Leprosy: clinical and immunopathological characteristics

Detalhes bibliográficos
Autor(a) principal: Froes Junior,Luis Alberto Ribeiro
Data de Publicação: 2022
Outros Autores: Sotto,Mirian Nacagami, Trindade,Maria Angela Bianconcini
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000300338
Resumo: Abstract Leprosy, a disease caused by Mycobacterium leprae, has polymorphic neurocutaneous manifestations strongly correlated with the host immune response. Peripheral neural damage can lead to sensory and motor losses, as well as deformities of the hands and feet. Both innate and acquired immune responses are involved, but the disease has been classically described along a Th1/Th2 spectrum, where the Th1 pole corresponds to the more limited presentations and the Th2 to the multibacillary ones. The aim of this review is to discuss this dichotomy in light of the current knowledge of the cytokines, T helper subpopulations, and regulatory T cells involved in each presentation of leprosy. The text will also address leprosy reactions related to increased inflammatory activity in both limited and multibacillary presentations, leading to exacerbation of chronic signs and symptoms and/or the development of new ones. Despite the efforts of many research groups around the world, there is no standardized serological test/biological marker for diagnosis so far, even in endemic areas, which could contribute to the eradication of leprosy.
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spelling Leprosy: clinical and immunopathological characteristicsImmunologyLeprosyLymphocyte activationMycobacterium lepraeAbstract Leprosy, a disease caused by Mycobacterium leprae, has polymorphic neurocutaneous manifestations strongly correlated with the host immune response. Peripheral neural damage can lead to sensory and motor losses, as well as deformities of the hands and feet. Both innate and acquired immune responses are involved, but the disease has been classically described along a Th1/Th2 spectrum, where the Th1 pole corresponds to the more limited presentations and the Th2 to the multibacillary ones. The aim of this review is to discuss this dichotomy in light of the current knowledge of the cytokines, T helper subpopulations, and regulatory T cells involved in each presentation of leprosy. The text will also address leprosy reactions related to increased inflammatory activity in both limited and multibacillary presentations, leading to exacerbation of chronic signs and symptoms and/or the development of new ones. Despite the efforts of many research groups around the world, there is no standardized serological test/biological marker for diagnosis so far, even in endemic areas, which could contribute to the eradication of leprosy.Sociedade Brasileira de Dermatologia2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000300338Anais Brasileiros de Dermatologia v.97 n.3 2022reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1016/j.abd.2021.08.006info:eu-repo/semantics/openAccessFroes Junior,Luis Alberto RibeiroSotto,Mirian NacagamiTrindade,Maria Angela Bianconcinieng2022-06-10T00:00:00Zoai:scielo:S0365-05962022000300338Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2022-06-10T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Leprosy: clinical and immunopathological characteristics
title Leprosy: clinical and immunopathological characteristics
spellingShingle Leprosy: clinical and immunopathological characteristics
Froes Junior,Luis Alberto Ribeiro
Immunology
Leprosy
Lymphocyte activation
Mycobacterium leprae
title_short Leprosy: clinical and immunopathological characteristics
title_full Leprosy: clinical and immunopathological characteristics
title_fullStr Leprosy: clinical and immunopathological characteristics
title_full_unstemmed Leprosy: clinical and immunopathological characteristics
title_sort Leprosy: clinical and immunopathological characteristics
author Froes Junior,Luis Alberto Ribeiro
author_facet Froes Junior,Luis Alberto Ribeiro
Sotto,Mirian Nacagami
Trindade,Maria Angela Bianconcini
author_role author
author2 Sotto,Mirian Nacagami
Trindade,Maria Angela Bianconcini
author2_role author
author
dc.contributor.author.fl_str_mv Froes Junior,Luis Alberto Ribeiro
Sotto,Mirian Nacagami
Trindade,Maria Angela Bianconcini
dc.subject.por.fl_str_mv Immunology
Leprosy
Lymphocyte activation
Mycobacterium leprae
topic Immunology
Leprosy
Lymphocyte activation
Mycobacterium leprae
description Abstract Leprosy, a disease caused by Mycobacterium leprae, has polymorphic neurocutaneous manifestations strongly correlated with the host immune response. Peripheral neural damage can lead to sensory and motor losses, as well as deformities of the hands and feet. Both innate and acquired immune responses are involved, but the disease has been classically described along a Th1/Th2 spectrum, where the Th1 pole corresponds to the more limited presentations and the Th2 to the multibacillary ones. The aim of this review is to discuss this dichotomy in light of the current knowledge of the cytokines, T helper subpopulations, and regulatory T cells involved in each presentation of leprosy. The text will also address leprosy reactions related to increased inflammatory activity in both limited and multibacillary presentations, leading to exacerbation of chronic signs and symptoms and/or the development of new ones. Despite the efforts of many research groups around the world, there is no standardized serological test/biological marker for diagnosis so far, even in endemic areas, which could contribute to the eradication of leprosy.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000300338
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000300338
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.abd.2021.08.006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.97 n.3 2022
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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