Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Cardiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000200181 |
Resumo: | Abstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p < 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values > 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p > 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment. |
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Arquivos Brasileiros de Cardiologia (Online) |
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Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center ExperienceHeart FailureCardiomyopathies / mortalityPeripartum PeriodHeart TransplantationGraft Rejection. / mortalityAbstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p < 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values > 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p > 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment.Sociedade Brasileira de Cardiologia - SBC2018-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000200181Arquivos Brasileiros de Cardiologia v.110 n.2 2018reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20180014info:eu-repo/semantics/openAccessBouabdallaoui,NadiaDemondion,PierreMaréchaux,SylvestreVarnous,ShaidaLebreton,GuillaumeMouquet,FrédéricLeprince,Pascaleng2018-03-16T00:00:00Zoai:scielo:S0066-782X2018000200181Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2018-03-16T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience |
title |
Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience |
spellingShingle |
Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience Bouabdallaoui,Nadia Heart Failure Cardiomyopathies / mortality Peripartum Period Heart Transplantation Graft Rejection. / mortality |
title_short |
Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience |
title_full |
Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience |
title_fullStr |
Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience |
title_full_unstemmed |
Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience |
title_sort |
Heart Transplantation for Peripartum Cardiomyopathy: A Single-Center Experience |
author |
Bouabdallaoui,Nadia |
author_facet |
Bouabdallaoui,Nadia Demondion,Pierre Maréchaux,Sylvestre Varnous,Shaida Lebreton,Guillaume Mouquet,Frédéric Leprince,Pascal |
author_role |
author |
author2 |
Demondion,Pierre Maréchaux,Sylvestre Varnous,Shaida Lebreton,Guillaume Mouquet,Frédéric Leprince,Pascal |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Bouabdallaoui,Nadia Demondion,Pierre Maréchaux,Sylvestre Varnous,Shaida Lebreton,Guillaume Mouquet,Frédéric Leprince,Pascal |
dc.subject.por.fl_str_mv |
Heart Failure Cardiomyopathies / mortality Peripartum Period Heart Transplantation Graft Rejection. / mortality |
topic |
Heart Failure Cardiomyopathies / mortality Peripartum Period Heart Transplantation Graft Rejection. / mortality |
description |
Abstract Background: Peripartum cardiomyopathy is an idiopathic disorder defined by the occurrence of acute heart failure during late pregnancy or post-partum period in the absence of any other definable cause. Its clinical course is variable and severe cases might require heart transplantation. Objective: To investigate long-term outcomes after heart transplantation (HT) for peripartum cardiomyopathy (PPCM). Methods: Out of a single-center series of 1938 HT, 14 HT were performed for PPCM. We evaluated clinical characteristics, transplant-related complications, and long-term outcomes, in comparison with 28 sex-matched controls. Primary endpoint was death from any cause; secondary endpoints were transplant-related complications (rejection, infection, cardiac allograft vasculopathy). A value of p < 0.05 was considered of statistical significance. Results: PPCM patients and matched controls were comparable for most variables (all p values > 0.05), except for a higher use of inotropes at the time of HT in PPCM group (p = 0.03). During a median follow-up of 7.7 years, 16 patients died, 3 (21.5%) in PPCM group and 13 (46.5%) in control group. Mortality was significantly lower in PPCM group (p = 0.03). No significant difference was found in terms of transplant-related complications (p > 0.05). Conclusions: Long-term outcomes following HT for PPCM are favorable. Heart transplantation is a valuable option for PPCM patients who did not recover significantly under medical treatment. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000200181 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018000200181 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/abc.20180014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia v.110 n.2 2018 reponame:Arquivos Brasileiros de Cardiologia (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
Arquivos Brasileiros de Cardiologia (Online) |
collection |
Arquivos Brasileiros de Cardiologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
||arquivos@cardiol.br |
_version_ |
1752126568668332032 |