Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal

Detalhes bibliográficos
Autor(a) principal: Linhares, Maria Inês
Data de Publicação: 2021
Outros Autores: Brett, Ana, Correia, Lurdes, Pereira, Henriqueta, Correia, Cristina, Oleastro, Mónica, de Sousa, Rita, Rodrigues, Fernanda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032
Resumo: Introduction: Human parechovirus type 3 has been recognized as a cause of pediatric infection, occasionally associated with serious illness, including sepsis and meningitis, particularly among young infants. The aim of this study is to report the first known human parechovirus type 3 outbreak in Portugal.Material and Methods: Descriptive study of an outbreak that occurred between the 8th June to the 12th August 2016. Laboratory diagnosis was made by reverse transcription - polymerase chain reaction in the cerebrospinal fluid and/or in stools. Genotyping was made by reverse transcription - polymerase chain reaction and sequencing in stool samples from infants and family members.Results: Human parechovirus type 3 infection was detected in seven infants, of which six were male. Median age was 23 days (5 - 52). One had seizures, with a magnetic resonance imaging scan showing white matter diffusion restriction. The mean duration of admission was 5.6 days (3 - 11), with favourable outcome in all. In three cases there were symptomatic close family members. Human parechovirus type 3 was identified in the stools of three mothers.Discussion: Even though human parechovirus type 3 infection has been well described in the presented age group, most Portuguese hospitals do not have this laboratory diagnosis. Our results are comparable to those obtained in other countries. Besides detection of the virus in the cerebrospinal fluid, there were no raised local or systemic inflammatory markers.Conclusion: This study reports the first known outbreak, in infants, of human parechovirus type 3 in Portugal. Although there is no specific treatment, this diagnosis can avoid unnecessary empirical antibiotic treatment and prolonged admissions.
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spelling Parechovirus Genotype 3 Outbreak Among Young Infants in PortugalSurto de Infeção em Portugal por Parechovirus Genótipo 3 em Pequenos LactentesCommunicable DiseasesEmergingInfantParechovirusPicornaviridae InfectionsPortugalDoenças Transmissíveis EmergentesInfecções por PicornaviridaeLactentesParechovirusPortugalIntroduction: Human parechovirus type 3 has been recognized as a cause of pediatric infection, occasionally associated with serious illness, including sepsis and meningitis, particularly among young infants. The aim of this study is to report the first known human parechovirus type 3 outbreak in Portugal.Material and Methods: Descriptive study of an outbreak that occurred between the 8th June to the 12th August 2016. Laboratory diagnosis was made by reverse transcription - polymerase chain reaction in the cerebrospinal fluid and/or in stools. Genotyping was made by reverse transcription - polymerase chain reaction and sequencing in stool samples from infants and family members.Results: Human parechovirus type 3 infection was detected in seven infants, of which six were male. Median age was 23 days (5 - 52). One had seizures, with a magnetic resonance imaging scan showing white matter diffusion restriction. The mean duration of admission was 5.6 days (3 - 11), with favourable outcome in all. In three cases there were symptomatic close family members. Human parechovirus type 3 was identified in the stools of three mothers.Discussion: Even though human parechovirus type 3 infection has been well described in the presented age group, most Portuguese hospitals do not have this laboratory diagnosis. Our results are comparable to those obtained in other countries. Besides detection of the virus in the cerebrospinal fluid, there were no raised local or systemic inflammatory markers.Conclusion: This study reports the first known outbreak, in infants, of human parechovirus type 3 in Portugal. Although there is no specific treatment, this diagnosis can avoid unnecessary empirical antibiotic treatment and prolonged admissions.Introdução: O parechovirus humano tipo 3 tem sido reconhecido como causa de infeção em idade pediátrica, ocasionalmente associado a doença grave, incluindo sépsis e meningite, particularmente em pequenos lactentes. Foi objectivo deste estudo descrever o primeiro surto conhecido de infeção por parechovirus humano tipo 3 em Portugal.Material e Métodos: Estudo descritivo de um surto ocorrido entre 8 de junho a 12 de agosto de 2016. O diagnóstico laboratorial foi realizado por transcriptase reversa - reação em cadeia da polimerase no líquido cefalorraquidiano e/ou nas fezes. A genotipagem foi efetuada no Instituto Nacional de Saúde Doutor Ricardo Jorge, por transcriptase reversa - reação em cadeia da polimerase e sequenciação, em amostras de fezes dos lactentes e seus familiares.Resultados: Foi detetada infeção por parechovirus humano tipo 3 em sete lactentes, seis dos quais do sexo masculino, mediana de idade de 23 dias (5 - 52). Uma lactente apresentou convulsões, com múltiplas lesões da substância branca na ressonância magnética nuclear. A duração média de internamento foi de 5,6 dias (3 - 11), com evolução favorável em todos. Em três casos havia familiares próximos sintomáticos. Em três mães foi identificado parechovirus humano tipo 3 nas fezes.Discussão: Embora a infeção por parechovirus humano tipo 3 esteja bem descrita neste grupo etário, a maior parte dos hospitais portugueses não dispõe deste diagnóstico laboratorial. Os resultados obtidos foram semelhantes aos verificados noutros países. Apesar da deteção do vírus no líquido cefalorraquidiano, destaca-se a ausência de resposta inflamatória local ou sistémica.Conclusão: Este estudo reporta o primeiro surto conhecido de infeção por parechovirus humano tipo 3 ocorrido em Portugal em pequenos lactentes. Apesar de não existir tratamento específico, este diagnóstico poderá evitar poderá evitar antibioterapia e internamentos prolongados.Ordem dos Médicos2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032oai:ojs.www.actamedicaportuguesa.com:article/15032Acta Médica Portuguesa; Vol. 34 No. 10 (2021): Outubro; 664-668Acta Médica Portuguesa; Vol. 34 N.