Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874 |
Resumo: | Abstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype. |
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Anais brasileiros de dermatologia (Online) |
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Nuclear morphometry and chromatin textural characteristics of basal cell carcinomaCarcinoma, basal cellChromatinKaryometryImage processing, computer-assistedPrognosisAbstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype.Sociedade Brasileira de Dermatologia2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874Anais Brasileiros de Dermatologia v.90 n.6 2015reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20154076info:eu-repo/semantics/openAccessMendaçolli,Paola JungBrianezi,GabrielliSchmitt,Juliano VilaverdeMarques,Mariângela Esther AlencarMiot,Hélio Amanteeng2015-12-22T00:00:00Zoai:scielo:S0365-05962015000600874Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2015-12-22T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
title |
Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
spellingShingle |
Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma Mendaçolli,Paola Jung Carcinoma, basal cell Chromatin Karyometry Image processing, computer-assisted Prognosis |
title_short |
Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
title_full |
Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
title_fullStr |
Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
title_full_unstemmed |
Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
title_sort |
Nuclear morphometry and chromatin textural characteristics of basal cell carcinoma |
author |
Mendaçolli,Paola Jung |
author_facet |
Mendaçolli,Paola Jung Brianezi,Gabrielli Schmitt,Juliano Vilaverde Marques,Mariângela Esther Alencar Miot,Hélio Amante |
author_role |
author |
author2 |
Brianezi,Gabrielli Schmitt,Juliano Vilaverde Marques,Mariângela Esther Alencar Miot,Hélio Amante |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Mendaçolli,Paola Jung Brianezi,Gabrielli Schmitt,Juliano Vilaverde Marques,Mariângela Esther Alencar Miot,Hélio Amante |
dc.subject.por.fl_str_mv |
Carcinoma, basal cell Chromatin Karyometry Image processing, computer-assisted Prognosis |
topic |
Carcinoma, basal cell Chromatin Karyometry Image processing, computer-assisted Prognosis |
description |
Abstract: Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962015000600874 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/abd1806-4841.20154076 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.90 n.6 2015 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126420613595136 |