Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection

Detalhes bibliográficos
Autor(a) principal: Marques,Thamirys Guimarães
Data de Publicação: 2012
Outros Autores: Chaib,Eleazar, Fonseca,Juliana Hamati da, Lourenço,Ana Cecília Rodrigues, Silva,Felipe Duarte, Ribeiro Jr,Marcelo Augusto Fontenelle, Galvão,Flavio Henrique Ferreira, D'Albuquerque,Luiz Augusto Carneiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000800013
Resumo: PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.
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spelling Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injectionLiver CirrhosisDrugsCarbon TetrachlorideCommon Bile DuctRatosPURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000800013Acta Cirúrgica Brasileira v.27 n.8 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012000800013info:eu-repo/semantics/openAccessMarques,Thamirys GuimarãesChaib,EleazarFonseca,Juliana Hamati daLourenço,Ana Cecília RodriguesSilva,Felipe DuarteRibeiro Jr,Marcelo Augusto FontenelleGalvão,Flavio Henrique FerreiraD'Albuquerque,Luiz Augusto Carneiroeng2012-07-25T00:00:00Zoai:scielo:S0102-86502012000800013Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-07-25T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
title Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
spellingShingle Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
Marques,Thamirys Guimarães
Liver Cirrhosis
Drugs
Carbon Tetrachloride
Common Bile Duct
Ratos
title_short Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
title_full Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
title_fullStr Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
title_full_unstemmed Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
title_sort Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
author Marques,Thamirys Guimarães
author_facet Marques,Thamirys Guimarães
Chaib,Eleazar
Fonseca,Juliana Hamati da
Lourenço,Ana Cecília Rodrigues
Silva,Felipe Duarte
Ribeiro Jr,Marcelo Augusto Fontenelle
Galvão,Flavio Henrique Ferreira
D'Albuquerque,Luiz Augusto Carneiro
author_role author
author2 Chaib,Eleazar
Fonseca,Juliana Hamati da
Lourenço,Ana Cecília Rodrigues
Silva,Felipe Duarte
Ribeiro Jr,Marcelo Augusto Fontenelle
Galvão,Flavio Henrique Ferreira
D'Albuquerque,Luiz Augusto Carneiro
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Marques,Thamirys Guimarães
Chaib,Eleazar
Fonseca,Juliana Hamati da
Lourenço,Ana Cecília Rodrigues
Silva,Felipe Duarte
Ribeiro Jr,Marcelo Augusto Fontenelle
Galvão,Flavio Henrique Ferreira
D'Albuquerque,Luiz Augusto Carneiro
dc.subject.por.fl_str_mv Liver Cirrhosis
Drugs
Carbon Tetrachloride
Common Bile Duct
Ratos
topic Liver Cirrhosis
Drugs
Carbon Tetrachloride
Common Bile Duct
Ratos
description PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.
publishDate 2012
dc.date.none.fl_str_mv 2012-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000800013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000800013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502012000800013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.27 n.8 2012
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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