Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/11420 |
Resumo: | High-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries that exhibit anti-neuroinflammatory properties in the context of obesity. Here, we demonstrate that the blackberry anthocyanin-rich extract (BE) can modulate gut microbiota composition and counteract some of the features of HF-diet induced dysbiosis. In addition, we show that the modifications in gut microbial environment are partially linked with the anti-neuroinflammatory properties of BE. Through fecal metabolome analysis, we unravel the mechanism by which BE participates in the bilateral communication between the gut and the brain. BE alters host tryptophan metabolism, increasing the production of the neuroprotective metabolite kynurenic acid. These findings strongly suggest that dietary manipulation of the gut microbiota with anthocyanins can attenuate the neurologic complications of obesity, thus expanding the classification of psychobiotics to anthocyanins. |
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Gut microbiota modulation accounts for the neuroprotective properties of anthocyaninsHigh-fat dietIntestinal microbiotaInduced obesityBrainNeuroinflammationInflammationMicrogliaBacteriaPsychobioticsDysbiosisHigh-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries that exhibit anti-neuroinflammatory properties in the context of obesity. Here, we demonstrate that the blackberry anthocyanin-rich extract (BE) can modulate gut microbiota composition and counteract some of the features of HF-diet induced dysbiosis. In addition, we show that the modifications in gut microbial environment are partially linked with the anti-neuroinflammatory properties of BE. Through fecal metabolome analysis, we unravel the mechanism by which BE participates in the bilateral communication between the gut and the brain. BE alters host tryptophan metabolism, increasing the production of the neuroprotective metabolite kynurenic acid. These findings strongly suggest that dietary manipulation of the gut microbiota with anthocyanins can attenuate the neurologic complications of obesity, thus expanding the classification of psychobiotics to anthocyanins.FEDER - Programa Operacional Competitividade e Internacionalizacao - COMPETE2020 [POCI-01-0145-ERDF-007746]; National Funds through FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS, RD Unit [UID/IC/4255/2013]; [SFRH/BD/93073/2013]; [SFRH/BPD/86173/2012]; [UID/QUI/50006/2013]Nature Publishing GroupSapientiaMarques, ClaudiaFernandes, IvaMeireles, ManuelaFaria, AnaSpencer, Jeremy P. E.Mateus, NunoCalhau, Conceicao2018-12-07T14:53:14Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11420eng2045-232210.1038/s41598-018-29744-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:23:14Zoai:sapientia.ualg.pt:10400.1/11420Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:55.954265Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins |
title |
Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins |
spellingShingle |
Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins Marques, Claudia High-fat diet Intestinal microbiota Induced obesity Brain Neuroinflammation Inflammation Microglia Bacteria Psychobiotics Dysbiosis |
title_short |
Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins |
title_full |
Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins |
title_fullStr |
Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins |
title_full_unstemmed |
Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins |
title_sort |
Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins |
author |
Marques, Claudia |
author_facet |
Marques, Claudia Fernandes, Iva Meireles, Manuela Faria, Ana Spencer, Jeremy P. E. Mateus, Nuno Calhau, Conceicao |
author_role |
author |
author2 |
Fernandes, Iva Meireles, Manuela Faria, Ana Spencer, Jeremy P. E. Mateus, Nuno Calhau, Conceicao |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Marques, Claudia Fernandes, Iva Meireles, Manuela Faria, Ana Spencer, Jeremy P. E. Mateus, Nuno Calhau, Conceicao |
dc.subject.por.fl_str_mv |
High-fat diet Intestinal microbiota Induced obesity Brain Neuroinflammation Inflammation Microglia Bacteria Psychobiotics Dysbiosis |
topic |
High-fat diet Intestinal microbiota Induced obesity Brain Neuroinflammation Inflammation Microglia Bacteria Psychobiotics Dysbiosis |
description |
High-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries that exhibit anti-neuroinflammatory properties in the context of obesity. Here, we demonstrate that the blackberry anthocyanin-rich extract (BE) can modulate gut microbiota composition and counteract some of the features of HF-diet induced dysbiosis. In addition, we show that the modifications in gut microbial environment are partially linked with the anti-neuroinflammatory properties of BE. Through fecal metabolome analysis, we unravel the mechanism by which BE participates in the bilateral communication between the gut and the brain. BE alters host tryptophan metabolism, increasing the production of the neuroprotective metabolite kynurenic acid. These findings strongly suggest that dietary manipulation of the gut microbiota with anthocyanins can attenuate the neurologic complications of obesity, thus expanding the classification of psychobiotics to anthocyanins. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-07T14:53:14Z 2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/11420 |
url |
http://hdl.handle.net/10400.1/11420 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2045-2322 10.1038/s41598-018-29744-5 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799133263463186432 |