Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian Syndrome

Detalhes bibliográficos
Autor(a) principal: Burlá,Marcelo
Data de Publicação: 2019
Outros Autores: Cunha,Ana Rosa, Gismondi,Ronaldo, Oigman,Wille, Neves,Mario Fritsch, Medeiros,Fernanda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: International Journal of Cardiovascular Sciences (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472019000100003
Resumo: Abstract Background: Patients with polycystic ovarian syndrome (PCOS) have an increased prevalence of metabolic syndrome and traditional atherosclerotic risk factors, such as dyslipidemia, diabetes and hypertension. Endothelial function and vascular stiffness are surrogate markers of early atherosclerosis, able to predict cardiovascular events. Objective: To compare endothelial function and pulse wave reflection between women with PCOS and healthy controls. Methods: Observational and cross-sectional study that included women with PCOS, age between 18 and 40 years-old and body mass index between 25.0 and 35.0 kg/m2, and healthy controls. Rotterdan criteria was used to diagnose PCOS. Subjects underwent clinical and anthropometric evaluation, laboratory and hormonal assays and imaging tests to measure pulse wave velocity (PWV), augmentation index (AIx) and brachial artery flow-mediated vasodilation (FMD). Kolmogorov-Smirnov test showed normal distribution of most parameters. Unpaired Student t-test was used with significance level established at p < 0.05. Results: A total of 52 patients were included, 29 (56%) in PCOS group and 23 (44%) in control group. Clinical and laboratory parameters were similar between the groups. Women with PCOS had lower FMD (8.8 ± 1.0 vs 12.8 ± 1.2%, p = 0.021); PWV and AIx were similar between the groups (7.5 ± 0.2 vs 7.5 ± 0.3 m/s, p = 0.671 and 21.0 ± 1 vs. 20 ± 2%, p = 0.716, respectively). In the PCOS group, women with higher testosterone levels had higher AIx (25 ± 2 vs. 17 ± 3%, p = 0.045). Conclusions: PCOS women had endothelial dysfunction and those with higher testosterone levels had higher pulse wave reflection as compared with controls.
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spelling Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian SyndromeEndothelium, VascularVascular,StiffnessMetabolic SyndromePolycistic Ovary SyndromeInsulin ResistanceTestosteroneAbstract Background: Patients with polycystic ovarian syndrome (PCOS) have an increased prevalence of metabolic syndrome and traditional atherosclerotic risk factors, such as dyslipidemia, diabetes and hypertension. Endothelial function and vascular stiffness are surrogate markers of early atherosclerosis, able to predict cardiovascular events. Objective: To compare endothelial function and pulse wave reflection between women with PCOS and healthy controls. Methods: Observational and cross-sectional study that included women with PCOS, age between 18 and 40 years-old and body mass index between 25.0 and 35.0 kg/m2, and healthy controls. Rotterdan criteria was used to diagnose PCOS. Subjects underwent clinical and anthropometric evaluation, laboratory and hormonal assays and imaging tests to measure pulse wave velocity (PWV), augmentation index (AIx) and brachial artery flow-mediated vasodilation (FMD). Kolmogorov-Smirnov test showed normal distribution of most parameters. Unpaired Student t-test was used with significance level established at p < 0.05. Results: A total of 52 patients were included, 29 (56%) in PCOS group and 23 (44%) in control group. Clinical and laboratory parameters were similar between the groups. Women with PCOS had lower FMD (8.8 ± 1.0 vs 12.8 ± 1.2%, p = 0.021); PWV and AIx were similar between the groups (7.5 ± 0.2 vs 7.5 ± 0.3 m/s, p = 0.671 and 21.0 ± 1 vs. 20 ± 2%, p = 0.716, respectively). In the PCOS group, women with higher testosterone levels had higher AIx (25 ± 2 vs. 17 ± 3%, p = 0.045). Conclusions: PCOS women had endothelial dysfunction and those with higher testosterone levels had higher pulse wave reflection as compared with controls.Sociedade Brasileira de Cardiologia2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472019000100003International Journal of Cardiovascular Sciences v.32 n.1 2019reponame:International Journal of Cardiovascular Sciences (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/2359-4802.20180067info:eu-repo/semantics/openAccessBurlá,MarceloCunha,Ana RosaGismondi,RonaldoOigman,WilleNeves,Mario FritschMedeiros,Fernandaeng2019-01-21T00:00:00Zoai:scielo:S2359-56472019000100003Revistahttp://publicacoes.cardiol.br/portal/ijcshttps://old.scielo.br/oai/scielo-oai.phptailanerodrigues@cardiol.br||revistaijcs@cardiol.br2359-56472359-4802opendoar:2019-01-21T00:00International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)false
