Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol

Detalhes bibliográficos
Autor(a) principal: Cardoso de Lima, Mário Flávio
Data de Publicação: 2022
Outros Autores: Fraga Lopes, Marina Guedes, Justo Neto, Wellington Henrique, de Souza, Cláudio Teodoro
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Revista Ciências em Saúde
Texto Completo: https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329
Resumo: Objective: This study aims to evaluate the effects of omega-3-rich fish oil supplementation with or without physical activity on anti-inflammatory and insulin resistance parameters in obese and type 2 diabetic individuals. Methods: Randomized, double-blind intervention study of omega-3. Adults with obesity and type 2 diabetes mellitus on exclusive use of metformin as a drug to control blood glucose will be included. The Protocol will be based on clinical and nutritional follow-up (supplementation with omega-3) and remote physical activity for eight weeks. Individuals selected for the study will be randomly assigned to one of the following groups: i) omega-3; ii) omega-3 + physical activity; iii) physical activity + placebo; iv) placebo. To analyze the results, biochemical parameters (fasting glucose and insulin, glycosylated hemoglobin, liver enzymes, urea, creatinine, total cholesterol and fractions, triglycerides, CRP, and ferritin) and inflammatory parameters (TNF alpha, IL-1 beta, IL- 6 and IL-10). At the end of the study, it is expected that the intervention associated with omega-3 in the physical activity protocol will promote a reduction in parameters related to insulin resistance, levels of inflammatory cytokines, and anthropometric parameters.
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spelling Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocolEfeitos da suplementação de ômega-3 associado à atividade física em pacientes obesos portadores de diabetes mellitus do tipo 2: protocolo de estudo.Diabetes Mellitus Type 2ExerciseFatty Acids Omega-3ObesityObesidadeDiabetes Mellitus Tipo 2Ácidos Graxos Ômega-3Exercício FísicoObjective: This study aims to evaluate the effects of omega-3-rich fish oil supplementation with or without physical activity on anti-inflammatory and insulin resistance parameters in obese and type 2 diabetic individuals. Methods: Randomized, double-blind intervention study of omega-3. Adults with obesity and type 2 diabetes mellitus on exclusive use of metformin as a drug to control blood glucose will be included. The Protocol will be based on clinical and nutritional follow-up (supplementation with omega-3) and remote physical activity for eight weeks. Individuals selected for the study will be randomly assigned to one of the following groups: i) omega-3; ii) omega-3 + physical activity; iii) physical activity + placebo; iv) placebo. To analyze the results, biochemical parameters (fasting glucose and insulin, glycosylated hemoglobin, liver enzymes, urea, creatinine, total cholesterol and fractions, triglycerides, CRP, and ferritin) and inflammatory parameters (TNF alpha, IL-1 beta, IL- 6 and IL-10). At the end of the study, it is expected that the intervention associated with omega-3 in the physical activity protocol will promote a reduction in parameters related to insulin resistance, levels of inflammatory cytokines, and anthropometric parameters.Objetivo: O objetivo deste estudo será avaliar os efeitos de uma suplementação com óleo de peixe rico em ômega-3 associada ou não à atividade física sobre parâmetros anti-inflamatórios e de resistência à insulina em indivíduos obesos e diabéticos tipo 2. Métodos: Estudo randomizado, duplamente cegado para intervenção de ômega-3. Serão incluídos indivíduos adultos com obesidade, portadores de diabetes mellitus tipo 2 em uso exclusivo de metformina, como medicamento para controle da glicemia. O Protocolo será baseado em acompanhamento clínico, nutricional (suplementação com ômega-3) e atividade física remota por período de oito semanas. Os indivíduos selecionados para o estudo serão aleatoriamente encaminhados para um dos grupos: i) ômega-3; ii) ômega-3 + atividade física; iii) atividade física + placebo; iv) placebo. Para a análise dos resultados serão avaliados parâmetros bioquímicos (glicemia e insulina de jejum, hemoglobina glicosilada, enzimas hepáticas, ureia, creatinina, colesterol total e frações, triglicerídeos, PCR e ferritina) e inflamatórios (TNF alfa, IL-1 beta, IL-6 e IL-10). Ao final do estudo, espera-se que a intervenção associada de ômega-3 ao protocolo de atividade física promova redução de parâmetros relacionados à resistência insulínica, aos níveis de citocinas inflamatórias e aos parâmetros antropométricos.AISI/HCI2022-12-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos parestextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdfhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/132910.21876/rcshci.v12i4.1329Revista Ciências em Saúde; v. 12 n. 4 (2022): Outubro a Dezembro de 2022; 28-34Health Sciences Journal; Vol 12 No 4 (2022): October to December 2022; 28-342236-378510.21876/rcshci.v12i4reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIengporhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329/846https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329/847Copyright (c) 2022 Revista Ciências em Saúdehttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessCardoso de Lima, Mário Flávio Fraga Lopes, Marina GuedesJusto Neto, Wellington Henrique de Souza, Cláudio Teodoro2022-12-19T02:15:24Zoai:ojs.portalrcs.hcitajuba.org.br:article/1329Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2022-12-19T02:15:24Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse
dc.title.none.fl_str_mv Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
Efeitos da suplementação de ômega-3 associado à atividade física em pacientes obesos portadores de diabetes mellitus do tipo 2: protocolo de estudo.
title Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
spellingShingle Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
Cardoso de Lima, Mário Flávio
Diabetes Mellitus Type 2
Exercise
Fatty Acids Omega-3
Obesity
Obesidade
Diabetes Mellitus Tipo 2
Ácidos Graxos Ômega-3
Exercício Físico
title_short Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
title_full Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
title_fullStr Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
title_full_unstemmed Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
title_sort Effects of omega-3 supplementation associated with physical activity in obese patients with type 2 diabetes mellitus: study protocol
author Cardoso de Lima, Mário Flávio
author_facet Cardoso de Lima, Mário Flávio
Fraga Lopes, Marina Guedes
Justo Neto, Wellington Henrique
de Souza, Cláudio Teodoro
author_role author
author2 Fraga Lopes, Marina Guedes
Justo Neto, Wellington Henrique
de Souza, Cláudio Teodoro
author2_role author
author
author
dc.contributor.author.fl_str_mv Cardoso de Lima, Mário Flávio
Fraga Lopes, Marina Guedes
Justo Neto, Wellington Henrique
de Souza, Cláudio Teodoro
dc.subject.por.fl_str_mv Diabetes Mellitus Type 2
Exercise
Fatty Acids Omega-3
Obesity
Obesidade
Diabetes Mellitus Tipo 2
Ácidos Graxos Ômega-3
Exercício Físico
topic Diabetes Mellitus Type 2
Exercise
Fatty Acids Omega-3
Obesity
Obesidade
Diabetes Mellitus Tipo 2
Ácidos Graxos Ômega-3
Exercício Físico
description Objective: This study aims to evaluate the effects of omega-3-rich fish oil supplementation with or without physical activity on anti-inflammatory and insulin resistance parameters in obese and type 2 diabetic individuals. Methods: Randomized, double-blind intervention study of omega-3. Adults with obesity and type 2 diabetes mellitus on exclusive use of metformin as a drug to control blood glucose will be included. The Protocol will be based on clinical and nutritional follow-up (supplementation with omega-3) and remote physical activity for eight weeks. Individuals selected for the study will be randomly assigned to one of the following groups: i) omega-3; ii) omega-3 + physical activity; iii) physical activity + placebo; iv) placebo. To analyze the results, biochemical parameters (fasting glucose and insulin, glycosylated hemoglobin, liver enzymes, urea, creatinine, total cholesterol and fractions, triglycerides, CRP, and ferritin) and inflammatory parameters (TNF alpha, IL-1 beta, IL- 6 and IL-10). At the end of the study, it is expected that the intervention associated with omega-3 in the physical activity protocol will promote a reduction in parameters related to insulin resistance, levels of inflammatory cytokines, and anthropometric parameters.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer reviewed
Avaliado pelos pares
texto
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329
10.21876/rcshci.v12i4.1329
url https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329
identifier_str_mv 10.21876/rcshci.v12i4.1329
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329/846
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1329/847
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Ciências em Saúde
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Ciências em Saúde
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AISI/HCI
publisher.none.fl_str_mv AISI/HCI
dc.source.none.fl_str_mv Revista Ciências em Saúde; v. 12 n. 4 (2022): Outubro a Dezembro de 2022; 28-34
Health Sciences Journal; Vol 12 No 4 (2022): October to December 2022; 28-34
2236-3785
10.21876/rcshci.v12i4
reponame:Revista Ciências em Saúde
instname:Hospital de Clínicas de Itajubá
instacron:HCI
instname_str Hospital de Clínicas de Itajubá
instacron_str HCI
institution HCI
reponame_str Revista Ciências em Saúde
collection Revista Ciências em Saúde
repository.name.fl_str_mv Revista Ciências em Saúde - Hospital de Clínicas de Itajubá
repository.mail.fl_str_mv rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br
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