Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/57730 http://dx.doi.org/10.3389/fnut.2022.802562 |
Resumo: | Purpose: To evaluate whether the prognostic nutritional index (PNI) is related to the oxygen therapy requirement at hospital admission and to ascertain the prognostic effect of the PNI and the oxygen therapy requirement as predictors of hospital length of stay in patients with moderate to severe coronavirus disease 2019 (COVID-19). Methods: This is a post-hoc analysis in hospitalized patients with moderate to severe COVID-19. The participants were categorized: (1) non-oxygen therapy (moderate COVID-19 not requiring oxygen therapy); (2) nasal cannula therapy (severe COVID-19 requiring nasal cannula oxygen therapy); and (3) high-flow therapy (severe COVID-19 requiring high-flow oxygen therapy). PNI was calculated for each patient according to the following equation: serum albumin [g/dL] × 10 + total lymphocyte count [per mm3 ] × 0.005. The participants were categorized into malnutrition (PNI < 40), mild malnutrition (PNI 40–45), and non-malnutrition (PNI > 45). Results: According to PNI, malnutrition was more prevalent in the high-flow therapy group (94.9%; P < 0.001) with significantly lower PNI compared to both groups even after adjusting for the center and C-reactive protein. Patients in the high-flow therapy group [9 days (95% CI 7.2, 10.7), P < 0.001] and malnutrition status [7 days (95% CI 6.6, 7.4), P = 0.016] showed a significant longer hospital length of stay compared to their counterparts. The multivariable Cox proportional hazard models showed significant associations between both oxygen therapy requirement and PNI categories and hospital discharge. Conclusion: In addition to oxygen therapy requirement, low PNI was associated with longer hospital length of stay. Our findings suggest that PNI could be useful in the assessment of nutritional status related to the prognosis of patients with moderate to severe COVID-19 |
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Reis, Bruna ZavarizeFernandes, Alan LinsMurai, Igor HisashiPereira, Rosa Maria Rodrigues2024-03-01T21:37:30Z2024-03-01T21:37:30Z2022-04FERNANDES, Alan Lins; REIS, Bruna Zavarize; MUIRAI, Igor Hisashi; PEREIRA, Rosa Maria Rodrigues. Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses. Frontiers in Nutrition, [S.l.], v. 9, p. 1-9, 5 abr. 2022. DOI: 10.3389/fnut.2022.802562. Disponível em: https://www.frontiersin.org/articles/10.3389/fnut.2022.802562/full. Acesso em: 16 fev. 2024.https://repositorio.ufrn.br/handle/123456789/57730http://dx.doi.org/10.3389/fnut.2022.802562Frontiers in NutritionAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessSARS-CoV-2 infectionCOVID-19MalnutritionPrognosisNutritional statusAssessmentPrognostic nutritional indexPNIPrognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analysesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePurpose: To evaluate whether the prognostic nutritional index (PNI) is related to the oxygen therapy requirement at hospital admission and to ascertain the prognostic effect of the PNI and the oxygen therapy requirement as predictors of hospital length of stay in patients with moderate to severe coronavirus disease 2019 (COVID-19). Methods: This is a post-hoc analysis in hospitalized patients with moderate to severe COVID-19. The participants were categorized: (1) non-oxygen therapy (moderate COVID-19 not requiring oxygen therapy); (2) nasal cannula therapy (severe COVID-19 requiring nasal cannula oxygen therapy); and (3) high-flow therapy (severe COVID-19 requiring high-flow oxygen therapy). PNI was calculated for each patient according to the following equation: serum albumin [g/dL] × 10 + total lymphocyte count [per mm3 ] × 0.005. The participants were categorized into malnutrition (PNI < 40), mild malnutrition (PNI 40–45), and non-malnutrition (PNI > 45). Results: According to PNI, malnutrition was more prevalent in the high-flow therapy group (94.9%; P < 0.001) with significantly lower PNI compared to both groups even after adjusting for the center and C-reactive protein. Patients in the high-flow therapy group [9 days (95% CI 7.2, 10.7), P < 0.001] and malnutrition status [7 days (95% CI 6.6, 7.4), P = 0.016] showed a significant longer hospital length of stay compared to their counterparts. The multivariable Cox proportional hazard models showed significant associations between both oxygen therapy requirement and PNI categories and hospital discharge. Conclusion: In addition to oxygen therapy requirement, low PNI was associated with longer hospital length of stay. Our findings suggest that PNI could be useful in the assessment of nutritional status related to the prognosis of patients with moderate to severe COVID-19engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALPrognosticNutritional_Fernandes_2022.pdfPrognosticNutritional_Fernandes_2022.pdfapplication/pdf397545https://repositorio.ufrn.br/bitstream/123456789/57730/1/PrognosticNutritional_Fernandes_2022.pdf068426755d487bab1e02106a828eb0f9MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/57730/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/57730/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/577302024-03-01 18:37:30.879oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-03-01T21:37:30Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses |
