Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography

Detalhes bibliográficos
Autor(a) principal: Moisés, Valdir Ambrósio [UNIFESP]
Data de Publicação: 2000
Outros Autores: Ferreira, Ricardo L. [UNIFESP], Nozawa, Emília [UNIFESP], Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP], Campos Filho, Orlando [UNIFESP], Andrade, José Lazaro de [UNIFESP], Carvalho, Antonio Carlos [UNIFESP], Tucci, Paulo José Ferreira [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0066-782X2000000800005
http://repositorio.unifesp.br/handle/11600/1011
Resumo: OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.
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spelling Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiographymyocardial infarctrat heartsDoppler echocardiogramOBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELOSociedade Brasileira de Cardiologia - SBCUniversidade Federal de São Paulo (UNIFESP)Moisés, Valdir Ambrósio [UNIFESP]Ferreira, Ricardo L. [UNIFESP]Nozawa, Emília [UNIFESP]Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]Campos Filho, Orlando [UNIFESP]Andrade, José Lazaro de [UNIFESP]Carvalho, Antonio Carlos [UNIFESP]Tucci, Paulo José Ferreira [UNIFESP]2015-06-14T13:25:06Z2015-06-14T13:25:06Z2000-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion131-136application/pdfhttp://dx.doi.org/10.1590/S0066-782X2000000800005Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 2, p. 131-136, 2000.10.1590/S0066-782X2000000800005S0066-782X2000000800005.pdf0066-782XS0066-782X2000000800005http://repositorio.unifesp.br/handle/11600/1011engArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T14:47:01Zoai:repositorio.unifesp.br/:11600/1011Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T14:47:01Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
spellingShingle Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
Moisés, Valdir Ambrósio [UNIFESP]
myocardial infarct
rat hearts
Doppler echocardiogram
title_short Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title_full Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title_fullStr Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title_full_unstemmed Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
title_sort Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography
author Moisés, Valdir Ambrósio [UNIFESP]
author_facet Moisés, Valdir Ambrósio [UNIFESP]
Ferreira, Ricardo L. [UNIFESP]
Nozawa, Emília [UNIFESP]
Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]
Campos Filho, Orlando [UNIFESP]
Andrade, José Lazaro de [UNIFESP]
Carvalho, Antonio Carlos [UNIFESP]
Tucci, Paulo José Ferreira [UNIFESP]
author_role author
author2 Ferreira, Ricardo L. [UNIFESP]
Nozawa, Emília [UNIFESP]
Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]
Campos Filho, Orlando [UNIFESP]
Andrade, José Lazaro de [UNIFESP]
Carvalho, Antonio Carlos [UNIFESP]
Tucci, Paulo José Ferreira [UNIFESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Moisés, Valdir Ambrósio [UNIFESP]
Ferreira, Ricardo L. [UNIFESP]
Nozawa, Emília [UNIFESP]
Kanashiro-Takeuchi, Rosimeire Miyuki [UNIFESP]
Campos Filho, Orlando [UNIFESP]
Andrade, José Lazaro de [UNIFESP]
Carvalho, Antonio Carlos [UNIFESP]
Tucci, Paulo José Ferreira [UNIFESP]
dc.subject.por.fl_str_mv myocardial infarct
rat hearts
Doppler echocardiogram
topic myocardial infarct
rat hearts
Doppler echocardiogram
description OBJECTIVE: To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. METHODS: Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. RESULTS: Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/ A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. CONCLUSION: Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.
publishDate 2000
dc.date.none.fl_str_mv 2000-08-01
2015-06-14T13:25:06Z
2015-06-14T13:25:06Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0066-782X2000000800005
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 2, p. 131-136, 2000.
10.1590/S0066-782X2000000800005
S0066-782X2000000800005.pdf
0066-782X
S0066-782X2000000800005
http://repositorio.unifesp.br/handle/11600/1011
url http://dx.doi.org/10.1590/S0066-782X2000000800005
http://repositorio.unifesp.br/handle/11600/1011
identifier_str_mv Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 2, p. 131-136, 2000.
10.1590/S0066-782X2000000800005
S0066-782X2000000800005.pdf
0066-782X
S0066-782X2000000800005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Cardiologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 131-136
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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