Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,

Detalhes bibliográficos
Autor(a) principal: Leite,Oriete Gerin
Data de Publicação: 2020
Outros Autores: Tagliolatto,Sandra, Souza,Elemir Macedo de, Cintra,Maria Letícia
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000100063
Resumo: Abstract Topical use of immune response modifiers, such as imiquimod, has increased in dermatology. Although its topical use is well tolerated, it may be associated with exacerbations of generalized cutaneous inflammatory diseases, possibly through the systemic circulation of pro-inflammatory cytokines. This report describes a case of development of pityriasis rubra pilaris, a rare erythematous-papulosquamous dermatosis, in a woman aged 60 years during treatment with imiquimod 5% cream for actinic keratosis. It evolved with erythrodermic conditions and palmoplantar keratoderma, presenting progressive clinical resolution after the introduction of methotrexate. The authors emphasize the importance of recognizing possible systemic reactions associated with the topical use of imiquimod.
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spelling Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,AminoquinolinesDrug eruptionsKeratosis, actinicMethotrexatePityriasis rubra pilarisAbstract Topical use of immune response modifiers, such as imiquimod, has increased in dermatology. Although its topical use is well tolerated, it may be associated with exacerbations of generalized cutaneous inflammatory diseases, possibly through the systemic circulation of pro-inflammatory cytokines. This report describes a case of development of pityriasis rubra pilaris, a rare erythematous-papulosquamous dermatosis, in a woman aged 60 years during treatment with imiquimod 5% cream for actinic keratosis. It evolved with erythrodermic conditions and palmoplantar keratoderma, presenting progressive clinical resolution after the introduction of methotrexate. The authors emphasize the importance of recognizing possible systemic reactions associated with the topical use of imiquimod.Sociedade Brasileira de Dermatologia2020-02-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000100063Anais Brasileiros de Dermatologia v.95 n.1 2020reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1016/j.abd.2019.01.009info:eu-repo/semantics/openAccessLeite,Oriete GerinTagliolatto,SandraSouza,Elemir Macedo deCintra,Maria Letíciaeng2020-03-26T00:00:00Zoai:scielo:S0365-05962020000100063Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2020-03-26T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,
title Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,
spellingShingle Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,
Leite,Oriete Gerin
Aminoquinolines
Drug eruptions
Keratosis, actinic
Methotrexate
Pityriasis rubra pilaris
title_short Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,
title_full Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,
title_fullStr Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,
title_full_unstemmed Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,
title_sort Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review,
author Leite,Oriete Gerin
author_facet Leite,Oriete Gerin
Tagliolatto,Sandra
Souza,Elemir Macedo de
Cintra,Maria Letícia
author_role author
author2 Tagliolatto,Sandra
Souza,Elemir Macedo de
Cintra,Maria Letícia
author2_role author
author
author
dc.contributor.author.fl_str_mv Leite,Oriete Gerin
Tagliolatto,Sandra
Souza,Elemir Macedo de
Cintra,Maria Letícia
dc.subject.por.fl_str_mv Aminoquinolines
Drug eruptions
Keratosis, actinic
Methotrexate
Pityriasis rubra pilaris
topic Aminoquinolines
Drug eruptions
Keratosis, actinic
Methotrexate
Pityriasis rubra pilaris
description Abstract Topical use of immune response modifiers, such as imiquimod, has increased in dermatology. Although its topical use is well tolerated, it may be associated with exacerbations of generalized cutaneous inflammatory diseases, possibly through the systemic circulation of pro-inflammatory cytokines. This report describes a case of development of pityriasis rubra pilaris, a rare erythematous-papulosquamous dermatosis, in a woman aged 60 years during treatment with imiquimod 5% cream for actinic keratosis. It evolved with erythrodermic conditions and palmoplantar keratoderma, presenting progressive clinical resolution after the introduction of methotrexate. The authors emphasize the importance of recognizing possible systemic reactions associated with the topical use of imiquimod.
publishDate 2020
dc.date.none.fl_str_mv 2020-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000100063
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000100063
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.abd.2019.01.009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.95 n.1 2020
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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