Ovarian Metastasis from Colorectal Adenocarcinoma

Detalhes bibliográficos
Autor(a) principal: Fillmann,Lúcio Sarubbi
Data de Publicação: 2021
Outros Autores: Fillmann,Henrique Sarubbi, Fillmann,Laura Pinho, Tubiana,Ana Paula Reginatto, Ribeiro,Raquel, Coelho,Mariana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of Coloproctology (Rio de Janeiro. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632021000200176
Resumo: Abstract Introduction Ovarian metastases of gastrointestinal origin, also called Krukenberg tumors, have a guarded prognosis. Physicians need to look for alternatives in diagnosis and treatment for this clinical condition in order to improve the outcome of the patients. Objectives To report the experience of the authors in the treatment of these patients, and to perform a review of the literature on the epidemiology, clinical presentation, diagnosis, treatment, and prognosis for ovarian metastases from colorectal cancer. Methods We collected clinical information regarding the patients treated for ovarian metastasis from colorectal adenocarcinoma at our coloproctology service, and performed a search on the PubMed database using the terms colorectal cancer, ovarian metastasis, Krukenberg tumor and surgery. Conclusion Large abdominal tumors are the most frequent presentation of ovarian metastasis from colorectal cancer. The diagnosis is based on a histopathological analysis, levels of carcinoembryonic antigen (CEA) and cancer antigen 125 (CA-125), and immunohistochemical studies for the cytokeratin 20 (CK20), caudal-type homeobox 2 (CDX2) and vilina markers. Citoreductive surgical procedures are the most promising approach to treatment, with the highest impact on overall survival. The prognosis is negatively influenced by the extent of the metastasis, by citoreductive surgical procedures with persistence of macro- or microscopic foci of the disease, and by low scores on the general well-being index of the patient.
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spelling Ovarian Metastasis from Colorectal Adenocarcinomacolorectal cancerovarian metastasissurgeryAbstract Introduction Ovarian metastases of gastrointestinal origin, also called Krukenberg tumors, have a guarded prognosis. Physicians need to look for alternatives in diagnosis and treatment for this clinical condition in order to improve the outcome of the patients. Objectives To report the experience of the authors in the treatment of these patients, and to perform a review of the literature on the epidemiology, clinical presentation, diagnosis, treatment, and prognosis for ovarian metastases from colorectal cancer. Methods We collected clinical information regarding the patients treated for ovarian metastasis from colorectal adenocarcinoma at our coloproctology service, and performed a search on the PubMed database using the terms colorectal cancer, ovarian metastasis, Krukenberg tumor and surgery. Conclusion Large abdominal tumors are the most frequent presentation of ovarian metastasis from colorectal cancer. The diagnosis is based on a histopathological analysis, levels of carcinoembryonic antigen (CEA) and cancer antigen 125 (CA-125), and immunohistochemical studies for the cytokeratin 20 (CK20), caudal-type homeobox 2 (CDX2) and vilina markers. Citoreductive surgical procedures are the most promising approach to treatment, with the highest impact on overall survival. The prognosis is negatively influenced by the extent of the metastasis, by citoreductive surgical procedures with persistence of macro- or microscopic foci of the disease, and by low scores on the general well-being index of the patient.Sociedade Brasileira de Coloproctologia2021-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632021000200176Journal of Coloproctology (Rio de Janeiro) v.41 n.2 2021reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1055/s-0041-1730426info:eu-repo/semantics/openAccessFillmann,Lúcio SarubbiFillmann,Henrique SarubbiFillmann,Laura PinhoTubiana,Ana Paula ReginattoRibeiro,RaquelCoelho,Marianaeng2021-07-30T00:00:00Zoai:scielo:S2237-93632021000200176Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2021-07-30T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false
dc.title.none.fl_str_mv Ovarian Metastasis from Colorectal Adenocarcinoma
title Ovarian Metastasis from Colorectal Adenocarcinoma
spellingShingle Ovarian Metastasis from Colorectal Adenocarcinoma
Fillmann,Lúcio Sarubbi
colorectal cancer
ovarian metastasis
surgery
title_short Ovarian Metastasis from Colorectal Adenocarcinoma
title_full Ovarian Metastasis from Colorectal Adenocarcinoma
title_fullStr Ovarian Metastasis from Colorectal Adenocarcinoma
title_full_unstemmed Ovarian Metastasis from Colorectal Adenocarcinoma
title_sort Ovarian Metastasis from Colorectal Adenocarcinoma
author Fillmann,Lúcio Sarubbi
author_facet Fillmann,Lúcio Sarubbi
Fillmann,Henrique Sarubbi
Fillmann,Laura Pinho
Tubiana,Ana Paula Reginatto
Ribeiro,Raquel
Coelho,Mariana
author_role author
author2 Fillmann,Henrique Sarubbi
Fillmann,Laura Pinho
Tubiana,Ana Paula Reginatto
Ribeiro,Raquel
Coelho,Mariana
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Fillmann,Lúcio Sarubbi
Fillmann,Henrique Sarubbi
Fillmann,Laura Pinho
Tubiana,Ana Paula Reginatto
Ribeiro,Raquel
Coelho,Mariana
dc.subject.por.fl_str_mv colorectal cancer
ovarian metastasis
surgery
topic colorectal cancer
ovarian metastasis
surgery
description Abstract Introduction Ovarian metastases of gastrointestinal origin, also called Krukenberg tumors, have a guarded prognosis. Physicians need to look for alternatives in diagnosis and treatment for this clinical condition in order to improve the outcome of the patients. Objectives To report the experience of the authors in the treatment of these patients, and to perform a review of the literature on the epidemiology, clinical presentation, diagnosis, treatment, and prognosis for ovarian metastases from colorectal cancer. Methods We collected clinical information regarding the patients treated for ovarian metastasis from colorectal adenocarcinoma at our coloproctology service, and performed a search on the PubMed database using the terms colorectal cancer, ovarian metastasis, Krukenberg tumor and surgery. Conclusion Large abdominal tumors are the most frequent presentation of ovarian metastasis from colorectal cancer. The diagnosis is based on a histopathological analysis, levels of carcinoembryonic antigen (CEA) and cancer antigen 125 (CA-125), and immunohistochemical studies for the cytokeratin 20 (CK20), caudal-type homeobox 2 (CDX2) and vilina markers. Citoreductive surgical procedures are the most promising approach to treatment, with the highest impact on overall survival. The prognosis is negatively influenced by the extent of the metastasis, by citoreductive surgical procedures with persistence of macro- or microscopic foci of the disease, and by low scores on the general well-being index of the patient.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632021000200176
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1055/s-0041-1730426
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
dc.source.none.fl_str_mv Journal of Coloproctology (Rio de Janeiro) v.41 n.2 2021
reponame:Journal of Coloproctology (Rio de Janeiro. Online)
instname:Sociedade Brasileira de Coloproctologia (SBCP)
instacron:SBCP
instname_str Sociedade Brasileira de Coloproctologia (SBCP)
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reponame_str Journal of Coloproctology (Rio de Janeiro. Online)
collection Journal of Coloproctology (Rio de Janeiro. Online)
repository.name.fl_str_mv Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)
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