The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo

Detalhes bibliográficos
Autor(a) principal: ZENG,Shi
Data de Publicação: 2022
Outros Autores: ZHAO,Xin, HUO,Jianhong, YANG,Huajiang, YANG,Donghong, LIU,Li
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Food Science and Technology (Campinas)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000101411
Resumo: Abstract This study looked at the inhibitory effects of Apocynum venetum tea flavonoids extract (AVTFE) on mouse glioma G422 cells. Through the use of high performance liquid chromatography, the flavonoids in AVTFE were examined (HPLC). Meanwhile, mice were injected with glioma G422 cells to create a mouse model of a transplanted tumor. AVTFE might significantly (P < 0.05) lower serum sIL-2R content and raise serum IFN-γ content in tumor-bearing mice, according to an analysis of mouse serum. In addition to reducing the rise in spleen weight and spleen index in mice brought on by transplanted tumors, AVTFE can limit the development of transplanted tumors in G422 cell mice. AVTFE can also boost immunity by encouraging T and B lymphocyte proliferation in tumor-bearing animals. AVTFE was therefore verified to have immunomodulatory properties and to limit the proliferation of glioma G422 cells.
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spelling The impact of Apocynum venetum tea flavonoids on G422 glioma in vivoApocynum venetumteaG422 cellsgliomaimmunityspleenAbstract This study looked at the inhibitory effects of Apocynum venetum tea flavonoids extract (AVTFE) on mouse glioma G422 cells. Through the use of high performance liquid chromatography, the flavonoids in AVTFE were examined (HPLC). Meanwhile, mice were injected with glioma G422 cells to create a mouse model of a transplanted tumor. AVTFE might significantly (P < 0.05) lower serum sIL-2R content and raise serum IFN-γ content in tumor-bearing mice, according to an analysis of mouse serum. In addition to reducing the rise in spleen weight and spleen index in mice brought on by transplanted tumors, AVTFE can limit the development of transplanted tumors in G422 cell mice. AVTFE can also boost immunity by encouraging T and B lymphocyte proliferation in tumor-bearing animals. AVTFE was therefore verified to have immunomodulatory properties and to limit the proliferation of glioma G422 cells.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000101411Food Science and Technology v.42 2022reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.84322info:eu-repo/semantics/openAccessZENG,ShiZHAO,XinHUO,JianhongYANG,HuajiangYANG,DonghongLIU,Lieng2022-11-10T00:00:00Zoai:scielo:S0101-20612022000101411Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2022-11-10T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false
dc.title.none.fl_str_mv The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo
title The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo
spellingShingle The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo
ZENG,Shi
Apocynum venetum
tea
G422 cells
glioma
immunity
spleen
title_short The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo
title_full The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo
title_fullStr The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo
title_full_unstemmed The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo
title_sort The impact of Apocynum venetum tea flavonoids on G422 glioma in vivo
author ZENG,Shi
author_facet ZENG,Shi
ZHAO,Xin
HUO,Jianhong
YANG,Huajiang
YANG,Donghong
LIU,Li
author_role author
author2 ZHAO,Xin
HUO,Jianhong
YANG,Huajiang
YANG,Donghong
LIU,Li
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv ZENG,Shi
ZHAO,Xin
HUO,Jianhong
YANG,Huajiang
YANG,Donghong
LIU,Li
dc.subject.por.fl_str_mv Apocynum venetum
tea
G422 cells
glioma
immunity
spleen
topic Apocynum venetum
tea
G422 cells
glioma
immunity
spleen
description Abstract This study looked at the inhibitory effects of Apocynum venetum tea flavonoids extract (AVTFE) on mouse glioma G422 cells. Through the use of high performance liquid chromatography, the flavonoids in AVTFE were examined (HPLC). Meanwhile, mice were injected with glioma G422 cells to create a mouse model of a transplanted tumor. AVTFE might significantly (P < 0.05) lower serum sIL-2R content and raise serum IFN-γ content in tumor-bearing mice, according to an analysis of mouse serum. In addition to reducing the rise in spleen weight and spleen index in mice brought on by transplanted tumors, AVTFE can limit the development of transplanted tumors in G422 cell mice. AVTFE can also boost immunity by encouraging T and B lymphocyte proliferation in tumor-bearing animals. AVTFE was therefore verified to have immunomodulatory properties and to limit the proliferation of glioma G422 cells.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000101411
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612022000101411
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/fst.84322
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
dc.source.none.fl_str_mv Food Science and Technology v.42 2022
reponame:Food Science and Technology (Campinas)
instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron:SBCTA
instname_str Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron_str SBCTA
institution SBCTA
reponame_str Food Science and Technology (Campinas)
collection Food Science and Technology (Campinas)
repository.name.fl_str_mv Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
repository.mail.fl_str_mv ||revista@sbcta.org.br
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