Fungal Colitis by Paracoccidioides brasiliensis: a case report

Detalhes bibliográficos
Autor(a) principal: Galeazzi,Carlos José
Data de Publicação: 2011
Outros Autores: Estofolete,Cássia Fernanda, Moraes Filho,Antônio Carlos Soares de, Simoni,Anderson Lubito, Gonçalves-Filho,Francisco de Assis, Netinho,João Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of Coloproctology (Rio de Janeiro. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632011000400013
Resumo: Paracoccidioidomycosis (PBM) is an infection caused by a dimorphic fungus called Paracoccidioides brasiliensis. It occurs in Latin America, with incidence of 1 to 3 per 100,000 inhabitants in endemic areas. The digestive tract is usually not affected, but when it occurs, it may lead to events similar to colorectal neoplasm and inflammatory bowel disease (IBD). This is a case report of a 68-year-old female patient, with diarrhea without blood or mucus for 6 months, weight loss of 8 kg over the period. Abdominal ultrasonography showed some mass in the right colon, suggestive of cancer and liver perihilar lymph node. Colonoscopy showed lesions suggestive of Crohn's disease. Biopsy showed chronic granulomatous colitis of fungal etiology: Paracoccidioidomycosis. The patient did not tolerate oral treatment with itraconazole and subsequently sulfadiazine, requiring hospital admission for the treatment with amphotericin B. The presence of Paracoccidioidomycosis in the digestive tract may be associated with bloody diarrhea, mucus, rectal hemorrhage, abdominal pain, malabsorption syndrome. Histopathological studies show the fungus and a chronic inflammatory infiltrate and granulation tissue. The differential diagnoses are tuberculosis, colorectal cancer and inflammatory bowel disease. The treatment is oral antifungal (itraconazole, sulfadiazine) or intravenous (amphotericin B) based. The case has caused diagnostic confusion between colon cancer (clinical and US) and Crohn's disease (colonoscopy).
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spelling Fungal Colitis by Paracoccidioides brasiliensis: a case reportParacoccidioidesmycosescolitisamphotericin BParacoccidioidomycosis (PBM) is an infection caused by a dimorphic fungus called Paracoccidioides brasiliensis. It occurs in Latin America, with incidence of 1 to 3 per 100,000 inhabitants in endemic areas. The digestive tract is usually not affected, but when it occurs, it may lead to events similar to colorectal neoplasm and inflammatory bowel disease (IBD). This is a case report of a 68-year-old female patient, with diarrhea without blood or mucus for 6 months, weight loss of 8 kg over the period. Abdominal ultrasonography showed some mass in the right colon, suggestive of cancer and liver perihilar lymph node. Colonoscopy showed lesions suggestive of Crohn's disease. Biopsy showed chronic granulomatous colitis of fungal etiology: Paracoccidioidomycosis. The patient did not tolerate oral treatment with itraconazole and subsequently sulfadiazine, requiring hospital admission for the treatment with amphotericin B. The presence of Paracoccidioidomycosis in the digestive tract may be associated with bloody diarrhea, mucus, rectal hemorrhage, abdominal pain, malabsorption syndrome. Histopathological studies show the fungus and a chronic inflammatory infiltrate and granulation tissue. The differential diagnoses are tuberculosis, colorectal cancer and inflammatory bowel disease. The treatment is oral antifungal (itraconazole, sulfadiazine) or intravenous (amphotericin B) based. The case has caused diagnostic confusion between colon cancer (clinical and US) and Crohn's disease (colonoscopy).Sociedade Brasileira de Coloproctologia2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632011000400013Journal of Coloproctology (Rio de Janeiro) v.31 n.4 2011reponame:Journal of Coloproctology (Rio de Janeiro. Online)instname:Sociedade Brasileira de Coloproctologia (SBCP)instacron:SBCP10.1590/S2237-93632011000400013info:eu-repo/semantics/openAccessGaleazzi,Carlos JoséEstofolete,Cássia FernandaMoraes Filho,Antônio Carlos Soares deSimoni,Anderson LubitoGonçalves-Filho,Francisco de AssisNetinho,João Gomeseng2012-05-07T00:00:00Zoai:scielo:S2237-93632011000400013Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-9363&lng=pt&nrm=isohttps://old.scielo.br/oai/scielo-oai.php||sbcp@sbcp.org.br2317-64232237-9363opendoar:2012-05-07T00:00Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)false
