DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Coluna/Columna |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000200145 |
Resumo: | ABSTRACT Objective: To determine the amount of loss of function after spinal cord transection of varying extents, and whether magnetic iron oxide nanoparticles, in combination with an external magnetic field, improve the rate of subsequent functional recovery in rats. Methods: The animals were divided into groups with 50%, 80% and complete spinal cord transection. The animals of all three study groups were administered magnetic iron oxide nanoparticle suspension to the area of injury. The three control groups were not administered magnetic nanoparticles, but had corresponding transection levels. All animals were exposed to a magnetic field for 4 weeks. Loss of postoperative function and subsequent recovery were assessed using the BBB motor function scale and somatosensory evoked potential monitoring on the first day after surgery, and then weekly. Terminal histological analysis was also conducted in all the groups. Results: The animals in the control or complete transection groups did not demonstrate statistically significant improvement in either the BBB scores or evoked potential amplitude over the four-week period. In the group with 50% transection, however, a statistically significant increase in evoked potential amplitude and BBB scores was observed four weeks after surgery, with the highest increase during the second week of the study. In the group with 80% transection, only improvement in evoked potential amplitude was statistically significant, although less pronounced than in the 50% transection group. Conclusion: The use of magnetic iron oxide nanoparticles in combination with a magnetic field leads to higher rates of functional recovery after spinal cord injury in laboratory animals. The mechanism of this functional improvement needs further investigation. |
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DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELDSpinal cord injuriesMagnetite nanoparticlesMagnetic field therapyRats, Wistar.ABSTRACT Objective: To determine the amount of loss of function after spinal cord transection of varying extents, and whether magnetic iron oxide nanoparticles, in combination with an external magnetic field, improve the rate of subsequent functional recovery in rats. Methods: The animals were divided into groups with 50%, 80% and complete spinal cord transection. The animals of all three study groups were administered magnetic iron oxide nanoparticle suspension to the area of injury. The three control groups were not administered magnetic nanoparticles, but had corresponding transection levels. All animals were exposed to a magnetic field for 4 weeks. Loss of postoperative function and subsequent recovery were assessed using the BBB motor function scale and somatosensory evoked potential monitoring on the first day after surgery, and then weekly. Terminal histological analysis was also conducted in all the groups. Results: The animals in the control or complete transection groups did not demonstrate statistically significant improvement in either the BBB scores or evoked potential amplitude over the four-week period. In the group with 50% transection, however, a statistically significant increase in evoked potential amplitude and BBB scores was observed four weeks after surgery, with the highest increase during the second week of the study. In the group with 80% transection, only improvement in evoked potential amplitude was statistically significant, although less pronounced than in the 50% transection group. Conclusion: The use of magnetic iron oxide nanoparticles in combination with a magnetic field leads to higher rates of functional recovery after spinal cord injury in laboratory animals. The mechanism of this functional improvement needs further investigation.Sociedade Brasileira de Coluna2017-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000200145Coluna/Columna v.16 n.2 2017reponame:Coluna/Columnainstname:Sociedade Brasileira de Coluna (SBCO)instacron:SBCO10.1590/s1808-185120171602172206info:eu-repo/semantics/openAccessKolesov,SergeyPanteleyev,AndreySazhnev,MaximKazmin,Arkadiyeng2017-06-21T00:00:00Zoai:scielo:S1808-18512017000200145Revistahttps://www.revistacoluna.org/ONGhttps://old.scielo.br/oai/scielo-oai.phpcoluna.columna@uol.com.br||revistacoluna@uol.com.br2177-014X1808-1851opendoar:2017-06-21T00:00Coluna/Columna - Sociedade Brasileira de Coluna (SBCO)false |
dc.title.none.fl_str_mv |
DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD |
title |
DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD |
spellingShingle |
DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD Kolesov,Sergey Spinal cord injuries Magnetite nanoparticles Magnetic field therapy Rats, Wistar. |
title_short |
DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD |
title_full |
DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD |
title_fullStr |
DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD |
title_full_unstemmed |
DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD |
title_sort |
DEVELOPING NEW METHODS OF SPINAL CORD INJURY TREATMENT USING MAGNETIC NANOPARTICLES IN COMBINATION WITH ELECTROMAGNETIC FIELD |
author |
Kolesov,Sergey |
author_facet |
Kolesov,Sergey Panteleyev,Andrey Sazhnev,Maxim Kazmin,Arkadiy |
author_role |
author |
author2 |
Panteleyev,Andrey Sazhnev,Maxim Kazmin,Arkadiy |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Kolesov,Sergey Panteleyev,Andrey Sazhnev,Maxim Kazmin,Arkadiy |
dc.subject.por.fl_str_mv |
Spinal cord injuries Magnetite nanoparticles Magnetic field therapy Rats, Wistar. |
topic |
Spinal cord injuries Magnetite nanoparticles Magnetic field therapy Rats, Wistar. |
description |
ABSTRACT Objective: To determine the amount of loss of function after spinal cord transection of varying extents, and whether magnetic iron oxide nanoparticles, in combination with an external magnetic field, improve the rate of subsequent functional recovery in rats. Methods: The animals were divided into groups with 50%, 80% and complete spinal cord transection. The animals of all three study groups were administered magnetic iron oxide nanoparticle suspension to the area of injury. The three control groups were not administered magnetic nanoparticles, but had corresponding transection levels. All animals were exposed to a magnetic field for 4 weeks. Loss of postoperative function and subsequent recovery were assessed using the BBB motor function scale and somatosensory evoked potential monitoring on the first day after surgery, and then weekly. Terminal histological analysis was also conducted in all the groups. Results: The animals in the control or complete transection groups did not demonstrate statistically significant improvement in either the BBB scores or evoked potential amplitude over the four-week period. In the group with 50% transection, however, a statistically significant increase in evoked potential amplitude and BBB scores was observed four weeks after surgery, with the highest increase during the second week of the study. In the group with 80% transection, only improvement in evoked potential amplitude was statistically significant, although less pronounced than in the 50% transection group. Conclusion: The use of magnetic iron oxide nanoparticles in combination with a magnetic field leads to higher rates of functional recovery after spinal cord injury in laboratory animals. The mechanism of this functional improvement needs further investigation. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000200145 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000200145 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1808-185120171602172206 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Coluna |
publisher.none.fl_str_mv |
Sociedade Brasileira de Coluna |
dc.source.none.fl_str_mv |
Coluna/Columna v.16 n.2 2017 reponame:Coluna/Columna instname:Sociedade Brasileira de Coluna (SBCO) instacron:SBCO |
instname_str |
Sociedade Brasileira de Coluna (SBCO) |
instacron_str |
SBCO |
institution |
SBCO |
reponame_str |
Coluna/Columna |
collection |
Coluna/Columna |
repository.name.fl_str_mv |
Coluna/Columna - Sociedade Brasileira de Coluna (SBCO) |
repository.mail.fl_str_mv |
coluna.columna@uol.com.br||revistacoluna@uol.com.br |
_version_ |
1752126615542824960 |