Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Cirurgia Plástica (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-51752011000300005 |
Resumo: | BACKGROUND: Microcirculation dysfunction, as a consequence of localized vascular insufficiency, is considered to be one of the dominant causes of surgical flap necrosis. Several vasoactive drugs have been tested for the pharmacological treatment of tissue ischemia, with varying degrees of success. This study aimed to assess the impact of buflomedil and sildenafil on the viability of random skin flaps in rats. METHODS: Caudally pedicled skin flaps (10 x 3 cm) were created on the backs of rats. The animals were randomly assigned, in groups of 10, to three treatment groups: one group served as the vehicle control group, one group received buflomedil (10 mg/kg/d, orally), and a third group received the same dosage of sildenafil. Following seven days of dosing, the animals were sacrificed, and the viable flap area was determined. RESULTS: The average viable flap area for each group was: 16.2 ± 3.56 cm² (control group), 17.69 ± 2.54 cm² (buflomedil group), and 18.28 ± 3.74 cm² (sildenafil group). Data analysis by the Kruskal-Wallis test failed to show a statistically significant difference between the three groups. CONCLUSIONS: Neither buflomedil nor sildenafil showed a reduction in the necrotic area of random skin flaps in rats. |
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Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental studySurgical flapsPiperazinesPyrrolidinesNecrosis/prevention & controlRatsBACKGROUND: Microcirculation dysfunction, as a consequence of localized vascular insufficiency, is considered to be one of the dominant causes of surgical flap necrosis. Several vasoactive drugs have been tested for the pharmacological treatment of tissue ischemia, with varying degrees of success. This study aimed to assess the impact of buflomedil and sildenafil on the viability of random skin flaps in rats. METHODS: Caudally pedicled skin flaps (10 x 3 cm) were created on the backs of rats. The animals were randomly assigned, in groups of 10, to three treatment groups: one group served as the vehicle control group, one group received buflomedil (10 mg/kg/d, orally), and a third group received the same dosage of sildenafil. Following seven days of dosing, the animals were sacrificed, and the viable flap area was determined. RESULTS: The average viable flap area for each group was: 16.2 ± 3.56 cm² (control group), 17.69 ± 2.54 cm² (buflomedil group), and 18.28 ± 3.74 cm² (sildenafil group). Data analysis by the Kruskal-Wallis test failed to show a statistically significant difference between the three groups. CONCLUSIONS: Neither buflomedil nor sildenafil showed a reduction in the necrotic area of random skin flaps in rats.Sociedade Brasileira de Cirurgia Plástica2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-51752011000300005Revista Brasileira de Cirurgia Plástica v.26 n.3 2011reponame:Revista Brasileira de Cirurgia Plástica (Online)instname:Sociedade Brasileira de Cirurgia Plástica (SBCP)instacron:SBCP10.1590/S1983-51752011000300005info:eu-repo/semantics/openAccessFigueiredo,Jason C. AbrantesZampar,Antonio GustavoDestro,CristinaArias,Victor Eduardo AMorro,RebecaPinheiro,Adivânia de SouzaMélega,José Marcos de Andradeeng2011-12-09T00:00:00Zoai:scielo:S1983-51752011000300005Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=1983-5175&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.php||rbcp@cirurgiaplastica.org.br2177-12351983-5175opendoar:2011-12-09T00:00Revista Brasileira de Cirurgia Plástica (Online) - Sociedade Brasileira de Cirurgia Plástica (SBCP)false |
dc.title.none.fl_str_mv |
Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study |
title |
Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study |
spellingShingle |
Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study Figueiredo,Jason C. Abrantes Surgical flaps Piperazines Pyrrolidines Necrosis/prevention & control Rats |
title_short |
Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study |
title_full |
Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study |
title_fullStr |
Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study |
title_full_unstemmed |
Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study |
title_sort |
Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study |
author |
Figueiredo,Jason C. Abrantes |
author_facet |
Figueiredo,Jason C. Abrantes Zampar,Antonio Gustavo Destro,Cristina Arias,Victor Eduardo A Morro,Rebeca Pinheiro,Adivânia de Souza Mélega,José Marcos de Andrade |
author_role |
author |
author2 |
Zampar,Antonio Gustavo Destro,Cristina Arias,Victor Eduardo A Morro,Rebeca Pinheiro,Adivânia de Souza Mélega,José Marcos de Andrade |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Figueiredo,Jason C. Abrantes Zampar,Antonio Gustavo Destro,Cristina Arias,Victor Eduardo A Morro,Rebeca Pinheiro,Adivânia de Souza Mélega,José Marcos de Andrade |
dc.subject.por.fl_str_mv |
Surgical flaps Piperazines Pyrrolidines Necrosis/prevention & control Rats |
topic |
Surgical flaps Piperazines Pyrrolidines Necrosis/prevention & control Rats |
description |
BACKGROUND: Microcirculation dysfunction, as a consequence of localized vascular insufficiency, is considered to be one of the dominant causes of surgical flap necrosis. Several vasoactive drugs have been tested for the pharmacological treatment of tissue ischemia, with varying degrees of success. This study aimed to assess the impact of buflomedil and sildenafil on the viability of random skin flaps in rats. METHODS: Caudally pedicled skin flaps (10 x 3 cm) were created on the backs of rats. The animals were randomly assigned, in groups of 10, to three treatment groups: one group served as the vehicle control group, one group received buflomedil (10 mg/kg/d, orally), and a third group received the same dosage of sildenafil. Following seven days of dosing, the animals were sacrificed, and the viable flap area was determined. RESULTS: The average viable flap area for each group was: 16.2 ± 3.56 cm² (control group), 17.69 ± 2.54 cm² (buflomedil group), and 18.28 ± 3.74 cm² (sildenafil group). Data analysis by the Kruskal-Wallis test failed to show a statistically significant difference between the three groups. CONCLUSIONS: Neither buflomedil nor sildenafil showed a reduction in the necrotic area of random skin flaps in rats. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-51752011000300005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-51752011000300005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1983-51752011000300005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cirurgia Plástica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cirurgia Plástica |
dc.source.none.fl_str_mv |
Revista Brasileira de Cirurgia Plástica v.26 n.3 2011 reponame:Revista Brasileira de Cirurgia Plástica (Online) instname:Sociedade Brasileira de Cirurgia Plástica (SBCP) instacron:SBCP |
instname_str |
Sociedade Brasileira de Cirurgia Plástica (SBCP) |
instacron_str |
SBCP |
institution |
SBCP |
reponame_str |
Revista Brasileira de Cirurgia Plástica (Online) |
collection |
Revista Brasileira de Cirurgia Plástica (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Cirurgia Plástica (Online) - Sociedade Brasileira de Cirurgia Plástica (SBCP) |
repository.mail.fl_str_mv |
||rbcp@cirurgiaplastica.org.br |
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1754821114559725568 |