Cardiac Regeneration using Growth Factors: Advances and Challenges

Detalhes bibliográficos
Autor(a) principal: Rebouças,Juliana de Souza
Data de Publicação: 2016
Outros Autores: Santos-Magalhães,Nereide Stela, Formiga,Fabio Rocha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200271
Resumo: Abstract Myocardial infarction is the most significant manifestation of ischemic heart disease and is associated with high morbidity and mortality. Novel strategies targeting at regenerating the injured myocardium have been investigated, including gene therapy, cell therapy, and the use of growth factors. Growth factor therapy has aroused interest in cardiovascular medicine because of the regeneration mechanisms induced by these biomolecules, including angiogenesis, extracellular matrix remodeling, cardiomyocyte proliferation, stem-cell recruitment, and others. Together, these mechanisms promote myocardial repair and improvement of the cardiac function. This review aims to address the strategic role of growth factor therapy in cardiac regeneration, considering its innovative and multifactorial character in myocardial repair after ischemic injury. Different issues will be discussed, with emphasis on the regeneration mechanisms as a potential therapeutic resource mediated by growth factors, and the challenges to make these proteins therapeutically viable in the field of cardiology and regenerative medicine.
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spelling Cardiac Regeneration using Growth Factors: Advances and ChallengesMyocardial InfarctionMyocardial IschemiaVascular RemodelingIntercellular Signaling Peptides and ProteinsCell-and Tissue Based TherapyAbstract Myocardial infarction is the most significant manifestation of ischemic heart disease and is associated with high morbidity and mortality. Novel strategies targeting at regenerating the injured myocardium have been investigated, including gene therapy, cell therapy, and the use of growth factors. Growth factor therapy has aroused interest in cardiovascular medicine because of the regeneration mechanisms induced by these biomolecules, including angiogenesis, extracellular matrix remodeling, cardiomyocyte proliferation, stem-cell recruitment, and others. Together, these mechanisms promote myocardial repair and improvement of the cardiac function. This review aims to address the strategic role of growth factor therapy in cardiac regeneration, considering its innovative and multifactorial character in myocardial repair after ischemic injury. Different issues will be discussed, with emphasis on the regeneration mechanisms as a potential therapeutic resource mediated by growth factors, and the challenges to make these proteins therapeutically viable in the field of cardiology and regenerative medicine.Sociedade Brasileira de Cardiologia - SBC2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200271Arquivos Brasileiros de Cardiologia v.107 n.3 2016reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20160097info:eu-repo/semantics/openAccessRebouças,Juliana de SouzaSantos-Magalhães,Nereide StelaFormiga,Fabio Rochaeng2016-10-05T00:00:00Zoai:scielo:S0066-782X2016004200271Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2016-10-05T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Cardiac Regeneration using Growth Factors: Advances and Challenges
title Cardiac Regeneration using Growth Factors: Advances and Challenges
spellingShingle Cardiac Regeneration using Growth Factors: Advances and Challenges
Rebouças,Juliana de Souza
Myocardial Infarction
Myocardial Ischemia
Vascular Remodeling
Intercellular Signaling Peptides and Proteins
Cell-and Tissue Based Therapy
title_short Cardiac Regeneration using Growth Factors: Advances and Challenges
title_full Cardiac Regeneration using Growth Factors: Advances and Challenges
title_fullStr Cardiac Regeneration using Growth Factors: Advances and Challenges
title_full_unstemmed Cardiac Regeneration using Growth Factors: Advances and Challenges
title_sort Cardiac Regeneration using Growth Factors: Advances and Challenges
author Rebouças,Juliana de Souza
author_facet Rebouças,Juliana de Souza
Santos-Magalhães,Nereide Stela
Formiga,Fabio Rocha
author_role author
author2 Santos-Magalhães,Nereide Stela
Formiga,Fabio Rocha
author2_role author
author
dc.contributor.author.fl_str_mv Rebouças,Juliana de Souza
Santos-Magalhães,Nereide Stela
Formiga,Fabio Rocha
dc.subject.por.fl_str_mv Myocardial Infarction
Myocardial Ischemia
Vascular Remodeling
Intercellular Signaling Peptides and Proteins
Cell-and Tissue Based Therapy
topic Myocardial Infarction
Myocardial Ischemia
Vascular Remodeling
Intercellular Signaling Peptides and Proteins
Cell-and Tissue Based Therapy
description Abstract Myocardial infarction is the most significant manifestation of ischemic heart disease and is associated with high morbidity and mortality. Novel strategies targeting at regenerating the injured myocardium have been investigated, including gene therapy, cell therapy, and the use of growth factors. Growth factor therapy has aroused interest in cardiovascular medicine because of the regeneration mechanisms induced by these biomolecules, including angiogenesis, extracellular matrix remodeling, cardiomyocyte proliferation, stem-cell recruitment, and others. Together, these mechanisms promote myocardial repair and improvement of the cardiac function. This review aims to address the strategic role of growth factor therapy in cardiac regeneration, considering its innovative and multifactorial character in myocardial repair after ischemic injury. Different issues will be discussed, with emphasis on the regeneration mechanisms as a potential therapeutic resource mediated by growth factors, and the challenges to make these proteins therapeutically viable in the field of cardiology and regenerative medicine.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200271
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2016004200271
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20160097
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.107 n.3 2016
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
instacron_str SBC
institution SBC
reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv ||arquivos@cardiol.br
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