Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications

Detalhes bibliográficos
Autor(a) principal: Yazdani,Javad
Data de Publicação: 2019
Outros Autores: Khorshidi Khiavi,Reza, Ghavimi,Mohammad Ali, Mortazavi,Ali, Jabbari Hagh,Elahe, Ahmadpour,Farzin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Anestesiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942019000600594
Resumo: Abstract Background and objectives: Calcitonin is a polypeptide hormone regulating the metabolism of calcium in the body. For many years calcitonin has been used to maintain and improve bone mineral density and to reduce the fracture rate. Many studies showed that calcitonin had analgesic role in several painful circumstances. This pain-ameliorating effect is irrelevant to its osteoclastic inhibitory effect and mechanisms like altering Na+ channel and serotonin receptor expression or hypothesis including the endorphin-mediated mechanism were used to explain this effect. In this study we performed a thorough review on the role of calcitonin as an analgesic agent in different scenarios and investigated the fact that calcitonin can be a feasible medication to relieve pain. Method: Many studies focused on the analgesic effect of calcitonin in several painful circumstances, including acute pains related to vertebral fractures, metastasis, migraine and reflex sympathetic dystrophy as well as neuropathic pains related to spinal injuries or diabetes, and phantom pain. Also, calcitonin was showed to be a useful additive to local anesthesia in the case of controlling postoperative pain or trigeminal neuralgia more effectively. However we faced some contradictory data for conditions like lumbar canal stenosis, complex regional pain syndrome, phantom pain and malignancies. Conclusion: This study showed that calcitonin could be helpful analgesic agent in different painful situations. Calcitonin can be considered an eligible treatment for acute pains related to vertebral fractures and a feasible alternative for the treatment of the acute and chronic neuropathic pains where other medications might fail.
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spelling Calcitonin as an analgesic agent: review of mechanisms of action and clinical applicationsCalcitoninAcute painChronic painSpinal fracturesMalignancyMigrainePhantom painDiabetic neuropathiesAbstract Background and objectives: Calcitonin is a polypeptide hormone regulating the metabolism of calcium in the body. For many years calcitonin has been used to maintain and improve bone mineral density and to reduce the fracture rate. Many studies showed that calcitonin had analgesic role in several painful circumstances. This pain-ameliorating effect is irrelevant to its osteoclastic inhibitory effect and mechanisms like altering Na+ channel and serotonin receptor expression or hypothesis including the endorphin-mediated mechanism were used to explain this effect. In this study we performed a thorough review on the role of calcitonin as an analgesic agent in different scenarios and investigated the fact that calcitonin can be a feasible medication to relieve pain. Method: Many studies focused on the analgesic effect of calcitonin in several painful circumstances, including acute pains related to vertebral fractures, metastasis, migraine and reflex sympathetic dystrophy as well as neuropathic pains related to spinal injuries or diabetes, and phantom pain. Also, calcitonin was showed to be a useful additive to local anesthesia in the case of controlling postoperative pain or trigeminal neuralgia more effectively. However we faced some contradictory data for conditions like lumbar canal stenosis, complex regional pain syndrome, phantom pain and malignancies. Conclusion: This study showed that calcitonin could be helpful analgesic agent in different painful situations. Calcitonin can be considered an eligible treatment for acute pains related to vertebral fractures and a feasible alternative for the treatment of the acute and chronic neuropathic pains where other medications might fail.Sociedade Brasileira de Anestesiologia2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942019000600594Revista Brasileira de Anestesiologia v.69 n.6 2019reponame:Revista Brasileira de Anestesiologia (Online)instname:Sociedade Brasileira de Anestesiologia (SBA)instacron:SBA10.1016/j.bjane.2019.08.003info:eu-repo/semantics/openAccessYazdani,JavadKhorshidi Khiavi,RezaGhavimi,Mohammad AliMortazavi,AliJabbari Hagh,ElaheAhmadpour,Farzineng2020-02-05T00:00:00Zoai:scielo:S0034-70942019000600594Revistahttps://www.sbahq.org/revista/https://old.scielo.br/oai/scielo-oai.php||sba2000@openlink.com.br1806-907X0034-7094opendoar:2020-02-05T00:00Revista Brasileira de Anestesiologia (Online) - Sociedade Brasileira de Anestesiologia (SBA)false
