Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience

Detalhes bibliográficos
Autor(a) principal: Bouabdallaoui,Nadia
Data de Publicação: 2018
Outros Autores: Demondion,Pierre, Maréchaux,Sylvestre, Varnous,Shaida, Lebreton,Guillaume, Mouquet,Frédéric, Leprince,Pascal
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Cardiologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000200181
Resumo: Abstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p < 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values > 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p > 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment.
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spelling Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center ExperienceHeart FailureCardiomyopathies / mortalityPeripartum PeriodHeart TransplantationGraft Rejection. / mortalityAbstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p < 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values > 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p > 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment.Sociedade Brasileira de Cardiologia - SBC2018-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000200181Arquivos Brasileiros de Cardiologia v.110 n.2 2018reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20180014info:eu-repo/semantics/openAccessBouabdallaoui,NadiaDemondion,PierreMaréchaux,SylvestreVarnous,ShaidaLebreton,GuillaumeMouquet,FrédéricLeprince,Pascaleng2018-03-16T00:00:00Zoai:scielo:S0066-782X2018000200181Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2018-03-16T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience
title Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience
spellingShingle Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience
Bouabdallaoui,Nadia
Heart Failure
Cardiomyopathies / mortality
Peripartum Period
Heart Transplantation
Graft Rejection. / mortality
title_short Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience
title_full Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience
title_fullStr Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience
title_full_unstemmed Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience
title_sort Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience
author Bouabdallaoui,Nadia
author_facet Bouabdallaoui,Nadia
Demondion,Pierre
Maréchaux,Sylvestre
Varnous,Shaida
Lebreton,Guillaume
Mouquet,Frédéric
Leprince,Pascal
author_role author
author2 Demondion,Pierre
Maréchaux,Sylvestre
Varnous,Shaida
Lebreton,Guillaume
Mouquet,Frédéric
Leprince,Pascal
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bouabdallaoui,Nadia
Demondion,Pierre
Maréchaux,Sylvestre
Varnous,Shaida
Lebreton,Guillaume
Mouquet,Frédéric
Leprince,Pascal
dc.subject.por.fl_str_mv Heart Failure
Cardiomyopathies / mortality
Peripartum Period
Heart Transplantation
Graft Rejection. / mortality
topic Heart Failure
Cardiomyopathies / mortality
Peripartum Period
Heart Transplantation
Graft Rejection. / mortality
description Abstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p < 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values > 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p > 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000200181
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/abc.20180014
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv Arquivos Brasileiros de Cardiologia v.110 n.2 2018
reponame:Arquivos Brasileiros de Cardiologia (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
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instname_str Sociedade Brasileira de Cardiologia (SBC)
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reponame_str Arquivos Brasileiros de Cardiologia (Online)
collection Arquivos Brasileiros de Cardiologia (Online)
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