Animal models for inducing inflammatory bowel diseases: integrative review
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | por eng |
| Título da fonte: | Revista Ciências em Saúde |
| Texto Completo: | https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056 |
Resumo: | Objective: To identify and describe comparatively the chemical models of the induction of inflammatory bowel diseases (IBD) in rodents most used and that best mimic the pathogenesis in humans. Methods: Based on an integrative review in the MEDLINE and LILACS databases, it was investigated which experimental induction models were most cited in articles published from 2004 to 2020, with the descriptors "Colitis/CI", "Colitis model ulcerative" and "Intestinal inflammation model." All empirical articles that addressed one or more inflammation models in rats or mice were included. Results: 239 articles were identified; of these, only ten empirical articles were selected. The most used models were colitis induced by TNBS acid, DSS, and colitis induced by acetic acid (AA). Conclusion: It was possible to identify the most used models to promote the induction of intestinal inflammation in rats, and both models proved to be effective according to the limitations observed in the models described, suggesting the need for new works that use more well-defined protocols and that more fully represent the pathophysiological complexity of the disease. |
| id |
RCS_fb19c85e26ffdaf035afbcfc1f1c263d |
|---|---|
| oai_identifier_str |
oai:ojs.portalrcs.hcitajuba.org.br:article/1056 |
| network_acronym_str |
RCS |
| network_name_str |
Revista Ciências em Saúde |
| repository_id_str |
|
| spelling |
Animal models for inducing inflammatory bowel diseases: integrative reviewModelos animais de indução das doenças inflamatórias intestinais: revisão integrativainflammatory bowel diseasesulcerative colitisanimal disease modelsdoenças inflamatórias intestinaiscolite ulcerativamodelos animais de doençasObjective: To identify and describe comparatively the chemical models of the induction of inflammatory bowel diseases (IBD) in rodents most used and that best mimic the pathogenesis in humans. Methods: Based on an integrative review in the MEDLINE and LILACS databases, it was investigated which experimental induction models were most cited in articles published from 2004 to 2020, with the descriptors "Colitis/CI", "Colitis model ulcerative" and "Intestinal inflammation model." All empirical articles that addressed one or more inflammation models in rats or mice were included. Results: 239 articles were identified; of these, only ten empirical articles were selected. The most used models were colitis induced by TNBS acid, DSS, and colitis induced by acetic acid (AA). Conclusion: It was possible to identify the most used models to promote the induction of intestinal inflammation in rats, and both models proved to be effective according to the limitations observed in the models described, suggesting the need for new works that use more well-defined protocols and that more fully represent the pathophysiological complexity of the disease.Objetivo: Identificar e descrever de forma comparativa os modelos químicos de indução das doenças inflamatórias intestinais (DII) em roedores mais utilizados e que melhor mimetizam a patogênese em humanos. Métodos: a partir de uma revisão integrativa nas bases de dados MEDLINE e LILACS, investigou-se quais os modelos de indução experimental mais citados nos artigos publicados no período de 2004 a 2020, com os descritores “Colite/CI", “Modelo de colite ulcerativa” e “Modelo de inflamação intestinal”. Foram incluídos todos os artigos empíricos que abordassem um ou mais modelos de inflamação em ratos ou camundongos. Resultados: 239 artigos foram identificados; destes, somente dez artigos empíricos foram selecionados. Os modelos mais utilizados foram o de colite induzida por ácido TNBS, por DSS e colite induzida por ácido acético (AA). Conclusão: Foi possivel identificar os modelos mais utilizados para promover a indução da inflamação intestinal em ratos e ambos os modelos se mostraram eficazes de acordo com seu protocolo de indução. Ficaram claras as limitações observadas nos modelos já descritos, sugerindo a necessidade de novos trabalhos que utilizem protocolos mais bem definidos e que representem de forma mais integral a complexidade fisiopatológica da doença.AISI/HCI2021-03-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer reviewedAvaliado pelos parestextoinfo:eu-repo/semantics/otherapplication/pdfapplication/pdftext/xmltext/htmlhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/105610.21876/rcshci.v11i1.1056Revista Ciências em Saúde; v. 11 n. 1 (2021): Janeiro a Março de 2021; 80-87Health Sciences Journal; Vol 11 No 1 (2021): January to March 2021; 80-872236-378510.21876/rcshci.v11i1reponame:Revista Ciências em Saúdeinstname:Hospital de Clínicas de Itajubáinstacron:HCIporenghttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056/688https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056/689https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056/698https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056/699Copyright (c) 2021 Revista Ciências em Saúdehttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessMelo, Nadja Maria da CostaAlmeida, Marília Virgo SilvaCampos, Daniel Melo de OliveiraOliveira, Claudio Bruno Silva deOliveira, Jonas Ivan Nobre2021-06-27T04:43:38Zoai:ojs.portalrcs.hcitajuba.org.br:article/1056Revistahttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zeroPUBhttps://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/oaircs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br2236-37852236-3785opendoar:2021-06-27T04:43:38Revista Ciências em Saúde - Hospital de Clínicas de Itajubáfalse |
