Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern Brazil

Detalhes bibliográficos
Autor(a) principal: Rocha,Luiz Otavio
Data de Publicação: 2020
Outros Autores: Rocha,Eduarda, Succi,Guilherme de Menezes, Brito Junior,Rui Barbosa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2020000200268
Resumo: Abstract Background: Periodontitis and coronary artery disease (CAD) share an inflammatory etiology; there is a recent concern regarding the investigation of an association between these two conditions. Current theories indicate that cytokines and proteins have an important role in this process. C-reactive protein and interleukin-6 are inflammatory derivatives produced in the presence of periodontitis and in the pathophysiology of coronary disease. The polymorphisms of CRP + 1444 C > T and IL6-174 G > C are recognized in the literature as being related to CAD. Objective: This study investigates the association between periodontitis and coronary artery disease, through the presence of PCR and IL-6 polymorphisms. Methods: We selected 80 patients who underwent diagnostic catheterization in the HU of UFSM. The presence of periodontitis was determined by the Community Periodontal Index, whereas the CAD was established by the medical report. DNA was collected from a saliva sample and the presence of polymorphism was determined by PCR and restriction enzymes. A significance level of 5% was adopted. Results: The mean age of all participants (p = 0.035, OR 2.65; 95%CI: (1.02-6.87) male gender (p = 0.012, OR 3.37; 95% CI: (1.28- (p = 0.013, OR 3.66; 95% CI: (1.27-10.5)), PCR polymorphism + 1444C > T (p = 0.001, OR 6.37; 95% CI:, (2.25-17.9)) and IL6 -174 G > C polymorphism (p = 0.025, OR 2.87, 95% CI: (1.09-7.55)) were statistically associated with the presence of CAD. Age > 60 years and presence of the PCR +1444 C > T polymorphism remained independently associated with CAD after adjustment by logistic regression. Conclusions: The presence of the PCR + 1444 C > T polymorphism in this study was independently associated with the presence of coronary artery disease.
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spelling Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern BrazilPeriodontitisPolymorphism, GeneticCoronary Artery DiseaseC-reactive ProteinEpidemiologyAbstract Background: Periodontitis and coronary artery disease (CAD) share an inflammatory etiology; there is a recent concern regarding the investigation of an association between these two conditions. Current theories indicate that cytokines and proteins have an important role in this process. C-reactive protein and interleukin-6 are inflammatory derivatives produced in the presence of periodontitis and in the pathophysiology of coronary disease. The polymorphisms of CRP + 1444 C > T and IL6-174 G > C are recognized in the literature as being related to CAD. Objective: This study investigates the association between periodontitis and coronary artery disease, through the presence of PCR and IL-6 polymorphisms. Methods: We selected 80 patients who underwent diagnostic catheterization in the HU of UFSM. The presence of periodontitis was determined by the Community Periodontal Index, whereas the CAD was established by the medical report. DNA was collected from a saliva sample and the presence of polymorphism was determined by PCR and restriction enzymes. A significance level of 5% was adopted. Results: The mean age of all participants (p = 0.035, OR 2.65; 95%CI: (1.02-6.87) male gender (p = 0.012, OR 3.37; 95% CI: (1.28- (p = 0.013, OR 3.66; 95% CI: (1.27-10.5)), PCR polymorphism + 1444C > T (p = 0.001, OR 6.37; 95% CI:, (2.25-17.9)) and IL6 -174 G > C polymorphism (p = 0.025, OR 2.87, 95% CI: (1.09-7.55)) were statistically associated with the presence of CAD. Age > 60 years and presence of the PCR +1444 C > T polymorphism remained independently associated with CAD after adjustment by logistic regression. Conclusions: The presence of the PCR + 1444 C > T polymorphism in this study was independently associated with the presence of coronary artery disease.Sociedade Brasileira de Cardiologia - SBC2020-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2020000200268Arquivos Brasileiros de Cardiologia v.114 n.2 2020reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.36660/abc.20180296info:eu-repo/semantics/openAccessRocha,Luiz OtavioRocha,EduardaSucci,Guilherme de MenezesBrito Junior,Rui Barbosa deeng2020-09-30T00:00:00Zoai:scielo:S0066-782X2020000200268Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2020-09-30T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern Brazil
title Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern Brazil
spellingShingle Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern Brazil
Rocha,Luiz Otavio
Periodontitis
Polymorphism, Genetic
Coronary Artery Disease
C-reactive Protein
Epidemiology
title_short Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern Brazil
title_full Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern Brazil
title_fullStr Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern Brazil
title_full_unstemmed Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern Brazil
title_sort Association between Periodontitis, Genetic Polymorphisms and Presence of Coronary Artery Disease in Southern Brazil
author Rocha,Luiz Otavio
author_facet Rocha,Luiz Otavio
Rocha,Eduarda
Succi,Guilherme de Menezes
Brito Junior,Rui Barbosa de
author_role author
author2 Rocha,Eduarda
Succi,Guilherme de Menezes
Brito Junior,Rui Barbosa de
author2_role author
author
author
dc.contributor.author.fl_str_mv Rocha,Luiz Otavio
Rocha,Eduarda
Succi,Guilherme de Menezes
Brito Junior,Rui Barbosa de
dc.subject.por.fl_str_mv Periodontitis
Polymorphism, Genetic
Coronary Artery Disease
C-reactive Protein
Epidemiology
topic Periodontitis
Polymorphism, Genetic
Coronary Artery Disease
C-reactive Protein
Epidemiology
description Abstract Background: Periodontitis and coronary artery disease (CAD) share an inflammatory etiology; there is a recent concern regarding the investigation of an association between these two conditions. Current theories indicate that cytokines and proteins have an important role in this process. C-reactive protein and interleukin-6 are inflammatory derivatives produced in the presence of periodontitis and in the pathophysiology of coronary disease. The polymorphisms of CRP + 1444 C > T and IL6-174 G > C are recognized in the literature as being related to CAD. Objective: This study investigates the association between periodontitis and coronary artery disease, through the presence of PCR and IL-6 polymorphisms. Methods: We selected 80 patients who underwent diagnostic catheterization in the HU of UFSM. The presence of periodontitis was determined by the Community Periodontal Index, whereas the CAD was established by the medical report. DNA was collected from a saliva sample and the presence of polymorphism was determined by PCR and restriction enzymes. A significance level of 5% was adopted. Results: The mean age of all participants (p = 0.035, OR 2.65; 95%CI: (1.02-6.87) male gender (p = 0.012, OR 3.37; 95% CI: (1.28- (p = 0.013, OR 3.66; 95% CI: (1.27-10.5)), PCR polymorphism + 1444C > T (p = 0.001, OR 6.37; 95% CI:, (2.25-17.9)) and IL6 -174 G > C polymorphism (p = 0.025, OR 2.87, 95% CI: (1.09-7.55)) were statistically associated with the presence of CAD. Age > 60 years and presence of the PCR +1444 C > T polymorphism remained independently associated with CAD after adjustment by logistic regression. Conclusions: The presence of the PCR + 1444 C > T polymorphism in this study was independently associated with the presence of coronary artery disease.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2020000200268
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.36660/abc.20180296
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.114 n.2 2020
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
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instname_str Sociedade Brasileira de Cardiologia (SBC)
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reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
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repository.mail.fl_str_mv ||arquivos@cardiol.br
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