º 10 (2021): Outubro; 664-6681646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/6289https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/12976https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/12977https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/13101https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/13326Direitos de Autor (c) 2021 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessLinhares, Maria InêsBrett, AnaCorreia, LurdesPereira, HenriquetaCorreia, CristinaOleastro, Mónicade Sousa, RitaRodrigues, Fernanda2022-12-20T11:07:24Zoai:ojs.www.actamedicaportuguesa.com:article/15032Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:33.999859Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal
Surto de Infeção em Portugal por Parechovirus Genótipo 3 em Pequenos Lactentes
title Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal
spellingShingle Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal
Linhares, Maria Inês
Communicable Diseases
Emerging
Infant
Parechovirus
Picornaviridae Infections
Portugal
Doenças Transmissíveis Emergentes
Infecções por Picornaviridae
Lactentes
Parechovirus
Portugal
title_short Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal
title_full Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal
title_fullStr Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal
title_full_unstemmed Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal
title_sort Parechovirus Genotype 3 Outbreak Among Young Infants in Portugal
author Linhares, Maria Inês
author_facet Linhares, Maria Inês
Brett, Ana
Correia, Lurdes
Pereira, Henriqueta
Correia, Cristina
Oleastro, Mónica
de Sousa, Rita
Rodrigues, Fernanda
author_role author
author2 Brett, Ana
Correia, Lurdes
Pereira, Henriqueta
Correia, Cristina
Oleastro, Mónica
de Sousa, Rita
Rodrigues, Fernanda
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Linhares, Maria Inês
Brett, Ana
Correia, Lurdes
Pereira, Henriqueta
Correia, Cristina
Oleastro, Mónica
de Sousa, Rita
Rodrigues, Fernanda
dc.subject.por.fl_str_mv Communicable Diseases
Emerging
Infant
Parechovirus
Picornaviridae Infections
Portugal
Doenças Transmissíveis Emergentes
Infecções por Picornaviridae
Lactentes
Parechovirus
Portugal
topic Communicable Diseases
Emerging
Infant
Parechovirus
Picornaviridae Infections
Portugal
Doenças Transmissíveis Emergentes
Infecções por Picornaviridae
Lactentes
Parechovirus
Portugal
description Introduction: Human parechovirus type 3 has been recognized as a cause of pediatric infection, occasionally associated with serious illness, including sepsis and meningitis, particularly among young infants. The aim of this study is to report the first known human parechovirus type 3 outbreak in Portugal.Material and Methods: Descriptive study of an outbreak that occurred between the 8th June to the 12th August 2016. Laboratory diagnosis was made by reverse transcription - polymerase chain reaction in the cerebrospinal fluid and/or in stools. Genotyping was made by reverse transcription - polymerase chain reaction and sequencing in stool samples from infants and family members.Results: Human parechovirus type 3 infection was detected in seven infants, of which six were male. Median age was 23 days (5 - 52). One had seizures, with a magnetic resonance imaging scan showing white matter diffusion restriction. The mean duration of admission was 5.6 days (3 - 11), with favourable outcome in all. In three cases there were symptomatic close family members. Human parechovirus type 3 was identified in the stools of three mothers.Discussion: Even though human parechovirus type 3 infection has been well described in the presented age group, most Portuguese hospitals do not have this laboratory diagnosis. Our results are comparable to those obtained in other countries. Besides detection of the virus in the cerebrospinal fluid, there were no raised local or systemic inflammatory markers.Conclusion: This study reports the first known outbreak, in infants, of human parechovirus type 3 in Portugal. Although there is no specific treatment, this diagnosis can avoid unnecessary empirical antibiotic treatment and prolonged admissions.
publishDate 2021
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dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/6289
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/12976
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/12977
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/13101
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15032/13326
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2021 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 34 No. 10 (2021): Outubro; 664-668
Acta Médica Portuguesa; Vol. 34 N.º 10 (2021): Outubro; 664-668
1646-0758
0870-399X
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