PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/69642 |
Resumo: | "Available online 6 January 2021" |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritisRheumatoid arthritisInflamed jointPAMAM dendrimerChondroitin sulphateAnti-TNF αPolyclonal antibodyScience & Technology"Available online 6 January 2021"Rheumatoid arthritis is a chronic autoimmune disease characterised by joint synovial inflammation, along with cartilage and bone tissue destruction. Dendrimers can offer new opportunities as drug delivery systems of molecules of interest. Herein we aimed to develop poly(amidoamine) dendrimers (PAMAM), functionalised with chondroitin sulphate (CS), lined with anti-TNF α antibodies (Abs) to provide anti-inflammatory properties. Physicochemical characterisation demonstrated that anti-TNFα Abs-CS/PAMAM dendrimer NPs were successfully produced. The in vitro studies revealed that CS/PAMAM dendrimer NPs did not affect the ATDC5 and THP-1 cell lines' metabolic activity and proliferation, presenting good cytocompatibility and hemocompatibility. Moreover, anti-TNFα Abs-CS/PAMAM dendrimer NPs showed suitable TNF α capture capacity, making them appealing for new immunotherapies in RA patients.The authors thank the financial support under the Norte2020 project (“NORTE-08-5369-FSE-000044”) and BD/137726/2018/J6 21340zkMF. The FCT distinction attributed to J. M. O. under the Investigator FCT program (number IF/01285/2015) is also greatly acknowledged. C. G. also wished to acknowledge FCT for supporting her research (No. SFRH/BPD/94277/2013). RS and AG-F thank Xunta de Galicia (Grupo de Referencia Competitiva, ED431C 2016041) and Centro de Investigaciones Biom ́edicas (CINBIO), Vigo, Spain, for sup-porting their research.ElsevierUniversidade do MinhoOliveira, Isabel Maria Lopes MatosGonçalves, CristianaOliveira, Maria Eduarda Moreira Pinheiro SantosSimón-Váz, Rosanada Silva Morais, AlainGonzález-Fernández, ÁfricaReis, R. L.Oliveira, J. M.2021-012021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/69642engOliveira I. M., Cristiana G., Oliveira E. P., Rosana S. - V., Silva A. M., África G. - F., Reis R. L., Oliveira J. M. PAMAM Dendrimers Functionalised with an Anti-TNF α Antibody and Chondroitin Sulphate for Treatment of Rheumatoid Arthritis, Materials Science and Engineering: C, pp. 111845, doi:10.1016/j.msec.2020.111845, 20210928-493110.1016/j.msec.2020.11184533579481https://www.sciencedirect.com/science/article/pii/S0928493120337644?via%3Dihubinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:24ZPortal AgregadorONG |
| dc.title.none.fl_str_mv |
PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis |
| title |
PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis |
| spellingShingle |
PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis Oliveira, Isabel Maria Lopes Matos Rheumatoid arthritis Inflamed joint PAMAM dendrimer Chondroitin sulphate Anti-TNF α Polyclonal antibody Science & Technology |
| title_short |
PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis |
| title_full |
PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis |
| title_fullStr |
PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis |
| title_full_unstemmed |
PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis |
| title_sort |
PAMAM dendrimers functionalised with an anti-TNF α antibody and chondroitin sulphate for treatment of rheumatoid arthritis |
| author |
Oliveira, Isabel Maria Lopes Matos |
| author_facet |
Oliveira, Isabel Maria Lopes Matos Gonçalves, Cristiana Oliveira, Maria Eduarda Moreira Pinheiro Santos Simón-Váz, Rosana da Silva Morais, Alain González-Fernández, África Reis, R. L. Oliveira, J. M. |
| author_role |
author |
| author2 |
Gonçalves, Cristiana Oliveira, Maria Eduarda Moreira Pinheiro Santos Simón-Váz, Rosana da Silva Morais, Alain González-Fernández, África Reis, R. L. Oliveira, J. M. |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Oliveira, Isabel Maria Lopes Matos Gonçalves, Cristiana Oliveira, Maria Eduarda Moreira Pinheiro Santos Simón-Váz, Rosana da Silva Morais, Alain González-Fernández, África Reis, R. L. Oliveira, J. M. |
| dc.subject.por.fl_str_mv |
Rheumatoid arthritis Inflamed joint PAMAM dendrimer Chondroitin sulphate Anti-TNF α Polyclonal antibody Science & Technology |
| topic |
Rheumatoid arthritis Inflamed joint PAMAM dendrimer Chondroitin sulphate Anti-TNF α Polyclonal antibody Science & Technology |
| description |
"Available online 6 January 2021" |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-01 2021-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/69642 |
| url |
http://hdl.handle.net/1822/69642 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Oliveira I. M., Cristiana G., Oliveira E. P., Rosana S. - V., Silva A. M., África G. - F., Reis R. L., Oliveira J. M. PAMAM Dendrimers Functionalised with an Anti-TNF α Antibody and Chondroitin Sulphate for Treatment of Rheumatoid Arthritis, Materials Science and Engineering: C, pp. 111845, doi:10.1016/j.msec.2020.111845, 2021 0928-4931 10.1016/j.msec.2020.111845 33579481 https://www.sciencedirect.com/science/article/pii/S0928493120337644?via%3Dihub |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303798166847488 |