A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction

Detalhes bibliográficos
Autor(a) principal: Wang,Zhida
Data de Publicação: 2017
Outros Autores: Cai,Wang, Hu,Shaolan, Xia,Yufei, Wang,Yao, Zhang,Qi, Chen,Liming
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000800156
Resumo: Abstract Background: Cell-derived microvesicles (MVs) are vesicles released from activated or apoptotic cells. However, the levels of MVs in myocardial infarction have been found inconsistent in researches. Objective: To assess the association between MVs and myocardial infarction by conducting a meta-analysis. Methods: A systematic literature search on PubMed, Embase, Cochran, Google Scholar electronic database was conducted. Comparison of the MVs levels between myocardial infarction patients and healthy persons were included in our study. Standard Mean Difference (SMD) and 95% confidence interval (CI) in groups were calculated and meta-analyzed. Results: 11 studies with a total of 436 participants were included. Compared with the health persons, AMVs [SMD = 3.65, 95% CI (1.03, 6.27)], PMVs [SMD = 2.88, 95% CI (1.82, 3.93),] and EMVs [SMD = 2.73, 95% CI (1.13, 4.34)], levels were higher in patients with myocardial infarction. However, LMVs levels [SMD = 0.73, 95% CI (-0.57, 2.03)] were not changed significantly in patients with myocardial infarction. Conclusions: AMVs, PMVs and EMVs might be potential biomarkers for myocardial infarction.
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spelling A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial InfarctionMyocardiaol InfarctionBiomarkersCell-Derived MicroparticlesAnnexion A5Blood PlateletsLeukocytesEndotheliumAbstract Background: Cell-derived microvesicles (MVs) are vesicles released from activated or apoptotic cells. However, the levels of MVs in myocardial infarction have been found inconsistent in researches. Objective: To assess the association between MVs and myocardial infarction by conducting a meta-analysis. Methods: A systematic literature search on PubMed, Embase, Cochran, Google Scholar electronic database was conducted. Comparison of the MVs levels between myocardial infarction patients and healthy persons were included in our study. Standard Mean Difference (SMD) and 95% confidence interval (CI) in groups were calculated and meta-analyzed. Results: 11 studies with a total of 436 participants were included. Compared with the health persons, AMVs [SMD = 3.65, 95% CI (1.03, 6.27)], PMVs [SMD = 2.88, 95% CI (1.82, 3.93),] and EMVs [SMD = 2.73, 95% CI (1.13, 4.34)], levels were higher in patients with myocardial infarction. However, LMVs levels [SMD = 0.73, 95% CI (-0.57, 2.03)] were not changed significantly in patients with myocardial infarction. Conclusions: AMVs, PMVs and EMVs might be potential biomarkers for myocardial infarction.Sociedade Brasileira de Cardiologia - SBC2017-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000800156Arquivos Brasileiros de Cardiologia v.109 n.2 2017reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20170102info:eu-repo/semantics/openAccessWang,ZhidaCai,WangHu,ShaolanXia,YufeiWang,YaoZhang,QiChen,Limingeng2017-09-13T00:00:00Zoai:scielo:S0066-782X2017000800156Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2017-09-13T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction
title A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction
spellingShingle A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction
Wang,Zhida
Myocardiaol Infarction
Biomarkers
Cell-Derived Microparticles
Annexion A5
Blood Platelets
Leukocytes
Endothelium
title_short A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction
title_full A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction
title_fullStr A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction
title_full_unstemmed A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction
title_sort A Meta-Analysis of Circulating Microvesicles in Patients with Myocardial Infarction
author Wang,Zhida
author_facet Wang,Zhida
Cai,Wang
Hu,Shaolan
Xia,Yufei
Wang,Yao
Zhang,Qi
Chen,Liming
author_role author
author2 Cai,Wang
Hu,Shaolan
Xia,Yufei
Wang,Yao
Zhang,Qi
Chen,Liming
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Wang,Zhida
Cai,Wang
Hu,Shaolan
Xia,Yufei
Wang,Yao
Zhang,Qi
Chen,Liming
dc.subject.por.fl_str_mv Myocardiaol Infarction
Biomarkers
Cell-Derived Microparticles
Annexion A5
Blood Platelets
Leukocytes
Endothelium
topic Myocardiaol Infarction
Biomarkers
Cell-Derived Microparticles
Annexion A5
Blood Platelets
Leukocytes
Endothelium
description Abstract Background: Cell-derived microvesicles (MVs) are vesicles released from activated or apoptotic cells. However, the levels of MVs in myocardial infarction have been found inconsistent in researches. Objective: To assess the association between MVs and myocardial infarction by conducting a meta-analysis. Methods: A systematic literature search on PubMed, Embase, Cochran, Google Scholar electronic database was conducted. Comparison of the MVs levels between myocardial infarction patients and healthy persons were included in our study. Standard Mean Difference (SMD) and 95% confidence interval (CI) in groups were calculated and meta-analyzed. Results: 11 studies with a total of 436 participants were included. Compared with the health persons, AMVs [SMD = 3.65, 95% CI (1.03, 6.27)], PMVs [SMD = 2.88, 95% CI (1.82, 3.93),] and EMVs [SMD = 2.73, 95% CI (1.13, 4.34)], levels were higher in patients with myocardial infarction. However, LMVs levels [SMD = 0.73, 95% CI (-0.57, 2.03)] were not changed significantly in patients with myocardial infarction. Conclusions: AMVs, PMVs and EMVs might be potential biomarkers for myocardial infarction.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000800156
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000800156
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20170102
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.109 n.2 2017
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
instacron_str SBC
institution SBC
reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv ||arquivos@cardiol.br
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