Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15043 |
Resumo: | Texto completo: acesso restrito. p. 564-571 |
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Drexler, Jan FelixGrywna, KlausLukashev, AlexanderAlmeida, Patrícia SilvaRibeiro, Tereza Cristina MedradoPetersen, NadineRibeiro Jr, Hugo da CostaBelalov, IlyaKümmerer, Beate MareikeDrexler, Jan FelixGrywna, KlausLukashev, AlexanderAlmeida, Patrícia SilvaRibeiro, Tereza Cristina MedradoPetersen, NadineRibeiro Jr, Hugo da CostaBelalov, IlyaKümmerer, Beate Mareike2014-06-02T13:18:08Z20110022-1317http://repositorio.ufba.br/ri/handle/ri/15043v. 92, n. 3Texto completo: acesso restrito. p. 564-571Due to high genome plasticity, the evolutionary fate and geographical history of picornaviruses is hard to follow. Here, we determined the complete coding sequences of eight human parechoviruses (HPeV) of types 1, 5 and 6 directly from clinical samples from Brazil. The capsid genes of these strains were not remarkably different from European, North American and Japanese HPeV. Full genome analysis revealed frequent intertypic recombination in the non-structural genome region. In addition, evidence of recombination between viruses of the same type in the capsid-encoding genome region among HPeV1 and HPeV4 was obtained. Bayesian phylogenetic analysis indicated that strains without evidence of recombination with each other in any genome region were separated by no more than 35 years of circulation. Interestingly, in the 3C gene, all Brazilian parechoviruses grouped together regardless of serotype. The most recent common ancestor of these strains dated back 108 years, suggesting long-term endemicity of this particular P3 genome lineage in South America. Our results support the idea that picornavirus replicative genes acquire capsid proteins introduced by new strains. Under certain epidemiological conditions, replicative genes may be maintained in circumscript geographical regions.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-03T15:54:23Z No. of bitstreams: 1 Jan Felix Drexler.pdf: 619275 bytes, checksum: 9783783897cc5f4ca2013d49be66c06c (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-02T13:18:08Z (GMT) No. of bitstreams: 1 Jan Felix Drexler.pdf: 619275 bytes, checksum: 9783783897cc5f4ca2013d49be66c06c (MD5)Made available in DSpace on 2014-06-02T13:18:08Z (GMT). No. of bitstreams: 1 Jan Felix Drexler.pdf: 619275 bytes, checksum: 9783783897cc5f4ca2013d49be66c06c (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1099/vir.0.022525-0reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAPicornaviridae infectionsCapsid proteinsGenesFull genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid regionJournal of General Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15043/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALJan Felix Drexler.pdfJan Felix Drexler.pdfapplication/pdf619275https://repositorio.ufba.br/bitstream/ri/15043/1/Jan%20Felix%20Drexler.pdf9783783897cc5f4ca2013d49be66c06cMD51TEXTJan Felix Drexler.pdf.txtJan Felix Drexler.pdf.txtExtracted texttext/plain37456https://repositorio.ufba.br/bitstream/ri/15043/3/Jan%20Felix%20Drexler.pdf.txt9fd9106a1bb49272f66839721073b6c8MD53ri/150432022-07-05 14:04:17.898oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:17Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of General Virology |
| title |
Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region |
| spellingShingle |
Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region Drexler, Jan Felix Picornaviridae infections Capsid proteins Genes |
| title_short |
Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region |
| title_full |
Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region |
| title_fullStr |
Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region |
| title_full_unstemmed |
Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region |
| title_sort |
Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region |
| author |
Drexler, Jan Felix |
| author_facet |
Drexler, Jan Felix Grywna, Klaus Lukashev, Alexander Almeida, Patrícia Silva Ribeiro, Tereza Cristina Medrado Petersen, Nadine Ribeiro Jr, Hugo da Costa Belalov, Ilya Kümmerer, Beate Mareike |
| author_role |
author |
| author2 |
Grywna, Klaus Lukashev, Alexander Almeida, Patrícia Silva Ribeiro, Tereza Cristina Medrado Petersen, Nadine Ribeiro Jr, Hugo da Costa Belalov, Ilya Kümmerer, Beate Mareike |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Drexler, Jan Felix Grywna, Klaus Lukashev, Alexander Almeida, Patrícia Silva Ribeiro, Tereza Cristina Medrado Petersen, Nadine Ribeiro Jr, Hugo da Costa Belalov, Ilya Kümmerer, Beate Mareike Drexler, Jan Felix Grywna, Klaus Lukashev, Alexander Almeida, Patrícia Silva Ribeiro, Tereza Cristina Medrado Petersen, Nadine Ribeiro Jr, Hugo da Costa Belalov, Ilya Kümmerer, Beate Mareike |
| dc.subject.por.fl_str_mv |
Picornaviridae infections Capsid proteins Genes |
| topic |
Picornaviridae infections Capsid proteins Genes |
| description |
Texto completo: acesso restrito. p. 564-571 |
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2011 |
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2011 |
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2014-06-02T13:18:08Z |
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info:eu-repo/semantics/publishedVersion |
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0022-1317 |
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v. 92, n. 3 |
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0022-1317 v. 92, n. 3 |
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http://repositorio.ufba.br/ri/handle/ri/15043 |
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