Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Food Science and Technology (Campinas) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100438 |
Resumo: | Abstract Evidences showed that Prognostic Nutritional Index (PNI) is one important predictive factor for some cancers. However, the association between PNI and colorectal cancer is still unclear. In this study, we aim to explore the association between PNI and death in patients with locally advanced colorectal cancer. We enrolled 400 patients with colorectal cancer. The pathological results was used to confirm it. The patients received radical resection. The PNI at baseline was set as the exposure variable, death was the outcome variable, and other potential confounders were also analyzed. There was no association between PNI and the deaths of local advanced colorectal cancer and radical resection of colorectal cancer (HR=0.88; 95% CI, 0.78-1.00).Applying the cubic spline function, we found that it is not linear between PNI and death. Two-piecewise cox model showed that there was 68% decrease of risk of deaths when PNI change per 1 (HR=0.32; 95% CI, 0.13-0.79) on the left side of the inflection point (41.35). On the right of the inflection point, there was no association between PNI and death. PNI and deaths are linear correlation. Within a certain range (PNI=26-41), PNI is an independent protective factor for death risk. |
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Food Science and Technology (Campinas) |
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Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort studyprognostic nutritional indexcolorectal cancerprognosisAbstract Evidences showed that Prognostic Nutritional Index (PNI) is one important predictive factor for some cancers. However, the association between PNI and colorectal cancer is still unclear. In this study, we aim to explore the association between PNI and death in patients with locally advanced colorectal cancer. We enrolled 400 patients with colorectal cancer. The pathological results was used to confirm it. The patients received radical resection. The PNI at baseline was set as the exposure variable, death was the outcome variable, and other potential confounders were also analyzed. There was no association between PNI and the deaths of local advanced colorectal cancer and radical resection of colorectal cancer (HR=0.88; 95% CI, 0.78-1.00).Applying the cubic spline function, we found that it is not linear between PNI and death. Two-piecewise cox model showed that there was 68% decrease of risk of deaths when PNI change per 1 (HR=0.32; 95% CI, 0.13-0.79) on the left side of the inflection point (41.35). On the right of the inflection point, there was no association between PNI and death. PNI and deaths are linear correlation. Within a certain range (PNI=26-41), PNI is an independent protective factor for death risk.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100438Food Science and Technology v.42 2022reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.36320info:eu-repo/semantics/openAccessZHOU,HongqiWANG,WenlingZHANG,RuyiDONG,HongminWANG,GangCHEN,WeiweiLI,Guodongeng2022-02-22T00:00:00Zoai:scielo:S0101-20612022000100438Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2022-02-22T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false |
dc.title.none.fl_str_mv |
Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study |
title |
Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study |
spellingShingle |
Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study ZHOU,Hongqi prognostic nutritional index colorectal cancer prognosis |
title_short |
Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study |
title_full |
Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study |
title_fullStr |
Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study |
title_full_unstemmed |
Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study |
title_sort |
Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study |
author |
ZHOU,Hongqi |
author_facet |
ZHOU,Hongqi WANG,Wenling ZHANG,Ruyi DONG,Hongmin WANG,Gang CHEN,Weiwei LI,Guodong |
author_role |
author |
author2 |
WANG,Wenling ZHANG,Ruyi DONG,Hongmin WANG,Gang CHEN,Weiwei LI,Guodong |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
ZHOU,Hongqi WANG,Wenling ZHANG,Ruyi DONG,Hongmin WANG,Gang CHEN,Weiwei LI,Guodong |
dc.subject.por.fl_str_mv |
prognostic nutritional index colorectal cancer prognosis |
topic |
prognostic nutritional index colorectal cancer prognosis |
description |
Abstract Evidences showed that Prognostic Nutritional Index (PNI) is one important predictive factor for some cancers. However, the association between PNI and colorectal cancer is still unclear. In this study, we aim to explore the association between PNI and death in patients with locally advanced colorectal cancer. We enrolled 400 patients with colorectal cancer. The pathological results was used to confirm it. The patients received radical resection. The PNI at baseline was set as the exposure variable, death was the outcome variable, and other potential confounders were also analyzed. There was no association between PNI and the deaths of local advanced colorectal cancer and radical resection of colorectal cancer (HR=0.88; 95% CI, 0.78-1.00).Applying the cubic spline function, we found that it is not linear between PNI and death. Two-piecewise cox model showed that there was 68% decrease of risk of deaths when PNI change per 1 (HR=0.32; 95% CI, 0.13-0.79) on the left side of the inflection point (41.35). On the right of the inflection point, there was no association between PNI and death. PNI and deaths are linear correlation. Within a certain range (PNI=26-41), PNI is an independent protective factor for death risk. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100438 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000100438 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/fst.36320 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos |
dc.source.none.fl_str_mv |
Food Science and Technology v.42 2022 reponame:Food Science and Technology (Campinas) instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) instacron:SBCTA |
instname_str |
Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
instacron_str |
SBCTA |
institution |
SBCTA |
reponame_str |
Food Science and Technology (Campinas) |
collection |
Food Science and Technology (Campinas) |
repository.name.fl_str_mv |
Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA) |
repository.mail.fl_str_mv |
||revista@sbcta.org.br |
_version_ |
1752126331509800960 |