Cardiac Regeneration using Growth Factors: Advances and Challenges

Detalhes bibliográficos
Autor(a) principal: Rebouças, Juliana de Souza
Data de Publicação: 2016
Outros Autores: Magalhães, Nereide Stela Santos, Formiga, Fabio Rocha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16553
Resumo: CNPq
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spelling Rebouças, Juliana de SouzaMagalhães, Nereide Stela SantosFormiga, Fabio Rocha2016-12-15T17:43:44Z2016-12-15T17:43:44Z2016REBOUÇAS, J. S.; MAGALHÃES, N. S. S.; FORMIGA, F. R. Cardiac Regeneration using Growth Factors: Advances and Challenges. Arquivos Brasileiros de Cardiologia, v. 107, n. 3, p. 271-275, 2016.0066-782Xhttps://www.arca.fiocruz.br/handle/icict/1655310.5935/abc.20160097CNPqUniversidade Federal de Pernambuco. UFPE. Laboratório de Imunopatologia Keizo-Asami. Recife, PE, BrasilUniversidade Federal de Pernambuco. UFPE. Laboratório de Imunopatologia Keizo-Asami. Recife, PE, BrasilUniversidade de Pernambuco. UPE. Recife, PE, Brasil / Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilMyocardial infarction is the most significant manifestation of ischemic heart disease and is associated with high morbidity and mortality. Novel strategies targeting at regenerating the injured myocardium have been investigated, including gene therapy, cell therapy, and the use of growth factors. Growth factor therapy has aroused interest in cardiovascular medicine because of the regeneration mechanisms induced by these biomolecules, including angiogenesis, extracellular matrix remodeling, cardiomyocyte proliferation, stem-cell recruitment, and others. Together, these mechanisms promote myocardial repair and improvement of the cardiac function. This review aims to address the strategic role of growth factor therapy in cardiac regeneration, considering its innovative and multifactorial character in myocardial repair after ischemic injury. Different issues will be discussed, with emphasis on the regeneration mechanisms as a potential therapeutic resource mediated by growth factors, and the challenges to make these proteins therapeutically viable in the field of cardiology and regenerative medicine. Resumo O infarto do miocárdio representa a manifestação mais significativa da cardiopatia isquêmica e está associado a elevada morbimortalidade. Novas estratégias vêm sendo investigadas com o intuito de regenerar o miocárdio lesionado, incluindo a terapia gênica, a terapia celular e a utilização de fatores de crescimento. A terapia com fatores de crescimento despertou interesse em medicina cardiovascular, devido aos mecanismos de regeneração induzidos por essas biomoléculas, incluindo angiogênese, remodelamento da matriz extracelular, proliferação de cardiomiócitos e recrutamento de células-tronco, dentre outros. Em conjunto, tais mecanismos promovem a reparação do miocárdio e a melhora da função cardíaca. Esta revisão pretende abordar o papel estratégico da terapia, com fatores de crescimento, para a regeneração cardíaca, considerando seu caráter inovador e multifatorial sobre o reparo do miocárdio após dano isquêmico. Diferentes questões serão discutidas, destacando-se os mecanismos de regeneração como recurso terapêutico potencial mediado por fatores de crescimento e os desafios para tornar essas proteínas terapeuticamente viáveis no âmbito da cardiologia e da medicina regenerativa.engSociedade Brasileira de CardiologiaInfarto do miocárdioIsquemia do miocárdioRemodelação VascularPeptídeos e Proteínas de Sinalização IntercelularTerapia baseada em células e tecidosMyocardial InfarctionMyocardial IschemiaVascular RemodelingIntercellular Signaling Peptides and ProteinsCell-and Tissue Based TherapyCardiac Regeneration using Growth Factors: Advances and Challengesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Cardiac Regeneration using Growth Factors: Advances and Challenges
title Cardiac Regeneration using Growth Factors: Advances and Challenges
spellingShingle Cardiac Regeneration using Growth Factors: Advances and Challenges
Rebouças, Juliana de Souza
Infarto do miocárdio
Isquemia do miocárdio
Remodelação Vascular
Peptídeos e Proteínas de Sinalização Intercelular
Terapia baseada em células e tecidos
Myocardial Infarction
Myocardial Ischemia
Vascular Remodeling
Intercellular Signaling Peptides and Proteins
Cell-and Tissue Based Therapy
title_short Cardiac Regeneration using Growth Factors: Advances and Challenges
title_full Cardiac Regeneration using Growth Factors: Advances and Challenges
title_fullStr Cardiac Regeneration using Growth Factors: Advances and Challenges
title_full_unstemmed Cardiac Regeneration using Growth Factors: Advances and Challenges
title_sort Cardiac Regeneration using Growth Factors: Advances and Challenges
author Rebouças, Juliana de Souza
author_facet Rebouças, Juliana de Souza
Magalhães, Nereide Stela Santos
Formiga, Fabio Rocha
author_role author
author2 Magalhães, Nereide Stela Santos
Formiga, Fabio Rocha
author2_role author
author
dc.contributor.author.fl_str_mv Rebouças, Juliana de Souza
Magalhães, Nereide Stela Santos
Formiga, Fabio Rocha
dc.subject.other.pt_BR.fl_str_mv Infarto do miocárdio
Isquemia do miocárdio
Remodelação Vascular
Peptídeos e Proteínas de Sinalização Intercelular
Terapia baseada em células e tecidos
topic Infarto do miocárdio
Isquemia do miocárdio
Remodelação Vascular
Peptídeos e Proteínas de Sinalização Intercelular
Terapia baseada em células e tecidos
Myocardial Infarction
Myocardial Ischemia
Vascular Remodeling
Intercellular Signaling Peptides and Proteins
Cell-and Tissue Based Therapy
dc.subject.en.pt_BR.fl_str_mv Myocardial Infarction
Myocardial Ischemia
Vascular Remodeling
Intercellular Signaling Peptides and Proteins
Cell-and Tissue Based Therapy
description CNPq
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-15T17:43:44Z
dc.date.available.fl_str_mv 2016-12-15T17:43:44Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REBOUÇAS, J. S.; MAGALHÃES, N. S. S.; FORMIGA, F. R. Cardiac Regeneration using Growth Factors: Advances and Challenges. Arquivos Brasileiros de Cardiologia, v. 107, n. 3, p. 271-275, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16553
dc.identifier.issn.pt_BR.fl_str_mv 0066-782X
dc.identifier.doi.none.fl_str_mv 10.5935/abc.20160097
identifier_str_mv REBOUÇAS, J. S.; MAGALHÃES, N. S. S.; FORMIGA, F. R. Cardiac Regeneration using Growth Factors: Advances and Challenges. Arquivos Brasileiros de Cardiologia, v. 107, n. 3, p. 271-275, 2016.
0066-782X
10.5935/abc.20160097
url https://www.arca.fiocruz.br/handle/icict/16553
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/16553/1/license.txt
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