Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Cardiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2000000800005 |
Resumo: | OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure. |
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Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiographymyocardial infarctrat heartsDoppler echocardiogramOBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.Sociedade Brasileira de Cardiologia - SBC2000-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2000000800005Arquivos Brasileiros de Cardiologia v.75 n.2 2000reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.1590/S0066-782X2000000800005info:eu-repo/semantics/openAccessMoisés,Valdir A.Ferreira,Ricardo L.Nozawa,EmíliaKanashiro,Rosemeire M.Campos Fº,OrlandoAndrade,José Lázaro deCarvalho,Antonio Carlos C.Tucci,Paulo J. F.eng2002-01-08T00:00:00Zoai:scielo:S0066-782X2000000800005Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2002-01-08T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
spellingShingle |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography Moisés,Valdir A. myocardial infarct rat hearts Doppler echocardiogram |
title_short |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title_full |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title_fullStr |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title_full_unstemmed |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
title_sort |
Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography |
author |
Moisés,Valdir A. |
author_facet |
Moisés,Valdir A. Ferreira,Ricardo L. Nozawa,Emília Kanashiro,Rosemeire M. Campos Fº,Orlando Andrade,José Lázaro de Carvalho,Antonio Carlos C. Tucci,Paulo J. F. |
author_role |
author |
author2 |
Ferreira,Ricardo L. Nozawa,Emília Kanashiro,Rosemeire M. Campos Fº,Orlando Andrade,José Lázaro de Carvalho,Antonio Carlos C. Tucci,Paulo J. F. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Moisés,Valdir A. Ferreira,Ricardo L. Nozawa,Emília Kanashiro,Rosemeire M. Campos Fº,Orlando Andrade,José Lázaro de Carvalho,Antonio Carlos C. Tucci,Paulo J. F. |
dc.subject.por.fl_str_mv |
myocardial infarct rat hearts Doppler echocardiogram |
topic |
myocardial infarct rat hearts Doppler echocardiogram |
description |
OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2000000800005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2000000800005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0066-782X2000000800005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia v.75 n.2 2000 reponame:Arquivos Brasileiros de Cardiologia (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
Arquivos Brasileiros de Cardiologia (Online) |
collection |
Arquivos Brasileiros de Cardiologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
||arquivos@cardiol.br |
_version_ |
1752126551297622016 |