In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents

Detalhes bibliográficos
Autor(a) principal: WANG,Xiaoyue
Data de Publicação: 2020
Outros Autores: GONG,Xiaoyan, ZHANG,Huina, ZHU,Wanshan, JIANG,Zewu, SHI,Yujing, LI,Li
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Food Science and Technology (Campinas)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000200476
Resumo: Abstract To determine in vitro anti-aging activity and identify the active chemical constituents in Ginkgo leaf extracts. The antioxidant properties of Ginkgo biloba leaves extracts were evaluated using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging and 2,2’-azino-bis (3-ethylbenzothiazoline)-6 sulfonic acid radical (ABTS) scavenging assays. The inhibitory effects of extracts and chemical constituents on reactive oxygen species, matrix metalloproteinase-1 (MMP-1) and collagen tpye I level were tested using human dermal fibroblasts (HDFs). Reverse-phase liquid chromatography (RPLC) and ultra-performance liquid chromatography tandem mass spectroscopy (UPLC/MS/MS) were used to quantitatively analyze flavonoids and terpene trilactones in the extraction. The established quantitative analysis method was validated according to the regulatory guidelines. The extraction and compounds kaempferol 3-O-β-D-glucopyranoside, isorhamnetin-3-O-glucoside, myricetin, ginkgolide A and bilobalide could have potential anti-aging activities of G. biloba. The results suggest that G. biloba could be used as anti-aging products and as a cosmetic and medicinal raw material.
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spelling In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituentsGinkgo leafantioxidantmatrix metalloproteinase-1collagen Ichemical analysisAbstract To determine in vitro anti-aging activity and identify the active chemical constituents in Ginkgo leaf extracts. The antioxidant properties of Ginkgo biloba leaves extracts were evaluated using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging and 2,2’-azino-bis (3-ethylbenzothiazoline)-6 sulfonic acid radical (ABTS) scavenging assays. The inhibitory effects of extracts and chemical constituents on reactive oxygen species, matrix metalloproteinase-1 (MMP-1) and collagen tpye I level were tested using human dermal fibroblasts (HDFs). Reverse-phase liquid chromatography (RPLC) and ultra-performance liquid chromatography tandem mass spectroscopy (UPLC/MS/MS) were used to quantitatively analyze flavonoids and terpene trilactones in the extraction. The established quantitative analysis method was validated according to the regulatory guidelines. The extraction and compounds kaempferol 3-O-β-D-glucopyranoside, isorhamnetin-3-O-glucoside, myricetin, ginkgolide A and bilobalide could have potential anti-aging activities of G. biloba. The results suggest that G. biloba could be used as anti-aging products and as a cosmetic and medicinal raw material.Sociedade Brasileira de Ciência e Tecnologia de Alimentos2020-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000200476Food Science and Technology v.40 n.2 2020reponame:Food Science and Technology (Campinas)instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)instacron:SBCTA10.1590/fst.02219info:eu-repo/semantics/openAccessWANG,XiaoyueGONG,XiaoyanZHANG,HuinaZHU,WanshanJIANG,ZewuSHI,YujingLI,Lieng2020-05-27T00:00:00Zoai:scielo:S0101-20612020000200476Revistahttp://www.scielo.br/ctaONGhttps://old.scielo.br/oai/scielo-oai.php||revista@sbcta.org.br1678-457X0101-2061opendoar:2020-05-27T00:00Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)false
dc.title.none.fl_str_mv In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents
title In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents
spellingShingle In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents
WANG,Xiaoyue
Ginkgo leaf
antioxidant
matrix metalloproteinase-1
collagen I
chemical analysis
title_short In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents
title_full In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents
title_fullStr In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents
title_full_unstemmed In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents
title_sort In vitro anti-aging activities of ginkgo biloba leaf extract and its chemical constituents
author WANG,Xiaoyue
author_facet WANG,Xiaoyue
GONG,Xiaoyan
ZHANG,Huina
ZHU,Wanshan
JIANG,Zewu
SHI,Yujing
LI,Li
author_role author
author2 GONG,Xiaoyan
ZHANG,Huina
ZHU,Wanshan
JIANG,Zewu
SHI,Yujing
LI,Li
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv WANG,Xiaoyue
GONG,Xiaoyan
ZHANG,Huina
ZHU,Wanshan
JIANG,Zewu
SHI,Yujing
LI,Li
dc.subject.por.fl_str_mv Ginkgo leaf
antioxidant
matrix metalloproteinase-1
collagen I
chemical analysis
topic Ginkgo leaf
antioxidant
matrix metalloproteinase-1
collagen I
chemical analysis
description Abstract To determine in vitro anti-aging activity and identify the active chemical constituents in Ginkgo leaf extracts. The antioxidant properties of Ginkgo biloba leaves extracts were evaluated using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) scavenging and 2,2’-azino-bis (3-ethylbenzothiazoline)-6 sulfonic acid radical (ABTS) scavenging assays. The inhibitory effects of extracts and chemical constituents on reactive oxygen species, matrix metalloproteinase-1 (MMP-1) and collagen tpye I level were tested using human dermal fibroblasts (HDFs). Reverse-phase liquid chromatography (RPLC) and ultra-performance liquid chromatography tandem mass spectroscopy (UPLC/MS/MS) were used to quantitatively analyze flavonoids and terpene trilactones in the extraction. The established quantitative analysis method was validated according to the regulatory guidelines. The extraction and compounds kaempferol 3-O-β-D-glucopyranoside, isorhamnetin-3-O-glucoside, myricetin, ginkgolide A and bilobalide could have potential anti-aging activities of G. biloba. The results suggest that G. biloba could be used as anti-aging products and as a cosmetic and medicinal raw material.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000200476
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000200476
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/fst.02219
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
publisher.none.fl_str_mv Sociedade Brasileira de Ciência e Tecnologia de Alimentos
dc.source.none.fl_str_mv Food Science and Technology v.40 n.2 2020
reponame:Food Science and Technology (Campinas)
instname:Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron:SBCTA
instname_str Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
instacron_str SBCTA
institution SBCTA
reponame_str Food Science and Technology (Campinas)
collection Food Science and Technology (Campinas)
repository.name.fl_str_mv Food Science and Technology (Campinas) - Sociedade Brasileira de Ciência e Tecnologia de Alimentos (SBCTA)
repository.mail.fl_str_mv ||revista@sbcta.org.br
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