Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up

Detalhes bibliográficos
Autor(a) principal: Mahdipour,Mahsa
Data de Publicação: 2019
Outros Autores: Shafaghi,Afshin, Mansour-Ghanaei,Fariborz, Hojati,Amineh, Joukar,Farahnaz, Mavaddati,Sara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of Coloproctology (Rio de Janeiro. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632019000200115
Resumo: ABSTRACT Objective: Ulcerative colitis usually affects the rectum and potentially can involve the whole colon. Noninvasive methods such as fecal calprotectin measurement may be considered as a reliable and inexpensive approach in assessing disease severity or treatment change strategy. Methods: In this retrospective cross-sectional study, records of 56 ulcerative colitis patients who hospitalized with exacerbation between May 2016 and April 2017 were assessed based on IBD Data Bank Software in Gastrointestinal and Liver Diseases and Research Center (GLDRC), Guilan province, Iran between. A questionnaire of demographic characteristics, clinical findings and fecal calprotectin level was completed. Montreal classification severity of ulcerative colitis and Mayo disease activity index were scored. Data were analyzed for descriptive and analytical analysis. Results: Fecal calprotectin was significantly different in terms of disease severity based on both Mayo score (p = 0.007) and Montreal classification (p = 0.001). In patients with mild symptoms, no increase in fecal calprotectin was observed, but in patients with moderate and severe elevations in fecal calprotectin levels was significant. Also, C-Reactive Protein surge was related to disease severity (p = 0.02). Furthermore, regression comparison among high-chance patients based on fecal calprotectin was significantly related to higher Erythrocyte Sedimentation Rate levels and smoking, p = 0.01 and p = 0.05, respectively. Conclusion: It seems fecal calprotectin levels are related to the disease severity. Non-invasive methods, such as fecal calprotectin assay, may seem to be an alternative to aggressive, costly and time-consuming methods, such as colonoscopy and biopsy, to reduce the suffering of patients and ultimately help improve the patients’ life quality.
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spelling Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-upCalprotectinInflammatory bowel diseaseUlcerative colitisInflammationABSTRACT Objective: Ulcerative colitis usually affects the rectum and potentially can involve the whole colon. Noninvasive methods such as fecal calprotectin measurement may be considered as a reliable and inexpensive approach in assessing disease severity or treatment change strategy. Methods: In this retrospective cross-sectional study, records of 56 ulcerative colitis patients who hospitalized with exacerbation between May 2016 and April 2017 were assessed based on IBD Data Bank Software in Gastrointestinal and Liver Diseases and Research Center (GLDRC), Guilan province, Iran between. A questionnaire of demographic characteristics, clinical findings and fecal calprotectin level was completed. Montreal classification severity of ulcerative colitis and Mayo disease activity index were scored. Data were analyzed for descriptive and analytical analysis. Results: Fecal calprotectin was significantly different in terms of disease severity based on both Mayo score (p = 0.007) and Montreal classification (p = 0.001). In patients with mild symptoms, no increase in fecal calprotectin was observed, but in patients with moderate and severe elevations in fecal calprotectin levels was significant. Also, C-Reactive Protein surge was related to disease severity (p = 0.02). Furthermore, regression comparison among high-chance patients based on fecal calprotectin was significantly related to higher Erythrocyte Sedimentation Rate levels and smoking, p = 0.01 and p = 0.05, respectively. Conclusion: It seems fecal calprotectin levels are related to the disease severity. Non-invasive methods, such as fecal calprotectin assay, may seem to be an alternative to aggressive, costly and time-consuming methods, such as colonoscopy and biopsy, to reduce the suffering of patients and ultimately help improve the patients’ life quality.Sociedade Brasileira de Coloproctologia2019-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632019000200115Journal of Coloproctology (Rio de Janeiro) v.39 n.2 2019reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1016/j.jcol.2018.10.012info:eu-repo/semantics/openAccessMahdipour,MahsaShafaghi,AfshinMansour-Ghanaei,FariborzHojati,AminehJoukar,FarahnazMavaddati,Saraeng2019-06-10T00:00:00Zoai:scielo:S2237-93632019000200115Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2019-06-10T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false
dc.title.none.fl_str_mv Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up
title Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up
spellingShingle Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up
Mahdipour,Mahsa
Calprotectin
Inflammatory bowel disease
Ulcerative colitis
Inflammation
title_short Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up
title_full Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up
title_fullStr Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up
title_full_unstemmed Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up
title_sort Fecal calprotectin role in diagnosis of ulcerative colitis and treatment follow-up
author Mahdipour,Mahsa
author_facet Mahdipour,Mahsa
Shafaghi,Afshin
Mansour-Ghanaei,Fariborz
Hojati,Amineh
Joukar,Farahnaz
Mavaddati,Sara
author_role author
author2 Shafaghi,Afshin
Mansour-Ghanaei,Fariborz
Hojati,Amineh
Joukar,Farahnaz
Mavaddati,Sara
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Mahdipour,Mahsa
Shafaghi,Afshin
Mansour-Ghanaei,Fariborz
Hojati,Amineh
Joukar,Farahnaz
Mavaddati,Sara
dc.subject.por.fl_str_mv Calprotectin
Inflammatory bowel disease
Ulcerative colitis
Inflammation
topic Calprotectin
Inflammatory bowel disease
Ulcerative colitis
Inflammation
description ABSTRACT Objective: Ulcerative colitis usually affects the rectum and potentially can involve the whole colon. Noninvasive methods such as fecal calprotectin measurement may be considered as a reliable and inexpensive approach in assessing disease severity or treatment change strategy. Methods: In this retrospective cross-sectional study, records of 56 ulcerative colitis patients who hospitalized with exacerbation between May 2016 and April 2017 were assessed based on IBD Data Bank Software in Gastrointestinal and Liver Diseases and Research Center (GLDRC), Guilan province, Iran between. A questionnaire of demographic characteristics, clinical findings and fecal calprotectin level was completed. Montreal classification severity of ulcerative colitis and Mayo disease activity index were scored. Data were analyzed for descriptive and analytical analysis. Results: Fecal calprotectin was significantly different in terms of disease severity based on both Mayo score (p = 0.007) and Montreal classification (p = 0.001). In patients with mild symptoms, no increase in fecal calprotectin was observed, but in patients with moderate and severe elevations in fecal calprotectin levels was significant. Also, C-Reactive Protein surge was related to disease severity (p = 0.02). Furthermore, regression comparison among high-chance patients based on fecal calprotectin was significantly related to higher Erythrocyte Sedimentation Rate levels and smoking, p = 0.01 and p = 0.05, respectively. Conclusion: It seems fecal calprotectin levels are related to the disease severity. Non-invasive methods, such as fecal calprotectin assay, may seem to be an alternative to aggressive, costly and time-consuming methods, such as colonoscopy and biopsy, to reduce the suffering of patients and ultimately help improve the patients’ life quality.
publishDate 2019
dc.date.none.fl_str_mv 2019-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.jcol.2018.10.012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
dc.source.none.fl_str_mv Journal of Coloproctology (Rio de Janeiro) v.39 n.2 2019
reponame:Journal of Coloproctology (Rio de Janeiro. Online)
instname:Sociedade Brasileira de Coloproctologia (SBCP)
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instname_str Sociedade Brasileira de Coloproctologia (SBCP)
instacron_str SBCP
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reponame_str Journal of Coloproctology (Rio de Janeiro. Online)
collection Journal of Coloproctology (Rio de Janeiro. Online)
repository.name.fl_str_mv Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)
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