Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Mendaçolli,Paola Jung
Data de Publicação: 2015
Outros Autores: Brianezi,Gabrielli, Schmitt,Juliano Vilaverde, Marques,Mariângela Esther Alencar, Miot,Hélio Amante
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874
Resumo: Abstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype.
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spelling Nuclear morphometry and chromatin textural characteristics of basal cell carcinomaCarcinoma, basal cellChromatinKaryometryImage processing, computer-assistedPrognosisAbstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype.Sociedade Brasileira de Dermatologia2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874Anais Brasileiros de Dermatologia v.90 n.6 2015reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20154076info:eu-repo/semantics/openAccessMendaçolli,Paola JungBrianezi,GabrielliSchmitt,Juliano VilaverdeMarques,Mariângela Esther AlencarMiot,Hélio Amanteeng2015-12-22T00:00:00Zoai:scielo:S0365-05962015000600874Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2015-12-22T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
title Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
spellingShingle Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
Mendaçolli,Paola Jung
Carcinoma, basal cell
Chromatin
Karyometry
Image processing, computer-assisted
Prognosis
title_short Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
title_full Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
title_fullStr Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
title_full_unstemmed Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
title_sort Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
author Mendaçolli,Paola Jung
author_facet Mendaçolli,Paola Jung
Brianezi,Gabrielli
Schmitt,Juliano Vilaverde
Marques,Mariângela Esther Alencar
Miot,Hélio Amante
author_role author
author2 Brianezi,Gabrielli
Schmitt,Juliano Vilaverde
Marques,Mariângela Esther Alencar
Miot,Hélio Amante
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mendaçolli,Paola Jung
Brianezi,Gabrielli
Schmitt,Juliano Vilaverde
Marques,Mariângela Esther Alencar
Miot,Hélio Amante
dc.subject.por.fl_str_mv Carcinoma, basal cell
Chromatin
Karyometry
Image processing, computer-assisted
Prognosis
topic Carcinoma, basal cell
Chromatin
Karyometry
Image processing, computer-assisted
Prognosis
description Abstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20154076
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.90 n.6 2015
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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