Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/62089 |
Resumo: | Copyright © 2016 The Authors. This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
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Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter studyadolescentsantiretroviral therapychildrenHIV-1rilpivirineCopyright © 2016 The Authors. This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0To assess the safety and efficacy of rilpivirine in combination with emtricitabine and tenofovir (RPV/FTC/TDF) as a once-daily single-tablet regimen (STR) in HIV-1-infected children and adolescents we performed a multicenter case series study of HIV-1-infected patients. Inclusion criteria were initiation of therapy with RPV/FTC/TDF before the age of 18. Patients were divided into undetectable viral load (uVL) group, HIV-1 RNA < 20 copies/mL on stable combined antiretroviral therapy (cART), and detectable viral load (dVL) group, HIV-1 RNA ≥ 20 copies/mL at RPV/FTC/TDF initiation. Patients were monitored from the date of RPV/FTC/TDF initiation until June 30, 2015, RPV/FTC/TDF discontinuation or failure to follow-up. Seventeen patients (8 in uVL and 9 in dVL group) with age between 11.6 and 17.6 were included. Reasons for switching were toxicity (n = 4) and simplification (n = 4) in uVL; viral failure (n = 8) and cART initiation (n = 1) in the dVL group. After a median follow-up of 90 (uVL) and 40 weeks (dVL), 7/8 (86%) patients maintained and 8/9 (89%) achieved and maintained HIV-1 suppression. Median CD4 count increased from 542 to 780/μL (uVL, P = 0.069) and 480 to 830/μL (dVL, P = 0.051). Five patients (2 in uVL and 3 in dVL) improved their immunological status from moderate to no immunosuppression. Serum lipid profiles improved in both groups; cholesterol dropped significantly in the dVL group (P = 0.008). Grade 1 laboratory adverse events (AEs) were observed in 3 patients. No clinical AEs occurred. Adherence was complete in 9 patients (5 in uVL and 4 in dVL); 1 adolescent interrupted treatment. Once-daily STR with RPV/FTC/TDF may be a safe and effective choice in selected HIV-1-infected adolescents and children.Financial support was provided by the Instituto de Salud Carlos III through the Red Temática de Investigación Cooperativa en Sida (ISCIII-RETIC RD06/006; RD12/0017/0035, and RD12/0017/0037) and FIPSE (grant number: 36-0910-10). This work has been also supported by grants from Instituto de Salud Carlos III (Ref. MPY 1039/14 to VB). CP is supported by the Portuguese Fundação para a Ciência e Tecnologia (FCT) (grant number SFRH/BPD/77448/2011, part of the EDCTP2 program supported by the European Union). VB is supported by the Miguel Servet program run by the Fondo de Investigación Sanitaria (ISCIII) (grant number CP13/00098).Wolters Kluwer HealthRepositório da Universidade de LisboaFalcon-Neyra, LolaPalladino, ClaudiaGomez, María Luisa NavarroSoler-Palacin, PereGonzalez-Tome, María IsabelDe Ory, Santiago J.Frick, Marie AntoinetteFortuny, ClàudiaNoguera-Julian, AntoniMoreno, Elena BermúdezSantos, Juan LuisOlbrich, PeterLópez-Cortés, Luis F.Briz, VerónicaNeth, Olaf2024-01-24T19:56:51Z20162023-02-09T15:06:56Z2016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/62089engFalcon-Neyra L, Palladino C, Navarro Gómez ML, Soler-Palacín P, González-Tomé MI, De Ory SJ, et al. Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients: A multicenter study. Medicine [Internet]. junho de 2016;95(24):e3842. Disponível em: https://journals.lww.com/00005792-201606140-00021cv-prod-118552710.1097/MD.00000000000038422-s2.0-84976351380info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-29T01:19:33Zoai:repositorio.ul.pt:10451/62089Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:58:28.811033Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study |
| title |
Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study |
| spellingShingle |
Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study Falcon-Neyra, Lola adolescents antiretroviral therapy children HIV-1 rilpivirine |
| title_short |
Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study |
| title_full |
Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study |
| title_fullStr |
Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study |
| title_full_unstemmed |
Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study |
| title_sort |
Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study |
| author |
Falcon-Neyra, Lola |
| author_facet |
Falcon-Neyra, Lola Palladino, Claudia Gomez, María Luisa Navarro Soler-Palacin, Pere Gonzalez-Tome, María Isabel De Ory, Santiago J. Frick, Marie Antoinette Fortuny, Clàudia Noguera-Julian, Antoni Moreno, Elena Bermúdez Santos, Juan Luis Olbrich, Peter López-Cortés, Luis F. Briz, Verónica Neth, Olaf |
| author_role |
author |
| author2 |
Palladino, Claudia Gomez, María Luisa Navarro Soler-Palacin, Pere Gonzalez-Tome, María Isabel De Ory, Santiago J. Frick, Marie Antoinette Fortuny, Clàudia Noguera-Julian, Antoni Moreno, Elena Bermúdez Santos, Juan Luis Olbrich, Peter López-Cortés, Luis F. Briz, Verónica Neth, Olaf |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Falcon-Neyra, Lola Palladino, Claudia Gomez, María Luisa Navarro Soler-Palacin, Pere Gonzalez-Tome, María Isabel De Ory, Santiago J. Frick, Marie Antoinette Fortuny, Clàudia Noguera-Julian, Antoni Moreno, Elena Bermúdez Santos, Juan Luis Olbrich, Peter López-Cortés, Luis F. Briz, Verónica Neth, Olaf |
| dc.subject.por.fl_str_mv |
adolescents antiretroviral therapy children HIV-1 rilpivirine |
| topic |
adolescents antiretroviral therapy children HIV-1 rilpivirine |
| description |
Copyright © 2016 The Authors. This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2016-01-01T00:00:00Z 2023-02-09T15:06:56Z 2024-01-24T19:56:51Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/62089 |
| url |
http://hdl.handle.net/10451/62089 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Falcon-Neyra L, Palladino C, Navarro Gómez ML, Soler-Palacín P, González-Tomé MI, De Ory SJ, et al. Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients: A multicenter study. Medicine [Internet]. junho de 2016;95(24):e3842. Disponível em: https://journals.lww.com/00005792-201606140-00021 cv-prod-1185527 10.1097/MD.0000000000003842 2-s2.0-84976351380 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Wolters Kluwer Health |
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Wolters Kluwer Health |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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