dc.title.none.fl_str_mv Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications
title Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications
spellingShingle Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications
Yazdani,Javad
Calcitonin
Acute pain
Chronic pain
Spinal fractures
Malignancy
Migraine
Phantom pain
Diabetic neuropathies
title_short Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications
title_full Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications
title_fullStr Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications
title_full_unstemmed Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications
title_sort Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications
author Yazdani,Javad
author_facet Yazdani,Javad
Khorshidi Khiavi,Reza
Ghavimi,Mohammad Ali
Mortazavi,Ali
Jabbari Hagh,Elahe
Ahmadpour,Farzin
author_role author
author2 Khorshidi Khiavi,Reza
Ghavimi,Mohammad Ali
Mortazavi,Ali
Jabbari Hagh,Elahe
Ahmadpour,Farzin
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Yazdani,Javad
Khorshidi Khiavi,Reza
Ghavimi,Mohammad Ali
Mortazavi,Ali
Jabbari Hagh,Elahe
Ahmadpour,Farzin
dc.subject.por.fl_str_mv Calcitonin
Acute pain
Chronic pain
Spinal fractures
Malignancy
Migraine
Phantom pain
Diabetic neuropathies
topic Calcitonin
Acute pain
Chronic pain
Spinal fractures
Malignancy
Migraine
Phantom pain
Diabetic neuropathies
description Abstract Background and objectives: Calcitonin is a polypeptide hormone regulating the metabolism of calcium in the body. For many years calcitonin has been used to maintain and improve bone mineral density and to reduce the fracture rate. Many studies showed that calcitonin had analgesic role in several painful circumstances. This pain-ameliorating effect is irrelevant to its osteoclastic inhibitory effect and mechanisms like altering Na+ channel and serotonin receptor expression or hypothesis including the endorphin-mediated mechanism were used to explain this effect. In this study we performed a thorough review on the role of calcitonin as an analgesic agent in different scenarios and investigated the fact that calcitonin can be a feasible medication to relieve pain. Method: Many studies focused on the analgesic effect of calcitonin in several painful circumstances, including acute pains related to vertebral fractures, metastasis, migraine and reflex sympathetic dystrophy as well as neuropathic pains related to spinal injuries or diabetes, and phantom pain. Also, calcitonin was showed to be a useful additive to local anesthesia in the case of controlling postoperative pain or trigeminal neuralgia more effectively. However we faced some contradictory data for conditions like lumbar canal stenosis, complex regional pain syndrome, phantom pain and malignancies. Conclusion: This study showed that calcitonin could be helpful analgesic agent in different painful situations. Calcitonin can be considered an eligible treatment for acute pains related to vertebral fractures and a feasible alternative for the treatment of the acute and chronic neuropathic pains where other medications might fail.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942019000600594
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942019000600594
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjane.2019.08.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Anestesiologia
publisher.none.fl_str_mv Sociedade Brasileira de Anestesiologia
dc.source.none.fl_str_mv Revista Brasileira de Anestesiologia v.69 n.6 2019
reponame:Revista Brasileira de Anestesiologia (Online)
instname:Sociedade Brasileira de Anestesiologia (SBA)
instacron:SBA
instname_str Sociedade Brasileira de Anestesiologia (SBA)
instacron_str SBA
institution SBA
reponame_str Revista Brasileira de Anestesiologia (Online)
collection Revista Brasileira de Anestesiologia (Online)
repository.name.fl_str_mv Revista Brasileira de Anestesiologia (Online) - Sociedade Brasileira de Anestesiologia (SBA)
repository.mail.fl_str_mv ||sba2000@openlink.com.br
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