DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms

Detalhes bibliográficos
Autor(a) principal: Gaspar,Neide Kalil
Data de Publicação: 2016
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000600776
Resumo: Abstract The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a negative regulator of fibrotic events induced by TGFβ1. Dehydroepiandrosterone (DHEA) is an immunomodulatory hormone essential for PPAR functions, and is reduced in some processes characterized by fibrosis. Although scarring alopecia characteristically develops in the female biological period in which occurs decreased production of DHEA, there are no data in the literature relating its reduction to fibrogenic process of this condition. This article aims to review the fibrogenic activity of TGFβ1, its control by PPAR and its relation with DHEA in the frontal fibrosing alopecia.
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spelling DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanismsDHEAFFAFrontal fibrosing alopeciaAlopeciaDehydroepiandrosteronePPAR gammaTransforming growth factor alphaAbstract The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a negative regulator of fibrotic events induced by TGFβ1. Dehydroepiandrosterone (DHEA) is an immunomodulatory hormone essential for PPAR functions, and is reduced in some processes characterized by fibrosis. Although scarring alopecia characteristically develops in the female biological period in which occurs decreased production of DHEA, there are no data in the literature relating its reduction to fibrogenic process of this condition. This article aims to review the fibrogenic activity of TGFβ1, its control by PPAR and its relation with DHEA in the frontal fibrosing alopecia.Sociedade Brasileira de Dermatologia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000600776Anais Brasileiros de Dermatologia v.91 n.6 2016reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20165029info:eu-repo/semantics/openAccessGaspar,Neide Kalileng2017-01-06T00:00:00Zoai:scielo:S0365-05962016000600776Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2017-01-06T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms
title DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms
spellingShingle DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms
Gaspar,Neide Kalil
DHEA
FFA
Frontal fibrosing alopecia
Alopecia
Dehydroepiandrosterone
PPAR gamma
Transforming growth factor alpha
title_short DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms
title_full DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms
title_fullStr DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms
title_full_unstemmed DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms
title_sort DHEA and frontal fibrosing alopecia: molecular and physiopathological mechanisms
author Gaspar,Neide Kalil
author_facet Gaspar,Neide Kalil
author_role author
dc.contributor.author.fl_str_mv Gaspar,Neide Kalil
dc.subject.por.fl_str_mv DHEA
FFA
Frontal fibrosing alopecia
Alopecia
Dehydroepiandrosterone
PPAR gamma
Transforming growth factor alpha
topic DHEA
FFA
Frontal fibrosing alopecia
Alopecia
Dehydroepiandrosterone
PPAR gamma
Transforming growth factor alpha
description Abstract The transforming growth factor-beta 1 (TGFβ1) promotes fibrosis, differentiating epithelial cells and quiescent fibroblasts into myofibroblasts and increasing expression of extracellular matrix. Recent investigations have shown that PPAR (peroxisome proliferator-activated receptor*) is a negative regulator of fibrotic events induced by TGFβ1. Dehydroepiandrosterone (DHEA) is an immunomodulatory hormone essential for PPAR functions, and is reduced in some processes characterized by fibrosis. Although scarring alopecia characteristically develops in the female biological period in which occurs decreased production of DHEA, there are no data in the literature relating its reduction to fibrogenic process of this condition. This article aims to review the fibrogenic activity of TGFβ1, its control by PPAR and its relation with DHEA in the frontal fibrosing alopecia.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000600776
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000600776
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20165029
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.91 n.6 2016
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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