dc.title.none.fl_str_mv Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian Syndrome
title Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian Syndrome
spellingShingle Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian Syndrome
Burlá,Marcelo
Endothelium, Vascular
Vascular,Stiffness
Metabolic Syndrome
Polycistic Ovary Syndrome
Insulin Resistance
Testosterone
title_short Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian Syndrome
title_full Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian Syndrome
title_fullStr Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian Syndrome
title_full_unstemmed Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian Syndrome
title_sort Endothelial Dysfunction and Pulse Wave Reflection in Women with Polycystic Ovarian Syndrome
author Burlá,Marcelo
author_facet Burlá,Marcelo
Cunha,Ana Rosa
Gismondi,Ronaldo
Oigman,Wille
Neves,Mario Fritsch
Medeiros,Fernanda
author_role author
author2 Cunha,Ana Rosa
Gismondi,Ronaldo
Oigman,Wille
Neves,Mario Fritsch
Medeiros,Fernanda
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Burlá,Marcelo
Cunha,Ana Rosa
Gismondi,Ronaldo
Oigman,Wille
Neves,Mario Fritsch
Medeiros,Fernanda
dc.subject.por.fl_str_mv Endothelium, Vascular
Vascular,Stiffness
Metabolic Syndrome
Polycistic Ovary Syndrome
Insulin Resistance
Testosterone
topic Endothelium, Vascular
Vascular,Stiffness
Metabolic Syndrome
Polycistic Ovary Syndrome
Insulin Resistance
Testosterone
description Abstract Background: Patients with polycystic ovarian syndrome (PCOS) have an increased prevalence of metabolic syndrome and traditional atherosclerotic risk factors, such as dyslipidemia, diabetes and hypertension. Endothelial function and vascular stiffness are surrogate markers of early atherosclerosis, able to predict cardiovascular events. Objective: To compare endothelial function and pulse wave reflection between women with PCOS and healthy controls. Methods: Observational and cross-sectional study that included women with PCOS, age between 18 and 40 years-old and body mass index between 25.0 and 35.0 kg/m2, and healthy controls. Rotterdan criteria was used to diagnose PCOS. Subjects underwent clinical and anthropometric evaluation, laboratory and hormonal assays and imaging tests to measure pulse wave velocity (PWV), augmentation index (AIx) and brachial artery flow-mediated vasodilation (FMD). Kolmogorov-Smirnov test showed normal distribution of most parameters. Unpaired Student t-test was used with significance level established at p < 0.05. Results: A total of 52 patients were included, 29 (56%) in PCOS group and 23 (44%) in control group. Clinical and laboratory parameters were similar between the groups. Women with PCOS had lower FMD (8.8 ± 1.0 vs 12.8 ± 1.2%, p = 0.021); PWV and AIx were similar between the groups (7.5 ± 0.2 vs 7.5 ± 0.3 m/s, p = 0.671 and 21.0 ± 1 vs. 20 ± 2%, p = 0.716, respectively). In the PCOS group, women with higher testosterone levels had higher AIx (25 ± 2 vs. 17 ± 3%, p = 0.045). Conclusions: PCOS women had endothelial dysfunction and those with higher testosterone levels had higher pulse wave reflection as compared with controls.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472019000100003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472019000100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/2359-4802.20180067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia
dc.source.none.fl_str_mv International Journal of Cardiovascular Sciences v.32 n.1 2019
reponame:International Journal of Cardiovascular Sciences (Online)
instname:Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
instname_str Sociedade Brasileira de Cardiologia (SBC)
instacron_str SBC
institution SBC
reponame_str International Journal of Cardiovascular Sciences (Online)
collection International Journal of Cardiovascular Sciences (Online)
repository.name.fl_str_mv International Journal of Cardiovascular Sciences (Online) - Sociedade Brasileira de Cardiologia (SBC)
repository.mail.fl_str_mv tailanerodrigues@cardiol.br||revistaijcs@cardiol.br
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