Spitz nevus and infliximab: association or coincidence?,

Detalhes bibliográficos
Autor(a) principal: Queirós,Catarina Soares
Data de Publicação: 2020
Outros Autores: Laureano-Oliveira,André, Lopéz-Presa,Dolores, Filipe,Paulo
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000500615
Resumo: Abstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this paper, we describe the case of a 28-year-old woman who developed a spitzoid melanocytic tumor after starting infliximab therapy for ulcerative colitis. The evidence for causality between anti-TNF and melanocytic proliferations is still sparse; nonetheless, treatment-associated immunosuppression seems to play a key role in this phenomenon. Therefore, a regular follow-up with a rigorous skin examination is essential in these patients. Noninvasive techniques such as dermoscopy or reflectance confocal microscopy are particularly useful diagnostic tools in these circumstances.
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spelling Spitz nevus and infliximab: association or coincidence?,Biological agentsConfocal microscopyDermoscopyNevus, epithelioid and spindle cellSkin neoplasmsAbstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this paper, we describe the case of a 28-year-old woman who developed a spitzoid melanocytic tumor after starting infliximab therapy for ulcerative colitis. The evidence for causality between anti-TNF and melanocytic proliferations is still sparse; nonetheless, treatment-associated immunosuppression seems to play a key role in this phenomenon. Therefore, a regular follow-up with a rigorous skin examination is essential in these patients. Noninvasive techniques such as dermoscopy or reflectance confocal microscopy are particularly useful diagnostic tools in these circumstances.Sociedade Brasileira de Dermatologia2020-10-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000500615Anais Brasileiros de Dermatologia v.95 n.5 2020reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1016/j.abd.2020.01.008info:eu-repo/semantics/openAccessQueirós,Catarina SoaresLaureano-Oliveira,AndréLopéz-Presa,DoloresFilipe,Pauloeng2020-11-12T00:00:00Zoai:scielo:S0365-05962020000500615Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2020-11-12T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Spitz nevus and infliximab: association or coincidence?,
title Spitz nevus and infliximab: association or coincidence?,
spellingShingle Spitz nevus and infliximab: association or coincidence?,
Queirós,Catarina Soares
Biological agents
Confocal microscopy
Dermoscopy
Nevus, epithelioid and spindle cell
Skin neoplasms
title_short Spitz nevus and infliximab: association or coincidence?,
title_full Spitz nevus and infliximab: association or coincidence?,
title_fullStr Spitz nevus and infliximab: association or coincidence?,
title_full_unstemmed Spitz nevus and infliximab: association or coincidence?,
title_sort Spitz nevus and infliximab: association or coincidence?,
author Queirós,Catarina Soares
author_facet Queirós,Catarina Soares
Laureano-Oliveira,André
Lopéz-Presa,Dolores
Filipe,Paulo
author_role author
author2 Laureano-Oliveira,André
Lopéz-Presa,Dolores
Filipe,Paulo
author2_role author
author
author
dc.contributor.author.fl_str_mv Queirós,Catarina Soares
Laureano-Oliveira,André
Lopéz-Presa,Dolores
Filipe,Paulo
dc.subject.por.fl_str_mv Biological agents
Confocal microscopy
Dermoscopy
Nevus, epithelioid and spindle cell
Skin neoplasms
topic Biological agents
Confocal microscopy
Dermoscopy
Nevus, epithelioid and spindle cell
Skin neoplasms
description Abstract Biological therapies, including anti-TNF agents, are important in the treatment of various chronic inflammatory diseases, including psoriasis, rheumatoid arthritis or inflammatory bowel disease. The increased use of these drugs translates into an increasing awareness of its adverse effects, which include malignancy. In this paper, we describe the case of a 28-year-old woman who developed a spitzoid melanocytic tumor after starting infliximab therapy for ulcerative colitis. The evidence for causality between anti-TNF and melanocytic proliferations is still sparse; nonetheless, treatment-associated immunosuppression seems to play a key role in this phenomenon. Therefore, a regular follow-up with a rigorous skin examination is essential in these patients. Noninvasive techniques such as dermoscopy or reflectance confocal microscopy are particularly useful diagnostic tools in these circumstances.
publishDate 2020
dc.date.none.fl_str_mv 2020-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000500615
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962020000500615
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.abd.2020.01.008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.95 n.5 2020
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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