Neoadjuvant radiotherapy in stage I cancer of the lower rectum
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of Coloproctology (Rio de Janeiro. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632016000100004 |
Resumo: | ABSTRACT INTRODUCTION: The mortality rate in low rectal cancer is related to pelvic and distant recurrence. For stage I tumors, local excision has being used increasingly, but recent studies show the need for caution with the use of this technique, as they do not consider the possibility of a positive node in stage I rectal tumors. Therefore, preoperative radiotherapy should be considered for early tumors, as an attempt to prevent recurrence. OBJECTIVE: Show the effectiveness of neoadjuvant radiotherapy in stage I cancer of the lower rectum of a cohort population. MATERIAL AND METHOD: A cohort study in a prospective database was made with a total of 538 patients, of which were considered 75 patients with stage I lower rectal cancer. Preoperative radiotherapy was performed and patients were followed up for a minimum period of five years. RESULTS: Stage I/TI group had 27 patients. All of them presented complete response to the treatment and did not need to be operated. During the follow up time of five years, this group showed no recurrence rate. The stage I/TII group had 48 patients. During the follow up, 8 patients had to be operated due to suspicious lesion or scar. They were submitted to full total local excision. After evaluating the pathological specimen, none of them proved to be adenocarcinoma. CONCLUSION: Preoperative radiation, not only reduced the local recurrence and mortality rate in lower rectal cancer, but also reduced the need for surgery in patients with stage I cancer. |
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Neoadjuvant radiotherapy in stage I cancer of the lower rectumRectal neoplasmsRadiotherapyMortalityIrradiationABSTRACT INTRODUCTION: The mortality rate in low rectal cancer is related to pelvic and distant recurrence. For stage I tumors, local excision has being used increasingly, but recent studies show the need for caution with the use of this technique, as they do not consider the possibility of a positive node in stage I rectal tumors. Therefore, preoperative radiotherapy should be considered for early tumors, as an attempt to prevent recurrence. OBJECTIVE: Show the effectiveness of neoadjuvant radiotherapy in stage I cancer of the lower rectum of a cohort population. MATERIAL AND METHOD: A cohort study in a prospective database was made with a total of 538 patients, of which were considered 75 patients with stage I lower rectal cancer. Preoperative radiotherapy was performed and patients were followed up for a minimum period of five years. RESULTS: Stage I/TI group had 27 patients. All of them presented complete response to the treatment and did not need to be operated. During the follow up time of five years, this group showed no recurrence rate. The stage I/TII group had 48 patients. During the follow up, 8 patients had to be operated due to suspicious lesion or scar. They were submitted to full total local excision. After evaluating the pathological specimen, none of them proved to be adenocarcinoma. CONCLUSION: Preoperative radiation, not only reduced the local recurrence and mortality rate in lower rectal cancer, but also reduced the need for surgery in patients with stage I cancer.Sociedade Brasileira de Coloproctologia2016-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632016000100004Journal of Coloproctology (Rio de Janeiro) v.36 n.1 2016reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1016/j.jcol.2015.12.001info:eu-repo/semantics/openAccessReis Neto,José Alfredo dosReis Junior,José Alfredo dosKagohara,Odorino HideyoshiSimões Neto,JoaquimBanci,Sergio OlivaOliveira,Luciane HianeEspinoza,Gustavo Alejandro GutierrezAlves Júnior,Antonio José Tiburcioeng2016-04-25T00:00:00Zoai:scielo:S2237-93632016000100004Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2016-04-25T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false |
dc.title.none.fl_str_mv |
Neoadjuvant radiotherapy in stage I cancer of the lower rectum |
title |
Neoadjuvant radiotherapy in stage I cancer of the lower rectum |
spellingShingle |
Neoadjuvant radiotherapy in stage I cancer of the lower rectum Reis Neto,José Alfredo dos Rectal neoplasms Radiotherapy Mortality Irradiation |
title_short |
Neoadjuvant radiotherapy in stage I cancer of the lower rectum |
title_full |
Neoadjuvant radiotherapy in stage I cancer of the lower rectum |
title_fullStr |
Neoadjuvant radiotherapy in stage I cancer of the lower rectum |
title_full_unstemmed |
Neoadjuvant radiotherapy in stage I cancer of the lower rectum |
title_sort |
Neoadjuvant radiotherapy in stage I cancer of the lower rectum |
author |
Reis Neto,José Alfredo dos |
author_facet |
Reis Neto,José Alfredo dos Reis Junior,José Alfredo dos Kagohara,Odorino Hideyoshi Simões Neto,Joaquim Banci,Sergio Oliva Oliveira,Luciane Hiane Espinoza,Gustavo Alejandro Gutierrez Alves Júnior,Antonio José Tiburcio |
author_role |
author |
author2 |
Reis Junior,José Alfredo dos Kagohara,Odorino Hideyoshi Simões Neto,Joaquim Banci,Sergio Oliva Oliveira,Luciane Hiane Espinoza,Gustavo Alejandro Gutierrez Alves Júnior,Antonio José Tiburcio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Reis Neto,José Alfredo dos Reis Junior,José Alfredo dos Kagohara,Odorino Hideyoshi Simões Neto,Joaquim Banci,Sergio Oliva Oliveira,Luciane Hiane Espinoza,Gustavo Alejandro Gutierrez Alves Júnior,Antonio José Tiburcio |
dc.subject.por.fl_str_mv |
Rectal neoplasms Radiotherapy Mortality Irradiation |
topic |
Rectal neoplasms Radiotherapy Mortality Irradiation |
description |
ABSTRACT INTRODUCTION: The mortality rate in low rectal cancer is related to pelvic and distant recurrence. For stage I tumors, local excision has being used increasingly, but recent studies show the need for caution with the use of this technique, as they do not consider the possibility of a positive node in stage I rectal tumors. Therefore, preoperative radiotherapy should be considered for early tumors, as an attempt to prevent recurrence. OBJECTIVE: Show the effectiveness of neoadjuvant radiotherapy in stage I cancer of the lower rectum of a cohort population. MATERIAL AND METHOD: A cohort study in a prospective database was made with a total of 538 patients, of which were considered 75 patients with stage I lower rectal cancer. Preoperative radiotherapy was performed and patients were followed up for a minimum period of five years. RESULTS: Stage I/TI group had 27 patients. All of them presented complete response to the treatment and did not need to be operated. During the follow up time of five years, this group showed no recurrence rate. The stage I/TII group had 48 patients. During the follow up, 8 patients had to be operated due to suspicious lesion or scar. They were submitted to full total local excision. After evaluating the pathological specimen, none of them proved to be adenocarcinoma. CONCLUSION: Preoperative radiation, not only reduced the local recurrence and mortality rate in lower rectal cancer, but also reduced the need for surgery in patients with stage I cancer. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632016000100004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632016000100004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jcol.2015.12.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Coloproctologia |
dc.source.none.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro) v.36 n.1 2016 reponame:Journal of Coloproctology (Rio de Janeiro. Online) instname:Sociedade Brasileira de Coloproctologia (SBCP) instacron:SBCP |
instname_str |
Sociedade Brasileira de Coloproctologia (SBCP) |
instacron_str |
SBCP |
institution |
SBCP |
reponame_str |
Journal of Coloproctology (Rio de Janeiro. Online) |
collection |
Journal of Coloproctology (Rio de Janeiro. Online) |
repository.name.fl_str_mv |
Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP) |
repository.mail.fl_str_mv |
||sbcp@sbcp.org.br |
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1752126477817610240 |