Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosa

Detalhes bibliográficos
Autor(a) principal: Almeida Jr.,Hiram Larangeira de
Data de Publicação: 2013
Outros Autores: Monteiro,Luciane, Silva,Ricardo Marques e, Rocha,Nara Moreira, Scheffer,Hans
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000600966
Resumo: In dystrophic epidermolysis bullosa the genetic defect of anchoring fibrils leads to cleavage beneath the basement membrane, with its consequent loss. We performed scanning electron microscopy of an inverted blister roof of a case of dystrophic epidermolysis bullosa, confirmed by immunomapping and gene sequencing. With a magnification of 2000 times a net attached to the blister roof could be easily identified. This net was composed of intertwined flat fibers. With higher magnifications, different fiber sizes could be observed, some thin fibers measuring around 80 nm and thicker ones measuring between 200 and 300 nm.
id SBD-1_3b46394f171b008284396a99cdf34c1b
oai_identifier_str oai:scielo:S0365-05962013000600966
network_acronym_str SBD-1
network_name_str Anais brasileiros de dermatologia (Online)
repository_id_str
spelling Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosaBasement membraneEpidermolysis bullosa dystrophicaMicroscopy, electron, scanningSkin diseases, vesiculobullousIn dystrophic epidermolysis bullosa the genetic defect of anchoring fibrils leads to cleavage beneath the basement membrane, with its consequent loss. We performed scanning electron microscopy of an inverted blister roof of a case of dystrophic epidermolysis bullosa, confirmed by immunomapping and gene sequencing. With a magnification of 2000 times a net attached to the blister roof could be easily identified. This net was composed of intertwined flat fibers. With higher magnifications, different fiber sizes could be observed, some thin fibers measuring around 80 nm and thicker ones measuring between 200 and 300 nm.Sociedade Brasileira de Dermatologia2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000600966Anais Brasileiros de Dermatologia v.88 n.6 2013reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20131743info:eu-repo/semantics/openAccessAlmeida Jr.,Hiram Larangeira deMonteiro,LucianeSilva,Ricardo Marques eRocha,Nara MoreiraScheffer,Hanseng2014-08-29T00:00:00Zoai:scielo:S0365-05962013000600966Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2014-08-29T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosa
title Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosa
spellingShingle Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosa
Almeida Jr.,Hiram Larangeira de
Basement membrane
Epidermolysis bullosa dystrophica
Microscopy, electron, scanning
Skin diseases, vesiculobullous
title_short Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosa
title_full Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosa
title_fullStr Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosa
title_full_unstemmed Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosa
title_sort Scanning electron microscopy of a blister roof in dystrophic epidermolysis bullosa
author Almeida Jr.,Hiram Larangeira de
author_facet Almeida Jr.,Hiram Larangeira de
Monteiro,Luciane
Silva,Ricardo Marques e
Rocha,Nara Moreira
Scheffer,Hans
author_role author
author2 Monteiro,Luciane
Silva,Ricardo Marques e
Rocha,Nara Moreira
Scheffer,Hans
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Almeida Jr.,Hiram Larangeira de
Monteiro,Luciane
Silva,Ricardo Marques e
Rocha,Nara Moreira
Scheffer,Hans
dc.subject.por.fl_str_mv Basement membrane
Epidermolysis bullosa dystrophica
Microscopy, electron, scanning
Skin diseases, vesiculobullous
topic Basement membrane
Epidermolysis bullosa dystrophica
Microscopy, electron, scanning
Skin diseases, vesiculobullous
description In dystrophic epidermolysis bullosa the genetic defect of anchoring fibrils leads to cleavage beneath the basement membrane, with its consequent loss. We performed scanning electron microscopy of an inverted blister roof of a case of dystrophic epidermolysis bullosa, confirmed by immunomapping and gene sequencing. With a magnification of 2000 times a net attached to the blister roof could be easily identified. This net was composed of intertwined flat fibers. With higher magnifications, different fiber sizes could be observed, some thin fibers measuring around 80 nm and thicker ones measuring between 200 and 300 nm.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000600966
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962013000600966
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20131743
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.88 n.6 2013
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
_version_ 1752126419084771328

Registros relacionados