| dc.title.none.fl_str_mv |
Animal models for inducing inflammatory bowel diseases: integrative review Modelos animais de indução das doenças inflamatórias intestinais: revisão integrativa |
| title |
Animal models for inducing inflammatory bowel diseases: integrative review |
| spellingShingle |
Animal models for inducing inflammatory bowel diseases: integrative review Melo, Nadja Maria da Costa inflammatory bowel diseases ulcerative colitis animal disease models doenças inflamatórias intestinais colite ulcerativa modelos animais de doenças |
| title_short |
Animal models for inducing inflammatory bowel diseases: integrative review |
| title_full |
Animal models for inducing inflammatory bowel diseases: integrative review |
| title_fullStr |
Animal models for inducing inflammatory bowel diseases: integrative review |
| title_full_unstemmed |
Animal models for inducing inflammatory bowel diseases: integrative review |
| title_sort |
Animal models for inducing inflammatory bowel diseases: integrative review |
| author |
Melo, Nadja Maria da Costa |
| author_facet |
Melo, Nadja Maria da Costa Almeida, Marília Virgo Silva Campos, Daniel Melo de Oliveira Oliveira, Claudio Bruno Silva de Oliveira, Jonas Ivan Nobre |
| author_role |
author |
| author2 |
Almeida, Marília Virgo Silva Campos, Daniel Melo de Oliveira Oliveira, Claudio Bruno Silva de Oliveira, Jonas Ivan Nobre |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Melo, Nadja Maria da Costa Almeida, Marília Virgo Silva Campos, Daniel Melo de Oliveira Oliveira, Claudio Bruno Silva de Oliveira, Jonas Ivan Nobre |
| dc.subject.por.fl_str_mv |
inflammatory bowel diseases ulcerative colitis animal disease models doenças inflamatórias intestinais colite ulcerativa modelos animais de doenças |
| topic |
inflammatory bowel diseases ulcerative colitis animal disease models doenças inflamatórias intestinais colite ulcerativa modelos animais de doenças |
| description |
Objective: To identify and describe comparatively the chemical models of the induction of inflammatory bowel diseases (IBD) in rodents most used and that best mimic the pathogenesis in humans. Methods: Based on an integrative review in the MEDLINE and LILACS databases, it was investigated which experimental induction models were most cited in articles published from 2004 to 2020, with the descriptors "Colitis/CI", "Colitis model ulcerative" and "Intestinal inflammation model." All empirical articles that addressed one or more inflammation models in rats or mice were included. Results: 239 articles were identified; of these, only ten empirical articles were selected. The most used models were colitis induced by TNBS acid, DSS, and colitis induced by acetic acid (AA). Conclusion: It was possible to identify the most used models to promote the induction of intestinal inflammation in rats, and both models proved to be effective according to the limitations observed in the models described, suggesting the need for new works that use more well-defined protocols and that more fully represent the pathophysiological complexity of the disease. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-03-23 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer reviewed Avaliado pelos pares texto info:eu-repo/semantics/other |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056 10.21876/rcshci.v11i1.1056 |
| url |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056 |
| identifier_str_mv |
10.21876/rcshci.v11i1.1056 |
| dc.language.iso.fl_str_mv |
por eng |
| language |
por eng |
| dc.relation.none.fl_str_mv |
https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056/688 https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056/689 https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056/698 https://portalrcs.hcitajuba.org.br/index.php/rcsfmit_zero/article/view/1056/699 |
| dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Revista Ciências em Saúde https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Copyright (c) 2021 Revista Ciências em Saúde https://creativecommons.org/licenses/by-nc-sa/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf text/xml text/html |
| dc.publisher.none.fl_str_mv |
AISI/HCI |
| publisher.none.fl_str_mv |
AISI/HCI |
| dc.source.none.fl_str_mv |
Revista Ciências em Saúde; v. 11 n. 1 (2021): Janeiro a Março de 2021; 80-87 Health Sciences Journal; Vol 11 No 1 (2021): January to March 2021; 80-87 2236-3785 10.21876/rcshci.v11i1 reponame:Revista Ciências em Saúde instname:Hospital de Clínicas de Itajubá instacron:HCI |
| instname_str |
Hospital de Clínicas de Itajubá |
| instacron_str |
HCI |
| institution |
HCI |
| reponame_str |
Revista Ciências em Saúde |
| collection |
Revista Ciências em Saúde |
| repository.name.fl_str_mv |
Revista Ciências em Saúde - Hospital de Clínicas de Itajubá |
| repository.mail.fl_str_mv |
rcs@hcitajuba.org.br||rcsfmit@medicinaitajuba.com.br |
| _version_ |
1797068963185688576 |