dc.title.none.fl_str_mv Fungal Colitis by Paracoccidioides brasiliensis: a case report
title Fungal Colitis by Paracoccidioides brasiliensis: a case report
spellingShingle Fungal Colitis by Paracoccidioides brasiliensis: a case report
Galeazzi,Carlos José
Paracoccidioides
mycoses
colitis
amphotericin B
title_short Fungal Colitis by Paracoccidioides brasiliensis: a case report
title_full Fungal Colitis by Paracoccidioides brasiliensis: a case report
title_fullStr Fungal Colitis by Paracoccidioides brasiliensis: a case report
title_full_unstemmed Fungal Colitis by Paracoccidioides brasiliensis: a case report
title_sort Fungal Colitis by Paracoccidioides brasiliensis: a case report
author Galeazzi,Carlos José
author_facet Galeazzi,Carlos José
Estofolete,Cássia Fernanda
Moraes Filho,Antônio Carlos Soares de
Simoni,Anderson Lubito
Gonçalves-Filho,Francisco de Assis
Netinho,João Gomes
author_role author
author2 Estofolete,Cássia Fernanda
Moraes Filho,Antônio Carlos Soares de
Simoni,Anderson Lubito
Gonçalves-Filho,Francisco de Assis
Netinho,João Gomes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Galeazzi,Carlos José
Estofolete,Cássia Fernanda
Moraes Filho,Antônio Carlos Soares de
Simoni,Anderson Lubito
Gonçalves-Filho,Francisco de Assis
Netinho,João Gomes
dc.subject.por.fl_str_mv Paracoccidioides
mycoses
colitis
amphotericin B
topic Paracoccidioides
mycoses
colitis
amphotericin B
description Paracoccidioidomycosis (PBM) is an infection caused by a dimorphic fungus called Paracoccidioides brasiliensis. It occurs in Latin America, with incidence of 1 to 3 per 100,000 inhabitants in endemic areas. The digestive tract is usually not affected, but when it occurs, it may lead to events similar to colorectal neoplasm and inflammatory bowel disease (IBD). This is a case report of a 68-year-old female patient, with diarrhea without blood or mucus for 6 months, weight loss of 8 kg over the period. Abdominal ultrasonography showed some mass in the right colon, suggestive of cancer and liver perihilar lymph node. Colonoscopy showed lesions suggestive of Crohn's disease. Biopsy showed chronic granulomatous colitis of fungal etiology: Paracoccidioidomycosis. The patient did not tolerate oral treatment with itraconazole and subsequently sulfadiazine, requiring hospital admission for the treatment with amphotericin B. The presence of Paracoccidioidomycosis in the digestive tract may be associated with bloody diarrhea, mucus, rectal hemorrhage, abdominal pain, malabsorption syndrome. Histopathological studies show the fungus and a chronic inflammatory infiltrate and granulation tissue. The differential diagnoses are tuberculosis, colorectal cancer and inflammatory bowel disease. The treatment is oral antifungal (itraconazole, sulfadiazine) or intravenous (amphotericin B) based. The case has caused diagnostic confusion between colon cancer (clinical and US) and Crohn's disease (colonoscopy).
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
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dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.relation.none.fl_str_mv 10.1590/S2237-93632011000400013
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
publisher.none.fl_str_mv Sociedade Brasileira de Coloproctologia
dc.source.none.fl_str_mv Journal of Coloproctology (Rio de Janeiro) v.31 n.4 2011
reponame:Journal of Coloproctology (Rio de Janeiro. Online)
instname:Sociedade Brasileira de Coloproctologia (SBCP)
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reponame_str Journal of Coloproctology (Rio de Janeiro. Online)
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repository.name.fl_str_mv Journal of Coloproctology (Rio de Janeiro. Online) - Sociedade Brasileira de Coloproctologia (SBCP)
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