Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol

Detalhes bibliográficos
Autor(a) principal: Cardoso de Lima, Mário Flávio
Data de Publicação: 2022
Outros Autores: Fraga Lopes, Marina Guedes, Justo Neto, Wellington Henrique, de Souza, Cláudio Teodoro
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Revista Ciências em Saúde
DOI: 10.21876/rcshci.v12i4.1329
Texto Completo: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329
Resumo: Objective: This study aims to evaluate the effects of omega-3-rich fish oil supplementation with or without physical activity on anti-inflammatory and insulin resistance parameters in obese and type 2 diabetic individuals. Methods: Randomized, double-blind intervention study of omega-3. Adults with obesity and type 2 diabetes mellitus on exclusive use of metformin as a drug to control blood glucose will be included. The Protocol will be based on clinical and nutritional follow-up (supplementation with omega-3) and remote physical activity for eight weeks. Individuals selected for the study will be randomly assigned to one of the following groups: i) omega-3; ii) omega-3 + physical activity; iii) physical activity + placebo; iv) placebo. To analyze the results, biochemical parameters (fasting glucose and insulin, glycosylated hemoglobin, liver enzymes, urea, creatinine, total cholesterol and fractions, triglycerides, CRP, and ferritin) and inflammatory parameters (TNF alpha, IL-1 beta, IL- 6 and IL-10). At the end of the study, it is expected that the intervention associated with omega-3 in the physical activity protocol will promote a reduction in parameters related to insulin resistance, levels of inflammatory cytokines, and anthropometric parameters.
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spelling Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocolEfeitos da suplementação de ômega-3 associado à atividade física em pacientes obesos portadores de diabetes mellitus do tipo 2: protocolo de estudo.Diabetes Mellitus Type 2ExerciseFatty Acids Omega-3ObesityObesidadeDiabetes Mellitus Tipo 2Ácidos Graxos Ômega-3Exercício FísicoObjective: This study aims to evaluate the effects of omega-3-rich fish oil supplementation with or without physical activity on anti-inflammatory and insulin resistance parameters in obese and type 2 diabetic individuals. Methods: Randomized, double-blind intervention study of omega-3. Adults with obesity and type 2 diabetes mellitus on exclusive use of metformin as a drug to control blood glucose will be included. The Protocol will be based on clinical and nutritional follow-up (supplementation with omega-3) and remote physical activity for eight weeks. Individuals selected for the study will be randomly assigned to one of the following groups: i) omega-3; ii) omega-3 + physical activity; iii) physical activity + placebo; iv) placebo. To analyze the results, biochemical parameters (fasting glucose and insulin, glycosylated hemoglobin, liver enzymes, urea, creatinine, total cholesterol and fractions, triglycerides, CRP, and ferritin) and inflammatory parameters (TNF alpha, IL-1 beta, IL- 6 and IL-10). At the end of the study, it is expected that the intervention associated with omega-3 in the physical activity protocol will promote a reduction in parameters related to insulin resistance, levels of inflammatory cytokines, and anthropometric parameters.Objetivo: O objetivo deste estudo será avaliar os efeitos de uma suplementação com óleo de peixe rico em ômega-3 associada ou não à atividade física sobre parâmetros anti-inflamatórios e de resistência à insulina em indivíduos obesos e diabéticos tipo 2. Métodos: Estudo randomizado, duplamente cegado para intervenção de ômega-3. Serão incluídos indivíduos adultos com obesidade, portadores de diabetes mellitus tipo 2 em uso exclusivo de metformina, como medicamento para controle da glicemia. O Protocolo será baseado em acompanhamento clínico, nutricional (suplementação com ômega-3) e atividade física remota por período de oito semanas. Os indivíduos selecionados para o estudo serão aleatoriamente encaminhados para um dos grupos: i) ômega-3; ii) ômega-3 + atividade física; iii) atividade física + placebo; iv) placebo. Para a análise dos resultados serão avaliados parâmetros bioquímicos (glicemia e insulina de jejum, hemoglobina glicosilada, enzimas hepáticas, ureia, creatinina, colesterol total e frações, triglicerídeos, PCR e ferritina) e inflamatórios (TNF alfa, IL-1 beta, IL-6 e IL-10). Ao final do estudo, espera-se que a intervenção associada de ômega-3 ao protocolo de atividade física promova redução de parâmetros relacionados à resistência insulínica, aos níveis de citocinas inflamatórias e aos parâmetros antropométricos.AISI/HCI2022-12-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos parestextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/132910.21876/rcshci.v12i4.1329Revista Ciências em Saúde; v. 12 n. 4 (2022): Outubro a Dezembro de 2022; 28-34Health Sciences Journal; Vol 12 No 4 (2022): October to December 2022; 28-342236-378510.21876/rcshci.v12i4reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIengporhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329/846https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329/847Copyright (c) 2022 Revista Ciências em Saúdehttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessCardoso de Lima, Mário Flávio Fraga Lopes, Marina GuedesJusto Neto, Wellington Henrique de Souza, Cláudio Teodoro2022-12-19T02:15:24Zoai:ojs.portalrcs.hcitajuba.org.br:article/1329Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2022-12-19T02:15:24Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse
dc.title.none.fl_str_mv Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
Efeitos da suplementação de ômega-3 associado à atividade física em pacientes obesos portadores de diabetes mellitus do tipo 2: protocolo de estudo.
title Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
spellingShingle Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
Cardoso de Lima, Mário Flávio
Diabetes Mellitus Type 2
Exercise
Fatty Acids Omega-3
Obesity
Obesidade
Diabetes Mellitus Tipo 2
Ácidos Graxos Ômega-3
Exercício Físico
Cardoso de Lima, Mário Flávio
Diabetes Mellitus Type 2
Exercise
Fatty Acids Omega-3
Obesity
Obesidade
Diabetes Mellitus Tipo 2
Ácidos Graxos Ômega-3
Exercício Físico
title_short Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
title_full Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
title_fullStr Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
title_full_unstemmed Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
title_sort Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
author Cardoso de Lima, Mário Flávio
author_facet Cardoso de Lima, Mário Flávio
Cardoso de Lima, Mário Flávio
Fraga Lopes, Marina Guedes
Justo Neto, Wellington Henrique
de Souza, Cláudio Teodoro
Fraga Lopes, Marina Guedes
Justo Neto, Wellington Henrique
de Souza, Cláudio Teodoro
author_role author
author2 Fraga Lopes, Marina Guedes
Justo Neto, Wellington Henrique
de Souza, Cláudio Teodoro
author2_role author
author
author
dc.contributor.author.fl_str_mv Cardoso de Lima, Mário Flávio
Fraga Lopes, Marina Guedes
Justo Neto, Wellington Henrique
de Souza, Cláudio Teodoro
dc.subject.por.fl_str_mv Diabetes Mellitus Type 2
Exercise
Fatty Acids Omega-3
Obesity
Obesidade
Diabetes Mellitus Tipo 2
Ácidos Graxos Ômega-3
Exercício Físico
topic Diabetes Mellitus Type 2
Exercise
Fatty Acids Omega-3
Obesity
Obesidade
Diabetes Mellitus Tipo 2
Ácidos Graxos Ômega-3
Exercício Físico
description Objective: This study aims to evaluate the effects of omega-3-rich fish oil supplementation with or without physical activity on anti-inflammatory and insulin resistance parameters in obese and type 2 diabetic individuals. Methods: Randomized, double-blind intervention study of omega-3. Adults with obesity and type 2 diabetes mellitus on exclusive use of metformin as a drug to control blood glucose will be included. The Protocol will be based on clinical and nutritional follow-up (supplementation with omega-3) and remote physical activity for eight weeks. Individuals selected for the study will be randomly assigned to one of the following groups: i) omega-3; ii) omega-3 + physical activity; iii) physical activity + placebo; iv) placebo. To analyze the results, biochemical parameters (fasting glucose and insulin, glycosylated hemoglobin, liver enzymes, urea, creatinine, total cholesterol and fractions, triglycerides, CRP, and ferritin) and inflammatory parameters (TNF alpha, IL-1 beta, IL- 6 and IL-10). At the end of the study, it is expected that the intervention associated with omega-3 in the physical activity protocol will promote a reduction in parameters related to insulin resistance, levels of inflammatory cytokines, and anthropometric parameters.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer reviewed
Avaliado pelos pares
texto
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329
10.21876/rcshci.v12i4.1329
url https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329
identifier_str_mv 10.21876/rcshci.v12i4.1329
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329/846
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329/847
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Ciências em Saúde
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Ciências em Saúde
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AISI/HCI
publisher.none.fl_str_mv AISI/HCI
dc.source.none.fl_str_mv Revista Ciências em Saúde; v. 12 n. 4 (2022): Outubro a Dezembro de 2022; 28-34
Health Sciences Journal; Vol 12 No 4 (2022): October to December 2022; 28-34
2236-3785
10.21876/rcshci.v12i4
reponame:Revista Ciências em Saúde
instname:Hospital de Clínicas de Itajubá
instacron:HCI
instname_str Hospital de Clínicas de Itajubá
instacron_str HCI
institution HCI
reponame_str Revista Ciências em Saúde
collection Revista Ciências em Saúde
repository.name.fl_str_mv Revista Ciências em Saúde - Hospital de Clínicas de Itajubá
repository.mail.fl_str_mv rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br
_version_ 1822179489053933568
dc.identifier.doi.none.fl_str_mv 10.21876/rcshci.v12i4.1329

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