title |
Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses |
spellingShingle |
Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses Reis, Bruna Zavarize SARS-CoV-2 infection COVID-19 Malnutrition Prognosis Nutritional status Assessment Prognostic nutritional index PNI |
title_short |
Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses |
title_full |
Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses |
title_fullStr |
Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses |
title_full_unstemmed |
Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses |
title_sort |
Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses |
author |
Reis, Bruna Zavarize |
author_facet |
Reis, Bruna Zavarize Fernandes, Alan Lins Murai, Igor Hisashi Pereira, Rosa Maria Rodrigues |
author_role |
author |
author2 |
Fernandes, Alan Lins Murai, Igor Hisashi Pereira, Rosa Maria Rodrigues |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Reis, Bruna Zavarize Fernandes, Alan Lins Murai, Igor Hisashi Pereira, Rosa Maria Rodrigues |
dc.subject.por.fl_str_mv |
SARS-CoV-2 infection COVID-19 Malnutrition Prognosis Nutritional status Assessment Prognostic nutritional index PNI |
topic |
SARS-CoV-2 infection COVID-19 Malnutrition Prognosis Nutritional status Assessment Prognostic nutritional index PNI |
description |
Purpose: To evaluate whether the prognostic nutritional index (PNI) is related to the oxygen therapy requirement at hospital admission and to ascertain the prognostic effect of the PNI and the oxygen therapy requirement as predictors of hospital length of stay in patients with moderate to severe coronavirus disease 2019 (COVID-19). Methods: This is a post-hoc analysis in hospitalized patients with moderate to severe COVID-19. The participants were categorized: (1) non-oxygen therapy (moderate COVID-19 not requiring oxygen therapy); (2) nasal cannula therapy (severe COVID-19 requiring nasal cannula oxygen therapy); and (3) high-flow therapy (severe COVID-19 requiring high-flow oxygen therapy). PNI was calculated for each patient according to the following equation: serum albumin [g/dL] × 10 + total lymphocyte count [per mm3 ] × 0.005. The participants were categorized into malnutrition (PNI < 40), mild malnutrition (PNI 40–45), and non-malnutrition (PNI > 45). Results: According to PNI, malnutrition was more prevalent in the high-flow therapy group (94.9%; P < 0.001) with significantly lower PNI compared to both groups even after adjusting for the center and C-reactive protein. Patients in the high-flow therapy group [9 days (95% CI 7.2, 10.7), P < 0.001] and malnutrition status [7 days (95% CI 6.6, 7.4), P = 0.016] showed a significant longer hospital length of stay compared to their counterparts. The multivariable Cox proportional hazard models showed significant associations between both oxygen therapy requirement and PNI categories and hospital discharge. Conclusion: In addition to oxygen therapy requirement, low PNI was associated with longer hospital length of stay. Our findings suggest that PNI could be useful in the assessment of nutritional status related to the prognosis of patients with moderate to severe COVID-19 |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022-04 |
dc.date.accessioned.fl_str_mv |
2024-03-01T21:37:30Z |
dc.date.available.fl_str_mv |
2024-03-01T21:37:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERNANDES, Alan Lins; REIS, Bruna Zavarize; MUIRAI, Igor Hisashi; PEREIRA, Rosa Maria Rodrigues. Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses. Frontiers in Nutrition, [S.l.], v. 9, p. 1-9, 5 abr. 2022. DOI: 10.3389/fnut.2022.802562. Disponível em: https://www.frontiersin.org/articles/10.3389/fnut.2022.802562/full. Acesso em: 16 fev. 2024. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/57730 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.3389/fnut.2022.802562 |
identifier_str_mv |
FERNANDES, Alan Lins; REIS, Bruna Zavarize; MUIRAI, Igor Hisashi; PEREIRA, Rosa Maria Rodrigues. Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses. Frontiers in Nutrition, [S.l.], v. 9, p. 1-9, 5 abr. 2022. DOI: 10.3389/fnut.2022.802562. Disponível em: https://www.frontiersin.org/articles/10.3389/fnut.2022.802562/full. Acesso em: 16 fev. 2024. |
url |
https://repositorio.ufrn.br/handle/123456789/57730 http://dx.doi.org/10.3389/fnut.2022.802562 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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Frontiers in Nutrition |
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Frontiers in Nutrition |
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