Effect of postconditioning and atorvastatin in preventing remote intestinal reperfusion injury

• Autor(a) principal: Santos,Carlos Henrique Marques dos
• Data de Publicação: 2017
• Outros Autores: Dourado,Doroty Mesquita, Sampaio,Trícia Luna, Dias,Letícia do Espirito Santo, Almeida,Murillo Henrique Martins de, Oliva,João Victor Durães Gomes, Chaves,Ian de Oliveira, Pontes,Henrique Budib Dorsa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of Coloproctology (Rio de Janeiro. Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632017000400301
• topic: Ischemia; Reperfusion; Ischemic postconditioning; Hydroxymethylglutaryl-CoA reductase inhibitors; Small intestine

ABSTRACT Objective: To evaluate the capacity of ischemic postconditioning and atorvastatin in prevent or minimize reperfusion injury in small bowel of rats subjected to ischemia and reperfusion by abdominal aorta clamping. Methods: 41 Wistar norvegic rats were distributed into 5 groups: ischemia and reperfusion, ischemic postconditioning, postconditioning + statin, statin and Sham. After anesthesia, laparotomy and dissection of the infra-renal abdominal aorta were performed; except the Sham group, all others were subjected to aorta clamping for 70 min (ischemia) and withdrawal of clamp for 70 min (reperfusion). In the IPC and IPC + S groups, four cycles of postconditioning were performed between the phases of ischemia and reperfusion lasting 30 s each. In IPC + S and S groups, 3.4 mg/day of atorvastatin was given for seven days per gavage; 1 cm of the ileum were removed for histological study and the results were subjected to statistical treatment considering significant p < 0.05. Results: The average of intestinal lesion was 2 in the I/R group, 0.66 in the IPC group, 0 in the IPC + S group, 0 in the S group, and 0 in the SHAM group. Conclusion: The ischemic postconditioning and atorvastatin were capable of minimizing intestinal reperfusion injury, either alone or in combination.