Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography

Detalhes bibliográficos
Autor(a) principal: Moisés,Valdir A.
Data de Publicação: 2000
Outros Autores: Ferreira,Ricardo L., Nozawa,Emília, Kanashiro,Rosemeire M., Campos Fº,Orlando, Andrade,José Lázaro de, Carvalho,Antonio Carlos C., Tucci,Paulo J. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2000000800005
Resumo: OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.
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spelling Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiographymyocardial infarctrat heartsDoppler echocardiogramOBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.Sociedade Brasileira de Cardiologia - SBC2000-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2000000800005Arquivos Brasileiros de Cardiologia v.75 n.2 2000reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.1590/S0066-782X2000000800005info:eu-repo/semantics/openAccessMoisés,Valdir A.Ferreira,Ricardo L.Nozawa,EmíliaKanashiro,Rosemeire M.Campos Fº,OrlandoAndrade,José Lázaro deCarvalho,Antonio Carlos C.Tucci,Paulo J. F.eng2002-01-08T00:00:00Zoai:scielo:S0066-782X2000000800005Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2002-01-08T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
spellingShingle Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
Moisés,Valdir A.
myocardial infarct
rat hearts
Doppler echocardiogram
title_short Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title_full Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title_fullStr Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title_full_unstemmed Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title_sort Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
author Moisés,Valdir A.
author_facet Moisés,Valdir A.
Ferreira,Ricardo L.
Nozawa,Emília
Kanashiro,Rosemeire M.
Campos Fº,Orlando
Andrade,José Lázaro de
Carvalho,Antonio Carlos C.
Tucci,Paulo J. F.
author_role author
author2 Ferreira,Ricardo L.
Nozawa,Emília
Kanashiro,Rosemeire M.
Campos Fº,Orlando
Andrade,José Lázaro de
Carvalho,Antonio Carlos C.
Tucci,Paulo J. F.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moisés,Valdir A.
Ferreira,Ricardo L.
Nozawa,Emília
Kanashiro,Rosemeire M.
Campos Fº,Orlando
Andrade,José Lázaro de
Carvalho,Antonio Carlos C.
Tucci,Paulo J. F.
dc.subject.por.fl_str_mv myocardial infarct
rat hearts
Doppler echocardiogram
topic myocardial infarct
rat hearts
Doppler echocardiogram
description OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.
publishDate 2000
dc.date.none.fl_str_mv 2000-08-01
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.75 n.2 2000
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
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reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv ||arquivos@cardiol.br
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