Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins

Detalhes bibliográficos
Autor(a) principal: Marques, Claudia
Data de Publicação: 2018
Outros Autores: Fernandes, Iva, Meireles, Manuela, Faria, Ana, Spencer, Jeremy P. E., Mateus, Nuno, Calhau, Conceicao
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/11420
Resumo: High-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries that exhibit anti-neuroinflammatory properties in the context of obesity. Here, we demonstrate that the blackberry anthocyanin-rich extract (BE) can modulate gut microbiota composition and counteract some of the features of HF-diet induced dysbiosis. In addition, we show that the modifications in gut microbial environment are partially linked with the anti-neuroinflammatory properties of BE. Through fecal metabolome analysis, we unravel the mechanism by which BE participates in the bilateral communication between the gut and the brain. BE alters host tryptophan metabolism, increasing the production of the neuroprotective metabolite kynurenic acid. These findings strongly suggest that dietary manipulation of the gut microbiota with anthocyanins can attenuate the neurologic complications of obesity, thus expanding the classification of psychobiotics to anthocyanins.
id RCAP_ff0dad7b3cfaa7f4b34847c822a3edd0
oai_identifier_str oai:sapientia.ualg.pt:10400.1/11420
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Gut microbiota modulation accounts for the neuroprotective properties of anthocyaninsHigh-fat dietIntestinal microbiotaInduced obesityBrainNeuroinflammationInflammationMicrogliaBacteriaPsychobioticsDysbiosisHigh-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries that exhibit anti-neuroinflammatory properties in the context of obesity. Here, we demonstrate that the blackberry anthocyanin-rich extract (BE) can modulate gut microbiota composition and counteract some of the features of HF-diet induced dysbiosis. In addition, we show that the modifications in gut microbial environment are partially linked with the anti-neuroinflammatory properties of BE. Through fecal metabolome analysis, we unravel the mechanism by which BE participates in the bilateral communication between the gut and the brain. BE alters host tryptophan metabolism, increasing the production of the neuroprotective metabolite kynurenic acid. These findings strongly suggest that dietary manipulation of the gut microbiota with anthocyanins can attenuate the neurologic complications of obesity, thus expanding the classification of psychobiotics to anthocyanins.FEDER - Programa Operacional Competitividade e Internacionalizacao - COMPETE2020 [POCI-01-0145-ERDF-007746]; National Funds through FCT - Fundacao para a Ciencia e a Tecnologia within CINTESIS, RD Unit [UID/IC/4255/2013]; [SFRH/BD/93073/2013]; [SFRH/BPD/86173/2012]; [UID/QUI/50006/2013]Nature Publishing GroupSapientiaMarques, ClaudiaFernandes, IvaMeireles, ManuelaFaria, AnaSpencer, Jeremy P. E.Mateus, NunoCalhau, Conceicao2018-12-07T14:53:14Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11420eng2045-232210.1038/s41598-018-29744-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:23:14Zoai:sapientia.ualg.pt:10400.1/11420Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:02:55.954265Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
spellingShingle Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
Marques, Claudia
High-fat diet
Intestinal microbiota
Induced obesity
Brain
Neuroinflammation
Inflammation
Microglia
Bacteria
Psychobiotics
Dysbiosis
title_short Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title_full Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title_fullStr Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title_full_unstemmed Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
title_sort Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins
author Marques, Claudia
author_facet Marques, Claudia
Fernandes, Iva
Meireles, Manuela
Faria, Ana
Spencer, Jeremy P. E.
Mateus, Nuno
Calhau, Conceicao
author_role author
author2 Fernandes, Iva
Meireles, Manuela
Faria, Ana
Spencer, Jeremy P. E.
Mateus, Nuno
Calhau, Conceicao
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Marques, Claudia
Fernandes, Iva
Meireles, Manuela
Faria, Ana
Spencer, Jeremy P. E.
Mateus, Nuno
Calhau, Conceicao
dc.subject.por.fl_str_mv High-fat diet
Intestinal microbiota
Induced obesity
Brain
Neuroinflammation
Inflammation
Microglia
Bacteria
Psychobiotics
Dysbiosis
topic High-fat diet
Intestinal microbiota
Induced obesity
Brain
Neuroinflammation
Inflammation
Microglia
Bacteria
Psychobiotics
Dysbiosis
description High-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries that exhibit anti-neuroinflammatory properties in the context of obesity. Here, we demonstrate that the blackberry anthocyanin-rich extract (BE) can modulate gut microbiota composition and counteract some of the features of HF-diet induced dysbiosis. In addition, we show that the modifications in gut microbial environment are partially linked with the anti-neuroinflammatory properties of BE. Through fecal metabolome analysis, we unravel the mechanism by which BE participates in the bilateral communication between the gut and the brain. BE alters host tryptophan metabolism, increasing the production of the neuroprotective metabolite kynurenic acid. These findings strongly suggest that dietary manipulation of the gut microbiota with anthocyanins can attenuate the neurologic complications of obesity, thus expanding the classification of psychobiotics to anthocyanins.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-07T14:53:14Z
2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/11420
url http://hdl.handle.net/10400.1/11420
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2045-2322
10.1038/s41598-018-29744-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133263463186432