GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW

Detalhes bibliográficos
Autor(a) principal: TELES FILHO,RICARDO VIEIRA
Data de Publicação: 2019
Outros Autores: ABE,GUILHERME DE MATOS, MELO,NILO CARRIJO, RABAHI,MARCELO FOUAD, DAHER,MURILO TAVARES
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Coluna/Columna
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512019000300236
Resumo: ABSTRACT The idiopathic scoliosis (IS) is the most common form of spinal deformity. The pathogenesis of IS is still poorly understood. Several studies show evidence that the genetic component is determinant to the development of IS. In this setting, a crescent focus has been placed on the identification of genes, associated genetic polymorphisms, and multiple susceptibility loci. This review highlights the genes and genetic polymorphisms currently studied, identified as influential in the genesis of IS, such as MMP-3, IL-6, type I collagen, and vitamin D and estrogen receptors. We concluded that IS remains a complex disease with a polygenic background and that genetic polymorphisms are intrinsically related to this condition. Level of evidence III; Narrative Review.
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spelling GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEWAdolescentScoliosisSpineGeneticsPolymorphism, GeneticABSTRACT The idiopathic scoliosis (IS) is the most common form of spinal deformity. The pathogenesis of IS is still poorly understood. Several studies show evidence that the genetic component is determinant to the development of IS. In this setting, a crescent focus has been placed on the identification of genes, associated genetic polymorphisms, and multiple susceptibility loci. This review highlights the genes and genetic polymorphisms currently studied, identified as influential in the genesis of IS, such as MMP-3, IL-6, type I collagen, and vitamin D and estrogen receptors. We concluded that IS remains a complex disease with a polygenic background and that genetic polymorphisms are intrinsically related to this condition. Level of evidence III; Narrative Review.Sociedade Brasileira de Coluna2019-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512019000300236Coluna/Columna v.18 n.3 2019reponame:Coluna/Columnainstname:Sociedade Brasileira de Coluna (SBCO)instacron:SBCO10.1590/s1808-185120191803212974info:eu-repo/semantics/openAccessTELES FILHO,RICARDO VIEIRAABE,GUILHERME DE MATOSMELO,NILO CARRIJORABAHI,MARCELO FOUADDAHER,MURILO TAVARESeng2019-08-28T00:00:00Zoai:scielo:S1808-18512019000300236Revistahttps://www.revistacoluna.org/ONGhttps://old.scielo.br/oai/scielo-oai.phpcoluna.columna@uol.com.br||revistacoluna@uol.com.br2177-014X1808-1851opendoar:2019-08-28T00:00Coluna/Columna - Sociedade Brasileira de Coluna (SBCO)false
dc.title.none.fl_str_mv GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW
title GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW
spellingShingle GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW
TELES FILHO,RICARDO VIEIRA
Adolescent
Scoliosis
Spine
Genetics
Polymorphism, Genetic
title_short GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW
title_full GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW
title_fullStr GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW
title_full_unstemmed GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW
title_sort GENETIC ASPECTS OF IDIOPATHIC ESCOLIOSIS - A LITERATURE REVIEW
author TELES FILHO,RICARDO VIEIRA
author_facet TELES FILHO,RICARDO VIEIRA
ABE,GUILHERME DE MATOS
MELO,NILO CARRIJO
RABAHI,MARCELO FOUAD
DAHER,MURILO TAVARES
author_role author
author2 ABE,GUILHERME DE MATOS
MELO,NILO CARRIJO
RABAHI,MARCELO FOUAD
DAHER,MURILO TAVARES
author2_role author
author
author
author
dc.contributor.author.fl_str_mv TELES FILHO,RICARDO VIEIRA
ABE,GUILHERME DE MATOS
MELO,NILO CARRIJO
RABAHI,MARCELO FOUAD
DAHER,MURILO TAVARES
dc.subject.por.fl_str_mv Adolescent
Scoliosis
Spine
Genetics
Polymorphism, Genetic
topic Adolescent
Scoliosis
Spine
Genetics
Polymorphism, Genetic
description ABSTRACT The idiopathic scoliosis (IS) is the most common form of spinal deformity. The pathogenesis of IS is still poorly understood. Several studies show evidence that the genetic component is determinant to the development of IS. In this setting, a crescent focus has been placed on the identification of genes, associated genetic polymorphisms, and multiple susceptibility loci. This review highlights the genes and genetic polymorphisms currently studied, identified as influential in the genesis of IS, such as MMP-3, IL-6, type I collagen, and vitamin D and estrogen receptors. We concluded that IS remains a complex disease with a polygenic background and that genetic polymorphisms are intrinsically related to this condition. Level of evidence III; Narrative Review.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512019000300236
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512019000300236
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s1808-185120191803212974
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Coluna
publisher.none.fl_str_mv Sociedade Brasileira de Coluna
dc.source.none.fl_str_mv Coluna/Columna v.18 n.3 2019
reponame:Coluna/Columna
instname:Sociedade Brasileira de Coluna (SBCO)
instacron:SBCO
instname_str Sociedade Brasileira de Coluna (SBCO)
instacron_str SBCO
institution SBCO
reponame_str Coluna/Columna
collection Coluna/Columna
repository.name.fl_str_mv Coluna/Columna - Sociedade Brasileira de Coluna (SBCO)
repository.mail.fl_str_mv coluna.columna@uol.com.br||revistacoluna@uol.com.br
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