Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction

Detalhes bibliográficos
Autor(a) principal: Winter,Simone de Campos Neitzke
Data de Publicação: 2018
Outros Autores: Macedo,Rafael Michel de, Francisco,Júlio Cesar, Santos,Paula Costa, Lopes,Ana Paula Sarraff, Meira,Leanderson Franco de, Carvalho,Katherine A. Teixeira de, Faria Neto,José Rocha, Macedo,Ana Carolina Brandt de, Guarita-Souza,Luiz César
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000400373
Resumo: Abstract Background: Physical exercise should be part of the treatment of post-acute myocardial infarction (AMI) patients. Objective: To evaluate the effects of two training prescription models (continuous x interval) and its impact on ventricular function in rats after AMI with normal ventricular function. Methods: Forty Wistar rats were evaluated by echocardiography 21 days after the AMI. Those with LVEF = 50% (n = 29) were included in the study and randomized to control group (CG n = 10), continuous training group (CTG n = 9) or interval training group (ITG, n = 10). Then, a swimming test with control of lactate production was performed. Based on its result, the lactate threshold (LT) was established to define the training intensities. After six weeks, the animals were reassessed by echocardiography and lactate production. Outcome measures were end-diastolic diameter (EDD), end-systolic diameter (ESD), left ventricular ejection fraction (LVEF, %) lactate at rest, lactate without overload, and lactate with 12g and 13.5g of additional load. Group comparisons of quantitative variables of the study were performed by one-factor analysis of variance (ANOVA). The Newman-Keuls test was used for multiple comparisons of the groups. Within-group comparisons of dependent variables between the two training protocols were performed by Student's t-test. Normality of the variables was tested by the Shapiro-Wilks test. Values of p < 0.05 indicated statistical significance. Results: EDD, ESD, and LVEF before and after the training period were similar in within-group comparisons. However, EDD was significantly different (p=0.008) in the CG. Significant differences were found for L12g (p=0.002) and L13.5g (p = 0.032) in the ITG, and for L12g (p = 0.014) in the CG. No differences were found in the echocardiographic parameters between the groups. Significant differences were found in lactate without overload (p = 0.016) and L12 (p = 0.031) in the second assessment compared with the first, and between the groups - ITG vs. CG (p = 0.019) and CTG vs. CG (p = 0.035). Conclusion: Both methods produced a training effect without altering ventricular function.
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spelling Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial InfarctionMyocardial InfarctionExerciseVentricular Function, LeftRatsAnaerobic ThresholdAbstract Background: Physical exercise should be part of the treatment of post-acute myocardial infarction (AMI) patients. Objective: To evaluate the effects of two training prescription models (continuous x interval) and its impact on ventricular function in rats after AMI with normal ventricular function. Methods: Forty Wistar rats were evaluated by echocardiography 21 days after the AMI. Those with LVEF = 50% (n = 29) were included in the study and randomized to control group (CG n = 10), continuous training group (CTG n = 9) or interval training group (ITG, n = 10). Then, a swimming test with control of lactate production was performed. Based on its result, the lactate threshold (LT) was established to define the training intensities. After six weeks, the animals were reassessed by echocardiography and lactate production. Outcome measures were end-diastolic diameter (EDD), end-systolic diameter (ESD), left ventricular ejection fraction (LVEF, %) lactate at rest, lactate without overload, and lactate with 12g and 13.5g of additional load. Group comparisons of quantitative variables of the study were performed by one-factor analysis of variance (ANOVA). The Newman-Keuls test was used for multiple comparisons of the groups. Within-group comparisons of dependent variables between the two training protocols were performed by Student's t-test. Normality of the variables was tested by the Shapiro-Wilks test. Values of p < 0.05 indicated statistical significance. Results: EDD, ESD, and LVEF before and after the training period were similar in within-group comparisons. However, EDD was significantly different (p=0.008) in the CG. Significant differences were found for L12g (p=0.002) and L13.5g (p = 0.032) in the ITG, and for L12g (p = 0.014) in the CG. No differences were found in the echocardiographic parameters between the groups. Significant differences were found in lactate without overload (p = 0.016) and L12 (p = 0.031) in the second assessment compared with the first, and between the groups - ITG vs. CG (p = 0.019) and CTG vs. CG (p = 0.035). Conclusion: Both methods produced a training effect without altering ventricular function.Sociedade Brasileira de Cardiologia - SBC2018-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000400373Arquivos Brasileiros de Cardiologia v.110 n.4 2018reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20180036info:eu-repo/semantics/openAccessWinter,Simone de Campos NeitzkeMacedo,Rafael Michel deFrancisco,Júlio CesarSantos,Paula CostaLopes,Ana Paula SarraffMeira,Leanderson Franco deCarvalho,Katherine A. Teixeira deFaria Neto,José RochaMacedo,Ana Carolina Brandt deGuarita-Souza,Luiz Césareng2018-05-17T00:00:00Zoai:scielo:S0066-782X2018000400373Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2018-05-17T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction
title Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction
spellingShingle Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction
Winter,Simone de Campos Neitzke
Myocardial Infarction
Exercise
Ventricular Function, Left
Rats
Anaerobic Threshold
title_short Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction
title_full Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction
title_fullStr Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction
title_full_unstemmed Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction
title_sort Impact of a High-Intensity Training on Ventricular Function in Rats After Acute Myocardial Infarction
author Winter,Simone de Campos Neitzke
author_facet Winter,Simone de Campos Neitzke
Macedo,Rafael Michel de
Francisco,Júlio Cesar
Santos,Paula Costa
Lopes,Ana Paula Sarraff
Meira,Leanderson Franco de
Carvalho,Katherine A. Teixeira de
Faria Neto,José Rocha
Macedo,Ana Carolina Brandt de
Guarita-Souza,Luiz César
author_role author
author2 Macedo,Rafael Michel de
Francisco,Júlio Cesar
Santos,Paula Costa
Lopes,Ana Paula Sarraff
Meira,Leanderson Franco de
Carvalho,Katherine A. Teixeira de
Faria Neto,José Rocha
Macedo,Ana Carolina Brandt de
Guarita-Souza,Luiz César
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Winter,Simone de Campos Neitzke
Macedo,Rafael Michel de
Francisco,Júlio Cesar
Santos,Paula Costa
Lopes,Ana Paula Sarraff
Meira,Leanderson Franco de
Carvalho,Katherine A. Teixeira de
Faria Neto,José Rocha
Macedo,Ana Carolina Brandt de
Guarita-Souza,Luiz César
dc.subject.por.fl_str_mv Myocardial Infarction
Exercise
Ventricular Function, Left
Rats
Anaerobic Threshold
topic Myocardial Infarction
Exercise
Ventricular Function, Left
Rats
Anaerobic Threshold
description Abstract Background: Physical exercise should be part of the treatment of post-acute myocardial infarction (AMI) patients. Objective: To evaluate the effects of two training prescription models (continuous x interval) and its impact on ventricular function in rats after AMI with normal ventricular function. Methods: Forty Wistar rats were evaluated by echocardiography 21 days after the AMI. Those with LVEF = 50% (n = 29) were included in the study and randomized to control group (CG n = 10), continuous training group (CTG n = 9) or interval training group (ITG, n = 10). Then, a swimming test with control of lactate production was performed. Based on its result, the lactate threshold (LT) was established to define the training intensities. After six weeks, the animals were reassessed by echocardiography and lactate production. Outcome measures were end-diastolic diameter (EDD), end-systolic diameter (ESD), left ventricular ejection fraction (LVEF, %) lactate at rest, lactate without overload, and lactate with 12g and 13.5g of additional load. Group comparisons of quantitative variables of the study were performed by one-factor analysis of variance (ANOVA). The Newman-Keuls test was used for multiple comparisons of the groups. Within-group comparisons of dependent variables between the two training protocols were performed by Student's t-test. Normality of the variables was tested by the Shapiro-Wilks test. Values of p < 0.05 indicated statistical significance. Results: EDD, ESD, and LVEF before and after the training period were similar in within-group comparisons. However, EDD was significantly different (p=0.008) in the CG. Significant differences were found for L12g (p=0.002) and L13.5g (p = 0.032) in the ITG, and for L12g (p = 0.014) in the CG. No differences were found in the echocardiographic parameters between the groups. Significant differences were found in lactate without overload (p = 0.016) and L12 (p = 0.031) in the second assessment compared with the first, and between the groups - ITG vs. CG (p = 0.019) and CTG vs. CG (p = 0.035). Conclusion: Both methods produced a training effect without altering ventricular function.
publishDate 2018
dc.date.none.fl_str_mv 2018-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000400373
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20180036
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.110 n.4 2018
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
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instname_str Sociedade Brasileira de Cardiologia (SBC)
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reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv ||arquivos@cardiol.br
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