Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Cardiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200223 |
Resumo: | Abstract Background: Despite the important biological effects of jabuticaba, its actions on the cardiovascular system have not been clarified. Objectives: To determine the effects of jabuticaba hydroalcoholic extract (JHE) on vascular smooth muscle (VSM) of isolated arteries. Methods: Endothelium-denuded aortic rings of rats were mounted in isolated organ bath to record isometric tension. The relaxant effect of JHE and the influence of K+ channels and Ca2+ intra- and extracellular sources on JHE-stimulated response were assessed. Results: Arteries pre-contracted with phenylephrine showed concentration-dependent relaxation (0.380 to 1.92 mg/mL). Treatment with K+ channel blockers (tetraethyl-ammonium, glibenclamide, 4-aminopyridine) hindered relaxation due to JHE. In addition, phenylephrine-stimulated contraction was hindered by previous treatment with JHE. Inhibition of sarcoplasmic reticulum Ca2+ ATPase did not change relaxation due to JHE. In addition, JHE inhibited the contraction caused by Ca2+ influx stimulated by phenylephrine and KCl (75 mM). Conclusion: JHE induces endothelium-independent vasodilation. Activation of K+ channels and inhibition of Ca2+ influx through the membrane are involved in the JHE relaxant effect. |
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Arquivos Brasileiros de Cardiologia (Online) |
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Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated ArteriesJabuticaba (Myrciaria Cauliflora)TreesVasodilatationCalcium ChannelsMuscle, Smooth VascularAbstract Background: Despite the important biological effects of jabuticaba, its actions on the cardiovascular system have not been clarified. Objectives: To determine the effects of jabuticaba hydroalcoholic extract (JHE) on vascular smooth muscle (VSM) of isolated arteries. Methods: Endothelium-denuded aortic rings of rats were mounted in isolated organ bath to record isometric tension. The relaxant effect of JHE and the influence of K+ channels and Ca2+ intra- and extracellular sources on JHE-stimulated response were assessed. Results: Arteries pre-contracted with phenylephrine showed concentration-dependent relaxation (0.380 to 1.92 mg/mL). Treatment with K+ channel blockers (tetraethyl-ammonium, glibenclamide, 4-aminopyridine) hindered relaxation due to JHE. In addition, phenylephrine-stimulated contraction was hindered by previous treatment with JHE. Inhibition of sarcoplasmic reticulum Ca2+ ATPase did not change relaxation due to JHE. In addition, JHE inhibited the contraction caused by Ca2+ influx stimulated by phenylephrine and KCl (75 mM). Conclusion: JHE induces endothelium-independent vasodilation. Activation of K+ channels and inhibition of Ca2+ influx through the membrane are involved in the JHE relaxant effect.Sociedade Brasileira de Cardiologia - SBC2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200223Arquivos Brasileiros de Cardiologia v.107 n.3 2016reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20160118info:eu-repo/semantics/openAccessAndrade,Daniela Medeiros Lobo deBorges,Leonardo LuisTorres,Ieda Maria SapateiroConceição,Edemilson Cardoso daRocha,Matheus Lavorentieng2016-10-05T00:00:00Zoai:scielo:S0066-782X2016004200223Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2016-10-05T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries |
title |
Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries |
spellingShingle |
Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries Andrade,Daniela Medeiros Lobo de Jabuticaba (Myrciaria Cauliflora) Trees Vasodilatation Calcium Channels Muscle, Smooth Vascular |
title_short |
Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries |
title_full |
Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries |
title_fullStr |
Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries |
title_full_unstemmed |
Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries |
title_sort |
Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries |
author |
Andrade,Daniela Medeiros Lobo de |
author_facet |
Andrade,Daniela Medeiros Lobo de Borges,Leonardo Luis Torres,Ieda Maria Sapateiro Conceição,Edemilson Cardoso da Rocha,Matheus Lavorenti |
author_role |
author |
author2 |
Borges,Leonardo Luis Torres,Ieda Maria Sapateiro Conceição,Edemilson Cardoso da Rocha,Matheus Lavorenti |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Andrade,Daniela Medeiros Lobo de Borges,Leonardo Luis Torres,Ieda Maria Sapateiro Conceição,Edemilson Cardoso da Rocha,Matheus Lavorenti |
dc.subject.por.fl_str_mv |
Jabuticaba (Myrciaria Cauliflora) Trees Vasodilatation Calcium Channels Muscle, Smooth Vascular |
topic |
Jabuticaba (Myrciaria Cauliflora) Trees Vasodilatation Calcium Channels Muscle, Smooth Vascular |
description |
Abstract Background: Despite the important biological effects of jabuticaba, its actions on the cardiovascular system have not been clarified. Objectives: To determine the effects of jabuticaba hydroalcoholic extract (JHE) on vascular smooth muscle (VSM) of isolated arteries. Methods: Endothelium-denuded aortic rings of rats were mounted in isolated organ bath to record isometric tension. The relaxant effect of JHE and the influence of K+ channels and Ca2+ intra- and extracellular sources on JHE-stimulated response were assessed. Results: Arteries pre-contracted with phenylephrine showed concentration-dependent relaxation (0.380 to 1.92 mg/mL). Treatment with K+ channel blockers (tetraethyl-ammonium, glibenclamide, 4-aminopyridine) hindered relaxation due to JHE. In addition, phenylephrine-stimulated contraction was hindered by previous treatment with JHE. Inhibition of sarcoplasmic reticulum Ca2+ ATPase did not change relaxation due to JHE. In addition, JHE inhibited the contraction caused by Ca2+ influx stimulated by phenylephrine and KCl (75 mM). Conclusion: JHE induces endothelium-independent vasodilation. Activation of K+ channels and inhibition of Ca2+ influx through the membrane are involved in the JHE relaxant effect. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200223 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200223 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/abc.20160118 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia v.107 n.3 2016 reponame:Arquivos Brasileiros de Cardiologia (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
Arquivos Brasileiros de Cardiologia (Online) |
collection |
Arquivos Brasileiros de Cardiologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
||arquivos@cardiol.br |
_version_ |
1752126566763069440 |