αn) are evaluated using Meites Israel and Gaur Bharagav,s method. Further, with increase in temperature the values of K0fh also increase, showing that irreversibility of the system decreases on increasing the temperature.
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spelling The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion HydrochlorideDC polarographyreductionantidepressant drugBupropion hydrochlorideThe electroreduction of the antidepressant drug Bupropion hydrochloride has been studied in aqueous media at dme. Single well defined wave was obtained in different supporting electrolytes, like, KNO3, ammonium citrate buffer, acetate buffer, B. R. buffer, etc. The effect of pH on this reduction has been studied in B. R. buffer in the pH range 3.13 - 11.0. The Bupropion hydrochloride is best reduced in slightly acidic medium. This behavior was attributed to the reduction of >C=O group present in the drug. The effect of concentration and temperature on half wave potential has also been investigated. The reduction of drug was found to be irreversible and diffusion controlled, hence kinetic parameters (K0fh, αn) are evaluated using Meites Israel and Gaur Bharagav,s method. Further, with increase in temperature the values of K0fh also increase, showing that irreversibility of the system decreases on increasing the temperature.Sociedade Portuguesa de Electroquímica2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042010000200002Portugaliae Electrochimica Acta v.28 n.2 2010reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042010000200002Samota,ShardaGarg,AshishPandey,Rajayashreeinfo:eu-repo/semantics/openAccess2024-02-06T17:07:04Zoai:scielo:S0872-19042010000200002Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:08.655347Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion Hydrochloride
title The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion Hydrochloride
spellingShingle The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion Hydrochloride
Samota,Sharda
DC polarography
reduction
antidepressant drug
Bupropion hydrochloride
title_short The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion Hydrochloride
title_full The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion Hydrochloride
title_fullStr The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion Hydrochloride
title_full_unstemmed The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion Hydrochloride
title_sort The Polarographic Reduction and Electrode Kinetics of Anti-depressant Drug Bupropion Hydrochloride
author Samota,Sharda
author_facet Samota,Sharda
Garg,Ashish
Pandey,Rajayashree
author_role author
author2 Garg,Ashish
Pandey,Rajayashree
author2_role author
author
dc.contributor.author.fl_str_mv Samota,Sharda
Garg,Ashish
Pandey,Rajayashree
dc.subject.por.fl_str_mv DC polarography
reduction
antidepressant drug
Bupropion hydrochloride
topic DC polarography
reduction
antidepressant drug
Bupropion hydrochloride
description The electroreduction of the antidepressant drug Bupropion hydrochloride has been studied in aqueous media at dme. Single well defined wave was obtained in different supporting electrolytes, like, KNO3, ammonium citrate buffer, acetate buffer, B. R. buffer, etc. The effect of pH on this reduction has been studied in B. R. buffer in the pH range 3.13 - 11.0. The Bupropion hydrochloride is best reduced in slightly acidic medium. This behavior was attributed to the reduction of >C=O group present in the drug. The effect of concentration and temperature on half wave potential has also been investigated. The reduction of drug was found to be irreversible and diffusion controlled, hence kinetic parameters (K0fh, αn) are evaluated using Meites Israel and Gaur Bharagav,s method. Further, with increase in temperature the values of K0fh also increase, showing that irreversibility of the system decreases on increasing the temperature.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042010000200002
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042010000200002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042010000200002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
dc.source.none.fl_str_mv Portugaliae Electrochimica Acta v.28 n.2 2010
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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